“…When objective psychological instruments standardized on patients grouped phenomenologically or on the basis of psychodynamic personality constellations have been used to examine temporal lobe epileptic patients, there has been poor correspondence with established psychiatric diagnostic groups (Glaser, 1964;Mignone, Donnelly, & Sadowsky, 1970;Small & Small, 1967;Tizard, 1962). Yet, as we shall see, when the intrinsic cognitive and sensory-affective characteristics of each temporal lobe are examined from a review of patients with known unilateral temporallobe lesions, it becomes possible to infer a relationship between the spectrum of personality and behavioral characteristics of patients with disinhibited temporal lobes and a spectrum of "functional" psychopathological syndromes that include affect disorder, character pathology including aggressiveness, paranoia, obsessiveness, hysteria, and alcohol and drug addiction-perhaps representing a gradient of lost serotonergic inhibition of temporal lobe subjective phenomena as well as dopaminergic nigral-amygdaloid compulsive and aggressive behaviors (Cadoret, 1976;Gershon et al, 1975;Guze, Woodruff, & Clayton, 1972;Shields, 1975;Van Valkenburg, Lowry, Winokur, & Cadoret, 1977;Winokur & Clayton, 1966).…”