The persistence of short‐term cold acclimation in <i><scp>D</scp>rosophila melanogaster</i> (<scp>D</scp>iptera: <scp>D</scp>rosophilidae)

Everman, Elizabeth R.; Ledbetter, Nicholus M.; Morgan, Theodore J.

doi:10.1111/phen.12191

Cited by 6 publications

(7 citation statements)

References 44 publications

(75 reference statements)

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“…Additionally, this subset of the DGRP lines reached Td50 well after four weeks of age (Table S3), indicating that the four-week aging period does not include a late-life plateau in mortality for these lines (Charlesworth 2001;Curtsinger 2016). It is common when considering the survival response to acclimation and nonacclimation cold stress treatments in D. melanogaster and other small ectotherms to measure phenotypic plasticity in terms of capacity for acclimation (Lee Jr et al 1987;Sinclair and Roberts 2005;Gerken et al 2015;Jakobs et al 2015;Everman et al 2017;Noh et al 2017). This capacity for acclimation is often referred to as rapid cold-hardening (RCH) or acclimation score.…”

Section: In Stress Tolerancementioning

confidence: 99%

Antagonistic pleiotropy and mutation accumulation contribute to age‐related decline in stress response

Everman

Morgan

2018

Evolution

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As organisms age, the effectiveness of natural selection weakens, leading to age-related decline in fitness-related traits. The evolution of age-related changes associated with senescence is likely influenced by mutation accumulation (MA) and antagonistic pleiotropy (AP). MA predicts that age-related decline in fitness components is driven by age-specific sets of alleles, nonnegative genetic correlations within trait across age, and an increase in the coefficient of genetic variance. AP predicts that age-related decline in a trait is driven by alleles with positive effects on fitness in young individuals and negative effects in old individuals, and is expected to lead to negative genetic correlations within traits across age. We build on these predictions using an association mapping approach to investigate the change in additive effects of SNPs across age and among traits for multiple stress-response fitness-related traits, including cold stress with and without acclimation and starvation resistance. We found support for both MA and AP theories of aging in the age-related decline in stress tolerance. Our study demonstrates that the evolution of age-related decline in stress tolerance is driven by a combination of alleles that have age-specific additive effects, consistent with MA, as well as nonindependent and antagonistic genetic architectures characteristic of AP.

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Section: In Stress Tolerancementioning

confidence: 99%

Antagonistic pleiotropy and mutation accumulation contribute to age‐related decline in stress response

Everman

Morgan

2018

Evolution

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“…Phenotypic plasticity induced through both short‐term acclimation and longer‐term developmental acclimation has been repeatedly shown to increase survival in thermally variable environments in numerous organisms (Basson, Nyamukondiwa, & Terblanche, ; Coulson & Bale, ; Geister & Fischer, ; Hoffmann, Hallas, Dean, & Schiffer, ; Lee, Chen, & Denlinger, ; Sinclair & Chown, ). Short‐term acclimation typically occurs following a brief (minutes to hours) exposure to a nonlethal cool temperature prior to a harsher thermal stress and has ephemeral benefits on survival, wearing off after a few hours (Chen, Denlinger, & Lee, ; Czajka & Lee, ; Everman, Ledbetter, & Morgan, In Press; Gerken et al., ; Kelty & Lee, ; Koveos, ; Lee et al., ; Loeschcke & Sørensen, ). While short‐term acclimation can occur in multiple life stages (Rajamohan & Sinclair, ), developmental acclimation occurs through exposure of organisms to conditions that alter development and is thus irreversible (Lee et al., ; Teets & Denlinger, ; Wilson & Franklin, ).…”

Section: Introductionmentioning

confidence: 99%

Seasonal variation in basal and plastic cold tolerance: Adaptation is influenced by both long‐ and short‐term phenotypic plasticity

Noh

Everman

Berger

et al. 2017

Ecology and Evolution

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Understanding how thermal selection affects phenotypic distributions across different time scales will allow us to predict the effect of climate change on the fitness of ectotherms. We tested how seasonal temperature variation affects basal levels of cold tolerance and two types of phenotypic plasticity in Drosophila melanogaster. Developmental acclimation occurs as developmental stages of an organism are exposed to seasonal changes in temperature and its effect is irreversible, while reversible short-term acclimation occurs daily in response to diurnal changes in temperature. We collected wild flies from a temperate population across seasons and measured two cold tolerance metrics (chill-coma recovery and cold stress survival) and their responses to developmental and short-term acclimation. Chill-coma recovery responded to seasonal shifts in temperature, and phenotypic plasticity following both short-term and developmental acclimation improved cold tolerance. This improvement indicated that both types of plasticity are adaptive, and that plasticity can compensate for genetic variation in basal cold tolerance during warmer parts of the season when flies tend to be less cold tolerant. We also observed a significantly stronger trade-off between basal cold tolerance and short-term acclimation during warmer months. For the longer-term developmental acclimation, a trade-off persisted regardless of season. A relationship between the two types of plasticity may provide additional insight into why some measures of thermal tolerance are more sensitive to seasonal variation than others. K E Y W O R D Sacclimation, daily temperature, developmental plasticity, evolutionary constraint, seasonal temperature

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“…melanogaster lines established by sampling naturally segregating genetic variation in a single population in Raleigh, North Carolina [ 48 , 49 ]. Nineteen lines were selected from the DGRP that have been previously shown to vary in cold tolerance and RCH capacity [ 31 , 48 ]. We chose a subset of nineteen lines from the DGRP to perform detailed analyses of courtship behavior and song (discussed below).…”

Section: Methodsmentioning

confidence: 99%

“…Each pair was observed for four hours at 25°C in vials containing media and activated yeast because the effects of acclimation have been demonstrated to last between four and eight hours in D . melanogaster [ 3 , 31 ].…”

Section: Methodsmentioning

confidence: 99%

“…Although RCH has beneficial effects on physiological metrics of cold tolerance, this response is also genetically variable, and not all genotypes benefit from RCH [ 12 , 31 , 33 ]. Further, the response to acclimation through RCH, quantified as RCH capacity, varies across environments [ 18 , 32 ], and benefits from RCH for survival do not necessarily imply uniform benefits of RCH for other components of fitness [ 4 , 12 , 34 ].…”

Section: Introductionmentioning

confidence: 99%

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Costs of cold acclimation on survival and reproductive behavior in Drosophila melanogaster

et al. 2018

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Fitness is determined by the ability of an organism to both survive and reproduce; however, the mechanisms that lead to increased survival may not have the same effect on reproductive success. We used nineteen natural Drosophila melanogaster genotypes from the Drosophila Genetic Reference Panel to determine if adaptive plasticity following short-term acclimation through rapid cold-hardening (RCH) affects mating behavior and mating success. We confirmed that exposure to the acclimation temperature is beneficial to survival following cold stress; however, we found that this same acclimation temperature exposure led to less efficient male courtship and a significant decrease in the likelihood of mating. Cold tolerance and the capacity to respond plastically to cold stress were not correlated with mating behavior following acclimation, suggesting that the genetic control of the physiological effects of the cold temperature exposure likely differ between survival and behavioral responses. We also tested whether the exposure of males to the acclimation temperature influenced courtship song. This exposure again significantly increased courtship duration; however, courtship song was unchanged. These results illustrate costs of short-term acclimation on survival and reproductive components of fitness and demonstrate the pronounced effect that short-term thermal environment shifts can have on reproductive success.

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The persistence of short‐term cold acclimation in Drosophila melanogaster (Diptera: Drosophilidae)

Cited by 6 publications

References 44 publications

Antagonistic pleiotropy and mutation accumulation contribute to age‐related decline in stress response

Antagonistic pleiotropy and mutation accumulation contribute to age‐related decline in stress response

Seasonal variation in basal and plastic cold tolerance: Adaptation is influenced by both long‐ and short‐term phenotypic plasticity

Costs of cold acclimation on survival and reproductive behavior in Drosophila melanogaster

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