1979
DOI: 10.1097/00005072-197905000-00005
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The Persistence and Possible Externalization of Axonal Debris During Wallerian Degeneration

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Cited by 22 publications
(8 citation statements)
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“…In control mice, on the other hand, neurofilament degradation and the disappearance of the CAP appear to be simultaneous and very difficult to dissociate due to the rapidity of Wallerian degeneration. Previous work by Schlaepfer and colleagues (Schlaepfer, 1974(Schlaepfer, , 1977Schlaepfer and Micko, 1978;Schlaepfer and Hasler, 1979;Schlaepfer and Zimmerman, 1984; has shown that axonal and, in particular, neurofilament degradation is dependent on calcium ions. Schlaepfer and Zinlmerman (1984) also noted that the destruction of the axonal cytoskeleton, specifically the neurofilaments, is directly associated with the collapse and fragmentation of the surrounding myelin sheath.…”
Section: (In Vivo) (In Vivo) (In Virro) (In Vivo)mentioning
confidence: 99%
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“…In control mice, on the other hand, neurofilament degradation and the disappearance of the CAP appear to be simultaneous and very difficult to dissociate due to the rapidity of Wallerian degeneration. Previous work by Schlaepfer and colleagues (Schlaepfer, 1974(Schlaepfer, , 1977Schlaepfer and Micko, 1978;Schlaepfer and Hasler, 1979;Schlaepfer and Zimmerman, 1984; has shown that axonal and, in particular, neurofilament degradation is dependent on calcium ions. Schlaepfer and Zinlmerman (1984) also noted that the destruction of the axonal cytoskeleton, specifically the neurofilaments, is directly associated with the collapse and fragmentation of the surrounding myelin sheath.…”
Section: (In Vivo) (In Vivo) (In Virro) (In Vivo)mentioning
confidence: 99%
“…, 1976), during which time the axons disintegrate. Observations on neurofilaments during Wallerian degeneration indicate that neurofilament immunoreactivity decreases concomitantly (Schlaepfer and Micko, 1978;Schlaepfer and Hasler, 1979;Schlaepfer and Zimmerman, 1984;Schlaepfer e t a l . , 1984).…”
Section: Introductionmentioning
confidence: 99%
“…Indeed, later events such as Wallerian degeneration and demyelination might be responsible for the irreversible functional loss after decompression. 4,7,[26][27][28] Such phenomena should be further investigated in future studies that link mechanical trauma to secondary cascades in compressive SCI.…”
Section: Limitations Of the Current Modelmentioning
confidence: 99%
“…Trojanowski JQ, Lee VM-Y, Schlaepfer WW: Neurofilament breakdown products in degenerating rat and human peripheral nerves. Ann Neurol 16:349-355, 1984 The factors that determine the response of neurons to axonal injury remain undefined {l, 2, 8, [21][22][23]. Axonal regeneration may be initiated by the retrograde transport of trophic factors or metabolites from the periphery Ell, 123.…”
mentioning
confidence: 99%