The Perspectives of Using Unimolecular Micelles in Nanodrug Formulation

Wu, Yue; Liu, Yupeng

doi:10.4155/tde-2019-0033

Cited by 12 publications

(9 citation statements)

References 20 publications

(20 reference statements)

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“…67 Unimolecular polymeric micelles are another type of interesting synthetic system where a single amphiphilic macromolecule (e.g., a star polymer chain) assembles into a micellar entity. 68,69 These unimolecular systems have unique features such as thermodynamic stability, low dispersity in micelle size, and high biocompatibility, making them attractive for drug delivery applications. 68,69 In addition to these more well-defined equilibrium structures, amphiphilic assemblies can also undergo significant transitions in morphology subject to dynamic insitu adjustment of external conditions including pH, temperature, ionic strength, and osmotic pressure.…”

Section: Experimental Observations Of Morphology Controlmentioning

confidence: 99%

“…68,69 These unimolecular systems have unique features such as thermodynamic stability, low dispersity in micelle size, and high biocompatibility, making them attractive for drug delivery applications. 68,69 In addition to these more well-defined equilibrium structures, amphiphilic assemblies can also undergo significant transitions in morphology subject to dynamic insitu adjustment of external conditions including pH, temperature, ionic strength, and osmotic pressure. 22,70,71 In situ modifications to the amphiphiles, such as changes to the chemistry of the molecules or side chain lengths, can also render similar shape transitions.…”

Section: Experimental Observations Of Morphology Controlmentioning

confidence: 99%

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Simulations of morphology control of self‐assembled amphiphilic surfactants

Zhu

Tree

2023

Journal of Polymer Science

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One of the grand challenges of amphiphilic self‐assembly is the design of ordered structures whose morphology or shape can be explicitly and dynamically controlled by adjusting the properties of the amphiphiles or their surroundings. Such a capacity would enable researchers to create synthetic systems with functionality that meets or exceeds biological cells, and provide a robust platform for a broad range of engineering applications such as artificial tissues, drug delivery, and separation membranes. Despite significant progress, important fundamental questions remain unanswered, due in part to the limited resolution and the restricted parameter spaces that are readily accessible in experiments. Computational studies thus provide an important complement to experiments, enabling in‐depth insight into underlying mechanisms and an exploration of the parameter spaces for behavior that has not yet been achieved in experiments. In this review, we briefly introduce fundamental concepts and pertinent experiments related to dynamic shape modulation in self‐assembled amphiphiles. Then, in the bulk of the review, we survey the most influential simulation studies that investigate and identify approaches to control the self‐assembled shape of amphiphiles, with an emphasis on kinetic and mechanical effects. Finally, we conclude with a perspective on future research directions in this exciting field.

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Section: Experimental Observations Of Morphology Controlmentioning

confidence: 99%

Section: Experimental Observations Of Morphology Controlmentioning

confidence: 99%

Simulations of morphology control of self‐assembled amphiphilic surfactants

Zhu

Tree

2023

Journal of Polymer Science

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“…2б). Згідно з літературними даними [32], на відміну від традиційних полімерних міцел, які формуються в процесі самооргані-зації, унімолекулярні міцели -індивідуальні сполуки, у складі яких є ядро і оболонка гідрофільної або гідрофобної природи, ковалентно зв'язані між собою [53,54]. Завдяки такій будові для унімолкулярних міцел характерна задовільна стабільність і рівномірний розподіл за розмірами в розбавлених розчинах.…”

Section: деякі характеристики Oss(n + Oh) Oss-il на його основі та їх водних розчинівunclassified

Synthesis, structure and properties of oligomeric ionic liquids of highly branched structure and special features of their self-arrangement

Шевченко¹,

Stryutsky²,

Gumenna³

et al. 2021

New Functional Substances and Materials for Chemical Engineering

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Synthesis, features of structural organization and behavior in aqueous solution of amphiphilic reactive aprotic cationic oligomeric ionic liquids obtained on the basis of a mixture of oligomeric amino- and hydroxyl-containing silsesquioxanes were considered. The dependence of the glass transition temperature, the value of ionic conductivity, self-organization in dilute aqueous solutions and the ζ-potential on the length of the alkyl substituent near the quaternary nitrogen atom in the composition of the synthesized compounds was shown. It was found that quaternization of the tertiary nitrogen atom of the starting oligomer causes a sharp decrease in the glass transition temperature. The value of the latter increases with an increase in the length of the hydrophobic alkyl fragments due to their association. In this case the ionic conductivity under anhydrous conditions decreases and at temperatures above 100°C drops by almost an order of magnitude. The maximum conductivity was reached for the oligomeric ionic liquid with the short alkyl chain and its value was 10-3 S/cm at 120oC. In dilute aqueous solutions the synthesized oligomeric ionic liquids with the short alkyl chain form aggregates with an average size of 100 nm while increasing the length of the alkyl chain prevents aggregation of silsesquioxane nuclei and leads to formation of unimolecular micelles with an average size of 3 nm

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“…In food packaging, the commonly used traditional food packaging materials polystyrene, polypropylene, and polyethylene can resist white pollution caused by degradation, so people are committed to developing a degradable environmentally friendly packaging material. In order to prevent the growth and growth of microorganisms, degradable environmentally friendly materials with antibacterial properties are gradually attracting people's attention . In biomedicine, some surgical sutures and drug delivery biomaterials must have antibacterial properties.…”

Section: Biomedicine Application Of Pha Copolymermentioning

confidence: 99%

“…In order to prevent the growth and growth of microorganisms, degradable environmentally friendly materials with antibacterial properties are gradually attracting people's attention. [141] In biomedicine, some surgical sutures and drug delivery biomaterials must have antibacterial properties. The commonly used antibacterial agents are generally metal and metal oxides, chitosan compounds, and quaternary amine compounds.…”

Section: Antibacteriamentioning

confidence: 99%

Recent Progress in Polyhydroxyalkanoates‐Based Copolymers for Biomedical Applications

Luo

Liu

et al. 2019

Biotechnology Journal

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In recent years, naturally biodegradable polyhydroxyalkanoate (PHA) monopolymers have become focus of public attentions due to their good biocompatibility. However, due to its poor mechanical properties, high production costs, and limited functionality, its applications in materials, energy, and biomedical applications are greatly limited. In recent years, researchers have found that PHA copolymers have better thermal properties, mechanical processability, and physicochemical properties relative to their homopolymers. This review summarizes the synthesis of PHA copolymers by the latest biosynthetic and chemical modification methods. The modified PHA copolymer could greatly reduce the production cost with elevated mechanical or physicochemical properties, which can further meet the practical needs of various fields. This review further summarizes the broad applications of modified PHA copolymers in biomedical applications, which might shred lights on their commercial applications.

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The Perspectives of Using Unimolecular Micelles in Nanodrug Formulation

Abstract: Together with the advantages of ease in functionalization, biodegradability and biocompatibility, unimolecular micelles could be interesting for drug delivery, bio-imaging and theranostic platform designs. "

Cited by 12 publications

References 20 publications

Simulations of morphology control of self‐assembled amphiphilic surfactants

Simulations of morphology control of self‐assembled amphiphilic surfactants

Synthesis, structure and properties of oligomeric ionic liquids of highly branched structure and special features of their self-arrangement

Recent Progress in Polyhydroxyalkanoates‐Based Copolymers for Biomedical Applications

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