The Persistence of Electron Spin Resonance in Bone Grafts Sterilized by Ionizing Radiation

Slager, Ursula T.; Zucker, Melvin J.; Reilly, Emmett B.

doi:10.2307/3571741

Cited by 23 publications

(9 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The exposure of mineralised tissues of bone and teeth to ionising radiation results in the induction of free radicals and other paramagnetic entities that can be detected by electron paramagnetic resonance (EPR, ESR) spectrometry (Cole and Silver 1963;Slager et al 1964;Swartz 1965;Termine et al 1967;Fischer et al 1971;Houben 1971).…”

Section: Interdisciplinary Researchmentioning

confidence: 99%

Irradiation as a Safety Procedure in Tissue Banking

Dziedzic‐Goclawska

Kamiński

Uhrynowska-Tyszkiewicz

et al. 2005

Cell Tissue Banking

168

118

View full text Add to dashboard Cite

The Central Tissue Bank in Warsaw was established in 1963 and since then ionising radiation has been routinely applied to sterilise tissue grafts. Connective tissue grafts such as bone, cartilage, tendons, sclera, pericardium, skin, acellular dermis and amnion irradiated with a dose of 35 kGy in a (60)Co source and/or with an electron beam 10 MeV accelerator are prepared in our Tissue Bank and two other multi-tissue banks operating in Poland. Over 250,000 radiation-sterilised tissue grafts have been prepared and used in hospitals throughout Poland and no infectious disease transmission or other adverse post-transplantation reactions have been reported up to today. It should be kept in mind however, that high doses of ionising radiation can evoke numerous chemical and physical changes that may affect the biological quality of tissue allografts. Therefore, interdisciplinary research has been undertaken at the Central Tissue Bank in Warsaw to establish the origin and stability of free radicals and other paramagnetic entities induced by irradiation in bone. The effects of various preservation procedures (e.g. lyophilisation, deep-freezing) and irradiation conditions (doses, temperature of irradiation) on the osteoinductive potential and mechanical properties of bone and on the degradation of collagen, a major constituent of all connective tissue grafts, have been also studied. The results of these studies indicate that radiation-induced changes can be diminished by modification of tissue preservation methods and that, to some extent, it is possible to reduce undesired radiation-induced damage to the tissue grafts.

show abstract

Section: Interdisciplinary Researchmentioning

confidence: 99%

Irradiation as a Safety Procedure in Tissue Banking

Dziedzic‐Goclawska

Kamiński

Uhrynowska-Tyszkiewicz

et al. 2005

Cell Tissue Banking

168

118

View full text Add to dashboard Cite

show abstract

“…A long-lived ESR signal was first observed in X-irradiated biologically significant materials such as alanine and bone by Gordy and Shields (33) and subsequently studied by Blyumenfel'd and Kalmanson (34). ESR signals from hydroxyapatite were then explored more thoroughly by several groups (4,5); ESR in irradiated dental enamel was reported by Cole and Silver (15).…”

Section: Biophysical Dosimetry Using Electron Spin Resonance In Biolomentioning

confidence: 99%

“…ESR can be used to measure the absorption of electromagnetic (microwave) radiation by these free radicals. The magnitude of this absorption is proportional to the number of free radicals and thus gives a measure of absorbed dose (4,5,7,8,10,39 (40)(41)(42).…”

Section: Biophysical Dosimetry Using Electron Spin Resonance In Biolomentioning

confidence: 99%

See 1 more Smart Citation

Collective Radiation Biodosimetry for Dose Reconstruction of Acute Accidental Exposures: A Review

Pass

1997

Environmental Health Perspectives

View full text Add to dashboard Cite

Quantification of the biologically relevant dose is required to establish cause and effect between radiation detriment or burden and important biological outcomes. Most epidemiologic studies of unanticipated radiation exposure fail to establish cause and effect because researchers have not been able to construct a valid quantification of dose for the exposed population. However, no one biodosimetric technique (biophysical or biological) meets all the requirements of an ideal dosimeter. This paper reviews how the collection of biodosimetric data for victims of radiation accidents can be used to create a dosimetric "gold standard." Particular emphasis is placed on the use of electron spin resonance, a standard for radiation accident dosimetry. As an example of this technique, a review will be presented of a previously reported study of an individual exposed to a 60Co sterilization source.

show abstract

“…This is the reason why the alanine dosimeter for an intermediate-dose range has been developed to monitor the absorbed dose. Food spoilage and contamination of foods with pathogens can be prevented by radiation processing (Slager et al 1964). Traditional methods of processing and preserving foods have been drying, fermentation, pickling, pasteurization and canning in addition to using preservatives, inert gas and oxygen absorptive chemicals.…”

Section: Dosimetry For Food Irradiationmentioning

confidence: 99%

ESR Dosimetry: Dosimeter, Accident Dose and Foodstuffs

Ikeya¹

1993

New Applications of Electron Spin Resonance

View full text Add to dashboard Cite

ESR can be used as a radiation dosimeter in nuclear facilities using alanine, sugar and other tissue equivalent organic materials. Anew material with a high G-value and a sharp linewidth is strongly hoped for. Accident dosimetry of direct exposure to human beings can be made by measuring human tooth enamel and shell buttons. Some food irradiation doses can also be checked with ESR.-395 -New Applications of Electron Spin Resonance Downloaded from www.worldscientific.com by KAINAN UNIVERSITY on 02/19/15. For personal use only. New Applications of Electron Spin Resonance Downloaded from www.worldscientific.com by KAINAN UNIVERSITY on 02/19/15. For personal use only. New Applications of Electron Spin Resonance Downloaded from www.worldscientific.com by KAINAN UNIVERSITY on 02/19/15. For personal use only. Appl. Radiat. Isot. 52,1197-1202.Desrosiers M. F. and Simic M. G. (1988): Post-irradiation dosimetry of meat by electron spin resonance spectroscopy of bones. : Use of ESR to identify irradiated food. Radiat. Phys. Chem. 26,451-453. Dodd N. J. E, Lea J. S. and Swallow A J. (1988b): ESR detection of irradiated food. Nature 334,387. Dorda D. M. (1989): Dose control in the semi-industrial irradiation plant at Ezeiza Atomic Center. Appl Radiat. Isot. 40,1009-1012. Duran J. E. R., Panzeri H. and Mascarenhas S. (1985): ESR dosimetry of irradiation human New Applications of Electron Spin Resonance Downloaded from www.worldscientific.com by KAINAN UNIVERSITY on 02/19/15. For personal use only.

show abstract

The Persistence of Electron Spin Resonance in Bone Grafts Sterilized by Ionizing Radiation

Cited by 23 publications

References 12 publications

Irradiation as a Safety Procedure in Tissue Banking

Irradiation as a Safety Procedure in Tissue Banking

Collective Radiation Biodosimetry for Dose Reconstruction of Acute Accidental Exposures: A Review

ESR Dosimetry: Dosimeter, Accident Dose and Foodstuffs

Contact Info

Product

Resources

About