The phagocytic receptors of β-glucan

Zhang, Yazhou; Liu, Xinning; Zhao, Jun; Wang, Jie; Song, Qiaoling; Zhao, Chenyang

doi:10.1016/j.ijbiomac.2022.02.111

Cited by 27 publications

(23 citation statements)

References 130 publications

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“…However, Wang et al have not found any Fuc and α-glucans in M. albuminosa PSs [ 82 ], which should be accepted as a structural difference between the PSs of both species. For many immunomodulating mushroom β -glucans, most of the molecular mechanisms of immunomodulation are clear, along with the anticancer action, while different cell surface receptors have been identified [ 84 ]. Unlike β -glucans, immune-related receptors for immunomodulating fucogalactan recognition are still unclear, which, from a biochemical point of view, should be elucidated in the near future.…”

Section: Discussionmentioning

confidence: 99%

Structural Features and Immunomodulatory Effects of Water-Extractable Polysaccharides from Macrolepiota procera (Scop.) Singer

Georgiev

Vašíček

Dzhambazov

et al. 2022

JoF

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Macrolepiota procera (MP) is an edible mushroom used in the treatment of diabetes, hypertension and inflammation. However, the structure and biological effects of its polysaccharides (PSs) are unclear. This study investigates the structural features of a PS complex from MP (MP-PSC), its immunomodulatory activities and effects on probiotic and pathogenic bacteria. MP-PSC was obtained by boiling water, and PSs were characterized by 2D NMR spectroscopy. The immunomodulatory effects on blood and derived neutrophils, other leukocytes, and murine macrophages were studied by flow cytometry, chemiluminescence, spectrophotometry, and ELISA. The total carbohydrate content of MP-PSC was 74.2%, with glycogen occupying 36.7%, followed by β-D-glucan, α-L-fuco-2-(1,6)-D-galactan, and β-D-glucomannan. MP-PSC (200 μg/mL) increased the number of CD14+ monocyte cells in the blood, after ex vivo incubation for 24 h. It dose-dependently (50–200 μg/mL) activated the spontaneous oxidative burst of whole blood phagocytes, NO, and interleukin 6 productions in RAW264.7 cells. MP-PSC exhibited a low antioxidant activity and failed to suppress the oxidative burst and NO generation, induced by inflammatory agents. It (2.0%, w/v) stimulated probiotic co-cultures and hindered the growth and biofilm development of Escherichia coli, Streptococcus mutans and Salmonella enterica. MP PSs can be included in synbiotics to test their immunostimulating effects on compromised immune systems and gut health.

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Section: Discussionmentioning

confidence: 99%

Structural Features and Immunomodulatory Effects of Water-Extractable Polysaccharides from Macrolepiota procera (Scop.) Singer

Georgiev

Vašíček

Dzhambazov

et al. 2022

JoF

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“…β-glucans are abundant polysaccharides found in nature; when they are bound to specific receptors in the immune system, they initiate phagocytosis. Phagocytosis is responsible for regulating inflammation and immune responses in the body, maintaining tissue homeostasis (Zhang et al, 2022). When β-glucan is ingested in the human body, they are most likely to show resistance to stomach acid and then they gradually pass through the first part of the small intestine.…”

Section: Effects Of β-Glucan On Human Immune Systemmentioning

confidence: 99%

“…The PRRs like Toll-like immunoreceptors and Dectin-1 are present on the surface of phagocytes, including macrophages, cytokines, heterophils, and dendritic cells, they activate the immune system. Dectin-1 is the most commonly used receptor by β-glucans (Zhang et al, 2022). It is the most abundant receptor on dendritic cells, monocytes, and macrophages, providing efficient binding with the abundant β-glucans (Chodakowska et al, 2021).…”

Section: Effects Of β-Glucan On Human Immune Systemmentioning

confidence: 99%

“…For example, curdlan (1-3) with higher molecular weight can directly activate leukocytes to phagocytosis and produce inflammatory mediators and cytokines. On the other hand, low molecular weighted soluble yeast sourced β-glucan can cause antagonistic activities against macrophage production of reactive oxygens and cytokine synthesis by binding with Dectin-1 (Han et al, 2020;Zhang et al, 2022). Therefore, the specific physicochemical properties of the β-glucan can affect its role and efficiency in the immune system.…”

Section: Effects Of β-Glucan On Human Immune Systemmentioning

confidence: 99%

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Beta-Glucan as a Novel Functional Fiber: Functional Properties, Health Benefits and Food Applications

Sinangil

Taştan

Baysal

2022

Turkish JAF Sci.Tech.

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Recently the demand for functional food components such as prebiotics, probiotics, and phenolic compounds are increased. Nowadays, β-glucan, dietary fiber, and biologically active natural polysaccharide, exhibit properties like a prebiotic effect and immune system support. Furthermore, clinical studies have shown that daily intake of 250-500 mg β-glucan has several benefits on the immune system, showing low glycemic index, antimicrobial and anti-inflammatory properties. It is a polysaccharide composed of D-glucose monomers connected with β-glycoside bonds, found in natural sources like yeast (Saccharomyces cerevisiae), some edible mushrooms, algae, and cereal grains. β-Glucan is more resistant and preserves its stability during food processing technologies (drying, freezing, etc.). Especially, β-glucan originated from baker's yeast (S. cerevisiae) has many immunostimulatory properties, such as hypoglycemic, anti-inflammatory, immune-modulatory, antioxidant, and anticancer activities. Also, the utilization of β-glucan in the food industry has increased regarding to their techno-functional properties like gelation, viscosity, solubility, and encapsulating agent. Therefore, this review highlights recently published research results on the functional properties, health benefits and clinical studies, the effects on the interaction with the other food compounds, and the potential food applications of β-glucans.

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“…β-glucans are well known as a food supplement, which supports immune system and antioxidant activity, and improves digestion thanks to prebiotic activity. The immune response happens when β-glucan attaches to specific receptors of an immune cell and induces phagocytosis, a biological mechanism that keeps tissue equilibrium [ 21 ]. This effect happens directly.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Biochemical and Genetic Variability of Pleurotus ostreatus Based on the β-Glucans and CDDP Markers

Golian

Chlebová

Žiarovská

et al. 2022

JoF

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Oyster mushroom (Pleurotus ostreatus) is still one of the most cultivated edible and medicinal mushrooms. Despite its frequent cultivation around the world, there is currently just a little information available on the variability of strains in terms of the content of β-glucans in them. This work presents an extensive study of 60 strains in terms of the content of α-glucans and β-glucans in their caps and stipes. The authenticity of the production strains based on an analysis of the variability of their genome by CDDP (Conserved DNA-derived polymorphism) markers was confirmed, whereas identical CDDP profiles were identified between samples 45, 89, 95, and 96. Genetic variability of the analyzed production strains showed a high polymorphism and effective discriminative power of the used marking technique. Medium positive correlations were found among the CDDP profiles and β-glucan content in the group of strains that generated the same CDDP profiles, and low negative correlation was found among these profiles in the group of low β-glucan content strains. For the determination of glucans content, Mushroom and Yeast analytical enzymatic kit (Megazyme, Bray, Co. Wicklow, Ireland) were used. The results clearly showed that the stipe contains on average 33% more β-glucans than the cap. The minimum detected β-glucan content in the stipe was in strain no. 72, specifically 22%, and the maximum in strain no. 43, specifically 56%, which after the conversion represents a difference of 155%. From the point of view of β-glucan content, the stated strain no. 43 appears to be very suitable for the commercial production of β-glucans under certain conditions.

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The phagocytic receptors of β-glucan

Cited by 27 publications

References 130 publications

Structural Features and Immunomodulatory Effects of Water-Extractable Polysaccharides from Macrolepiota procera (Scop.) Singer

Structural Features and Immunomodulatory Effects of Water-Extractable Polysaccharides from Macrolepiota procera (Scop.) Singer

Beta-Glucan as a Novel Functional Fiber: Functional Properties, Health Benefits and Food Applications

Analysis of Biochemical and Genetic Variability of Pleurotus ostreatus Based on the β-Glucans and CDDP Markers

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