The pharmaceutical pollutant fluoxetine alters reproductive behaviour in a fish independent of predation risk

Fursdon, Jack B.; Martin, Jake M.; Bertram, Michael G.; Lehtonen, Topi K.; Wong, Bob B. M.

doi:10.1016/j.scitotenv.2018.09.046

Cited by 54 publications

(45 citation statements)

References 118 publications

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“…For all three treatments, fish were held in flow-through systems (24 h cycling), with eight tanks per treatment (24 tanks total; housing approximately 20 fish per tank) over the 28 days. Exposure was performed following previously established protocols (see electronic supplementary material, S1.1; [33][34][35][36]). During the exposure, gas chromatography coupled to tandem mass spectrometry was used for analytical verification of fluoxetine concentrations (described in [36]).…”

Section: Methodsmentioning

confidence: 99%

“…video identification tags did not contain experimental treatment information) using open-source event-logging software (BORIS v. 7.4.7; [38]). Specifically, for each fish, the time taken to first consume a prey item, and Fursdon et al [35]). Following behavioural trials, all fish were measured for weight (±0.0001 g) and standard length (±0.01 mm).…”

Section: Methodsmentioning

confidence: 99%

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Field-realistic antidepressant exposure disrupts group foraging dynamics in mosquitofish

et al. 2019

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Psychoactive pollutants, such as antidepressants, are increasingly detected in the environment. Mounting evidence suggests that such pollutants can disrupt the behaviour of non-target species. Despite this, few studies have considered how the response of exposed organisms might be mediated by social context. To redress this, we investigated the impacts of two environmentally realistic concentrations of a pervasive antidepressant pollutant, fluoxetine, on foraging behaviour in fish ( Gambusia holbrooki ), tested individually or in a group. Fluoxetine did not alter behaviour of solitary fish. However, in a group setting, fluoxetine exposure disrupted the frequency of aggressive interactions and food consumption, with observed effects being contingent on both the mean weight of group members and the level of within-group variation in weight. Our results suggest that behavioural tests in social isolation may not accurately predict the environmental risk of chemical pollutants for group-living species and highlight the potential for social context to mediate the effects of psychoactive pollutants in exposed wildlife.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Field-realistic antidepressant exposure disrupts group foraging dynamics in mosquitofish

et al. 2019

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“…Moreover, knowing that the anatomical organization of brain serotonergic systems is remarkably conserved among vertebrates [60], implying that the functions of the 5-HT neurotransmitter may also have been conserved as revealed in recent studies with teleosts [61][62][63], the fish, Deuterodon iguape, was chosen as a biological model, and it is an endemic species of small rivers and coastal streams of the state of São Paulo [64,65]. Apparently, the neurotransmitter 5-HT also plays an important role in aquatic invertebrates, such as crustaceans, mediating many physiological and behavioral processes [66].…”

Section: Discussionmentioning

confidence: 99%

Effect of Fluoxetine Hydrochloride on Routine Metabolism of Lambari (Deuterodon iguape, Eigenmann, 1907) and Phantom Shrimp (Palaemon pandaliformis, Stimpson, 1871)

Rezende¹,

Almeida

Henriques

et al. 2021

Braz. arch. biol. technol.

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Fluoxetine is an emerging pollutant that acts as a selective serotonin reuptake inhibitor (SSRI) and being a hydrolytic molecule that is photolytically stable and accumulaties in biological tissues, its disposal in the aquatic environment can interfere with the physiology of fish and shrimp. Thus, the objective of this study was to analyze the effects of fluoxetine on routine metabolism (metabolic rate, specific ammonia excretion and O:N ratio) of Deuterodon iguape and Palaemon pandaliformis. For this, five groups of each species, were exposed to different concentrations of fluoxetine for 24 hours (D. iguape) and 2 hours (P. pandaliformis). The results demonstrated that in D. iguape exposure to fluoxetine significantly increased both the metabolic rate by 75%, 85%, 55% and 50% for concentrations of 0.05; 0.1; 0.5 and 1.0 mgL -1 , respectively, and the specific ammonia excretion by 40%, 48% and 20% for concentrations of 0.05; 0.1 and 0.5 mgL -1 , respectively, when compared with their control. The O:N ratio was statistically greater in concentrations of 0.5 and 1.0 mgL -1 . Concerning P. pandaliformis, exposure to fluoxetine increased metabolic rate at concentrations 30.0 and HIGHLIGHTS  Fluoxetine increases the metabolic rate and excretion of ammonia in both species. O:N ratio in fish showed higher values in the highest concentrations of fluoxetine.  The LC50 -96 hour values of Palaemon pandaliformis represented greater toxicity.  Both species are a good biological model for fluoxetine exposure studies. Rezende, K.F.O.; et al.

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“…The potential effects of pharmaceutical pollution may include the promotion of multidrug resistant bacterial strains and/or deleterious acute or chronic ecotoxicological impacts on non-target organisms (Brodin et al, 2013;Hernando-Amado et al, 2019;Kumar et al, 2019). For example, fluoxetine has been shown to cause reproductive delay in leopard frogs (Foster et al, 2010;Fursdon et al, 2019;Hellström et al, 2016), while ciprofloxacin can cause genotoxic effects in plankton and algae (Carusso et al, 2018) (Dionísio et al, 2020). Further, certain pharmaceuticals are also endocrine disrupting chemicals (EDCs), and have been shown to exert significant reproductive effects even at trace environmental levels.…”

Section: Introductionmentioning

confidence: 99%

A SPE-HPLC-MS/MS method for the simultaneous determination of prioritised pharmaceuticals and EDCs with high environmental risk potential in freshwater

Taggart

McKenzie³

et al. 2021

Journal of Environmental Sciences

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This work describes the development, optimisation and validation of an analytical method for the rapid determination of 17 priority pharmaceutical compounds and endocrine disrupting chemicals (EDCs). Rather than studying compounds from the same therapeutic class, the analyses aimed to determine target compounds with the highest risk potential with regard to Scotland, providing a tool for further monitoring in different water matrices. Prioritisation was based on a systematic environmental risk assessment approach, using consumption data; wastewater treatment removal efficiency; environmental occurrence; toxicological effects; and pre-existing regulatory indicators. This process highlighted 17 compounds across various therapeutic classes, which were then quantified, at environmentally relevant concentrations, by a single analytical methodology. Analytical determination was achieved using a single-step solid phase extraction (SPE) procedure followed by high-performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS). The fully optimised method performed well for the majority of target compounds, with recoveries >71% for 15 of 17 analytes. The limits of quantification for most target analytes (14 of 17) ranged from 0.07 ng•L -1 to 1.88 ng•L -1 in river waters. The utility of this method was then demonstrated using real water samples associated with a rural hospital/setting. Eight compounds were targeted and detected, with the highest levels found for the analgesic, paracetamol (at up to 105910 ng•L -1 in the hospital discharge). This method offers a robust tool to monitor high priority pharmaceutical and EDC levels in various aqueous sample matrices.

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The pharmaceutical pollutant fluoxetine alters reproductive behaviour in a fish independent of predation risk

Cited by 54 publications

References 118 publications

Field-realistic antidepressant exposure disrupts group foraging dynamics in mosquitofish

Field-realistic antidepressant exposure disrupts group foraging dynamics in mosquitofish

Effect of Fluoxetine Hydrochloride on Routine Metabolism of Lambari (Deuterodon iguape, Eigenmann, 1907) and Phantom Shrimp (Palaemon pandaliformis, Stimpson, 1871)

A SPE-HPLC-MS/MS method for the simultaneous determination of prioritised pharmaceuticals and EDCs with high environmental risk potential in freshwater

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