The Phagocytosis of Leucocytes

Senda, N.

doi:10.1620/tjem.76.119

Cited by 10 publications

(4 citation statements)

References 2 publications

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“…On the other hand, intcraction with the PMN membrane might be expected to alter its supcrficial molecular conformation such that the altered electrostatic characteristics would not favour pseudopod formation (Weiss & Woodbridge, 1967). Concomitantly the rise in local surface tension would rendcr the membrane less dcformable (Senda, 1962). Such membrane effects would also account for the lowered adhesiveness formerly described and for the poor emigration here reported in paraproteinaemias.…”

Section: Discussionmentioning

confidence: 61%

Inflammation and Haemostasis in Paraproteinaemias

1971

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Summary. Inflammatory and haemostatic functions were assessed simultaneously in 16 patients with serum paraproteins. Skin window responses were severely depressed in 10; neutrophil phagocytosis was reduced in five. Platelet function was abnormal in 10 and inhibitors of blood coagulation were found in four. Whereas the changes in platelet function appeared to be more concentration‐dependent, abnormal skin window responses occurred at all concentrations of paraprotein. The effect on coagulation and neutrophil phagocytosis appears to be specific for a given paraprotein. Study of isolated γG paraproteins showed this depression of cell function to be markedly concentration‐dependent. Haemostatic defects were corrected by plasmapheresis. Clinical infection and bleeding were prevalent only in patients with levels of paraprotein in excess of 5 g/100 ml, despite abnormal test results at lower concentrations.

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Section: Discussionmentioning

confidence: 61%

Inflammation and Haemostasis in Paraproteinaemias

1971

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“…aiid Rossi and Zatti (1964). Thc morphological aspects of phagocytosis as sccii with light and electron microscopy have been reportcd by Senda (1962), Zucker-Franklin and Hirsch (r964), aiid by Zatti et A[. (1965).…”

Section: Discussionmentioning

confidence: 91%

Studies on Neutrophil Function I. Physiological and Pharmacological Aspects

et al. 1966

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During inflammation, the circulating neutrophil adheres to the altered venular endothelium (Marchesi, 1964; Cotran, 1965), and emigrates between the endothelial cells into the tissue towards its prey. Both phenomena were first observed by Dutrochet in 1824 in the small blood vessels of the tail of the frog tadpole. Accurate observations on the margination and emigration of leucocytes in inflammation were made between 1833 and 1850 by Wagner, Waller, Addison and Wharton–Jones, and later by Cohnheim and Adami. The history of the early work is reviewed by Grant (1965). The amoeboid locomotion of leucocytes was studied by Metchnikoff at the end of the 19th century. He introduced the term phagocytosis and was the first to recognize it as a defence reaction (1893), his contemporaries including Klebs, Koch, Waldeyer and Virchow having regarded leucocytes as a source of dissemination of the bacteria they had observed within them. Pseudopodia form and enclose the particles to be phagocytosed within a phagocytic vacuole into which are discharged the enzyme‐rich contents of the neutrophil granules (Senda, 1962; Zucker‐Franklin and Hirsch, 1964; Zatti, Rossi and Meneghell, 1965). This process requires the participation of intrinsic neutrophil mechanisms and of extrinsic serum and tissue components. The biochemical aspects of neutrophil function at rest and in action have been investigated, (Karnovsky, 1962; Rossi and Zatti, 1964; Ohta, 1964a, b; Perry, 1964; Zatti et al., 1965) but recently more attention has been directed towards the extracellular components concerned in leucocyte emigration (Hurley, 1964), adhesiveness (Rabinowitz, 1964), chemotaxis (Boyden, North and Faulkner, 1965; Ward, Cochrane and Müller‐Eberhard, 1965), phagocytosis (Tullis and Surgenor, 1950; Nelson and Lebrun, 1956; Boyden, 1963; Gerlings‐Petersen and Pondman, 1964; Vaughan, 1965), and the post‐phagocytic phase (Li, Mudd and Kapral, 1963; Archer, 1964; Boyden et al., 1965). In the present study, adhesiveness and phagocytosis were the two aspects of neutrophil function assessed in vitro under physiological and pharmacological conditions (I) and in pathological states (II), in the hope of casting light on the causes of disturbed function in a variety of pathological states.

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“…The ATP increases even in low concentration the permeability of blood vessels, the perivascular infiltration (1), the motility and phago cytic ability of leucocytes (9). It is possible that the increased ATP concentration in the inflamed tissue is significant not only from the point of view of the energetic condition, but the ATP parti cipates directly also in the development of inflammatory response.…”

Section: Discussionmentioning

confidence: 99%