The permeability of the hypophysis and hypothalamus to vital dyes, with a study of the hypophyseal vascular supply

Wislocki, George B.; King, Lester S.

doi:10.1002/aja.1000580206

Cited by 338 publications

(52 citation statements)

References 11 publications

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“…According to this concept blood entered and left the neural lobe by these routes and the circulations of the median eminence and the neural lobe were anatomically and functionally separate and distinct (48). In this classical scheme ( Figure 4A), the median eminence vasculature was the final common pathway through which data, transforthed from neural impulses into neurohormones, was conveyed to the pars distalis.…”

Section: Pituitary Blood Flowsupporting

confidence: 42%

“…In 1936 the classical scheme of pituitary blood flow for mammals ( Figure 4A means by which the pituitary may influence brain function (48). The scheme proposed that blood flowed from rostral hypophyseal arteries into the median eminence primary capillary network and passed by the portal vessels to the pars distalis, leaving it by systemic lateral hypophyseal veins coursing from the pars distalis to the cavernous sinus.…”

Section: Pituitary Blood Flowcontrasting

confidence: 39%

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Hypophysectomy in dogs: A review

Meij

1999

Veterinary Quarterly

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Section: Pituitary Blood Flowsupporting

confidence: 42%

Section: Pituitary Blood Flowcontrasting

confidence: 39%

Hypophysectomy in dogs: A review

Meij

1999

Veterinary Quarterly

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“…; Xuereb et al, 1954aXuereb et al, , 1954bGreen, 1957;Stanfield, i960), in the monkey (Wislocki and King, 1936;Wislocki, 1938aWislocki, , 1938bHolmes and Zuckerman, 1959), in the sheep Prichard, 1957a, 1957b;Baldwin, 1964), in the goat (Daniel and Prichard, 1958;Adams £t 1964b), in the horse (Baldwin, 1964;BrettSchneider, 1955), in cattle (Baldwin and Bell, 196O; Dellmann, I960; Baldwin, 1964;Cummings and Habel, 1966), in the cat (Wislocki and King, 1936;Wislocki, 1937c;Green and Harris, 1947; Torok, 196O; Szentagothai e^^., I968), in the rabbit (Wislocki and King, 1936;Harris, 1947), in the rat (Green and Harris, (Green, 1951;Daniel, 1966). In species where the internal carotid artery remained patent in the adult animals, it was estab lished that the rostral hypophysial arteries took their origin from the intra-arachnoid portion of the internal carotid or from the caudal communicating artery (Basir, 1932;Torok, 1964;Stanfield, 196O).…”

Section: Omentioning

confidence: 43%

Quantitative and histomorphological studies on age-correlated changes in canine and porcine hypophysis

Das

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“…Tumor resection was accomplished by circumferential dissection of the pseudocapsule in most cases. Consistent with prior observations, 1,2,3,6,8 histological evidence of dural invasion was common, occurring in 34% of patients. Of note, 7% of patients had dural invasion of the anterior sella without apparent gross surgical invasion.…”

Section: Swedish Neuroscience Institute Seattle Washingtonmentioning

confidence: 43%

Editorial: Invasion of the corticotrophs

Mayberg¹

2012

JNS

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Lonser and colleagues 4 performed a prospective observational analysis to determine the incidence, location, and tumor characteristics of dural invasion associated with corticotropic pituitary adenomas. Eighty-seven consecutive pediatric and adult patients with Cushing disease at a single institution underwent a procedure in which the anterior dura was routinely resected and the medial cavernous sinus wall was resected when dural invasion was encountered. The uncoagulated dural specimens were processed for adrenocorticotropic hormone immunohistochemistry and were compared with highresolution MR imaging determinations. Tumor resection was accomplished by circumferential dissection of the pseudocapsule in most cases. Consistent with prior observations, 1,2,3,6,8 histological evidence of dural invasion was common, occurring in 34% of patients. Of note, 7% of patients had dural invasion of the anterior sella without apparent gross surgical invasion. Dural invasion occurred most frequently at the cavernous sinus, but also along the anterior, inferior, and posterior dura of the sella. Magnetic resonance imaging was a poor predictor of dural invasion, correctly identifying cavernous sinus invasion in only 22% of cases. Tumor size was related to invasion, yet many small tumors adjacent to the dura were invasive. In contrast to prior studies, 6 there was no apparent increase in dural invasion with age.There are several important observations in this study. First, the authors have confirmed the high frequency of dural invasion in a prospective consecutive series of patients with Cushing disease. Proximity of the tumor to dura seems to be the most important factor for invasion, and MR imaging is a poor diagnostic test to identify invasion. Even direct observation of dural invasion was inaccurate in a small number of cases. Second, dural invasion can occur at various sites within the sella, not only the cavernous sinus, as might be expected. Third, the authors' approach of extracapsular tumor dissection and resection of adjacent dura, combined with reexploration when immediate postoperative serum cortisol levels remain normal or elevated, resulted in an immediate biochemical remission rate of 98% and no early recurrences. Although this series is not controlled, the immediate remission rate is higher than that achieved in most larger studies by experienced pituitary surgeons.

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The permeability of the hypophysis and hypothalamus to vital dyes, with a study of the hypophyseal vascular supply

Cited by 338 publications

References 11 publications

Hypophysectomy in dogs: A review

Hypophysectomy in dogs: A review

Quantitative and histomorphological studies on age-correlated changes in canine and porcine hypophysis

Editorial: Invasion of the corticotrophs

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