The Pharmaceutical and Cosmetic Industries

Goossens, An; Geebelen, Julie; Hulst, Kim Vander; Gilissen, Liesbeth

doi:10.1007/978-3-319-40221-5_180-2

Cited by 1 publication

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“…Health‐care workers (HCWs), but also workers in the pharmaceutical industry, who may also react to drug intermediates, are at risk . The lesions most commonly occur at the site of contact, which is generally the hands; however, airborne reactions from powdered drugs, droplets, or vapors are not uncommon, and even generalized reactions may develop due to inhalation or transcutaneous absorption …”

Section: Introductionmentioning

confidence: 99%

Occupational allergic contact dermatitis from systemic drugs

et al. 2019

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Background: Health-care workers (HCWs) and professionals working in the pharmaceutical industry are at risk of developing occupational allergic contact dermatitis (OACD) from systemic drugs (or drug intermediates).Objectives: To study demographic characteristics and identify systemic drugs responsible for OACD in patients investigated for contact allergy during the period 2001-2019.Methods: In the study period, 9780 patients were patch tested with the European baseline series, sometimes with additional series, and other relevant potential allergens. All patients with a positive patch-test reaction to systemic medication exposed to at work were included for further analysis.Results: Of 1248 HCWs examined in our clinic, 201 suffered from OACD. In 26 (13%) dermatitis was caused by skin contact with a systemic drug: 19 nurses, five chemists working in the pharmaceutical industry, one physician, and one veterinarian. In total, 45 positive patch-test reactions to 20 different systemic drugs were found, with tetrazepam (n = 11), ranitidine hydrochloride (n = 5), and zolpidem (n = 4) being the most frequent. Three pharmaceutical chemists were sensitized to a drug intermediate. The lesions were mostly localized on the hands, but often also on the face, as airborne dermatitis.

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Section: Introductionmentioning

confidence: 99%