The permeability of kidney cortex to chloride

Whittam, R.

doi:10.1113/jphysiol.1956.sp005481

Cited by 56 publications

(21 citation statements)

References 28 publications

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“…This consideration would hold if C1 were passively distributed across the cell membrane. Bath to cell Cl concentration ratios between 1.5 and 4 have been reported (21,31,32,11) and we have obtained in preliminary experiments ratios between 1.3 and 2 at an external K concentration of 5.3 mmole/kg. These ratios are significantly lower than those expected from a passive distribution of Cl.…”

Section: The Possibility That Some K Is Bound Within the Cellsmentioning

confidence: 85%

Sodium Extrusion and Potassium Uptake in Guinea Pig Kidney Cortex Slices

Whittembury

1965

The Journal of General Physiology

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Slices from the cortex corticis of the guinea pig kidney were immersed in a chilled solution without K and then reimmersed in warmer solutions. The Na and K concentrations and the membrane potential V,,, were then studied as a function of the Na and K concentrations of the reimmersion fluid. It was found that Na is extruded from the cells against a large electrochemical potential gradient. Q0 for net Na outflux was -2.5. At bath K concentrations larger than 8 mM the behavior of K was largely passive. At the outset of reimmersion (Vm > Ej) K influx seemed secondary to Na extrusion. Na extrusion would promote K entrance, being limited and requiring the presence of K in the bathing fluid. At bath K concentrations below 8 m, K influx was up an electrochemical potential gradient. Thus a parallel active K uptake is apparent. Qo0 for net K influx was -2.0. Dinitrophenol inhibited net Na outflux and net K influx, Q o became <1.1 for both fluxes. The ratio between these fluxes varied. Thus at the outset of reimmersion the net Na outflux to net K influx ratio was > 1. After 8 minutes it was < 1.

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Section: The Possibility That Some K Is Bound Within the Cellsmentioning

confidence: 85%

Sodium Extrusion and Potassium Uptake in Guinea Pig Kidney Cortex Slices

Whittembury

1965

The Journal of General Physiology

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“…There exist no direct studies of medullary Cl-content or distribution comparable with those which have been carried out on renal cortical slices (Whittam, 1956;Kleinzeller & Knotkova, 1964; Macknight, 1968; Whittembury & Proverbio, 1970;Proverbio & Whittembury, 1975).…”

Section: Introductionmentioning

confidence: 99%

Factors affecting the distribution of chloride ions in rat renal outer medulla.

Law¹

1977

The Journal of Physiology

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“…Seminal vesicle mucosa slices were incubated for 30 min in ordinary non-radioactive saline solution and then transferred to another saline solution containing 42K; the uptake of 42K by the tissue during the following 100 min was measured in aerobic and anaerobic conditions at 370 C. The results of a semi-logarithmic plot of the data are shown in Fig. 3 (see Whittam (1956) for details of the method of plotting). In each condition a fairly fast exchange (rate constant about 0 04 min-1) occurred during the first 7 min but thereafter the rate of (,umole/g tissue) 105-0±5-0 (7) 105-0±8-5 (6) 102-0±9-5 (7) 1-0±0-6 (5) 76-0±2-5 (8) 8-0±0-7…”

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confidence: 99%

Ion movements in seminal vesicle mucosa

Breuer¹,

Whittam²

1957

The Journal of Physiology

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The testicular hormone, testosterone, is required by the seminal vesicles for the production of fructose, citric acid and other characteristic chemical constituents of the vesicular secretion (see Mann, 1954), and also appears to influence the distribution of water in the gland. Thus, after the injection of testosterone propionate in castrated rats the extracellular water of the seminal vesicle tissue was reduced about threefold, almost to the value of 138 % found in normal, i.e. non-castrated, rats (Rudolph & Starnes, 1954a). The rate of respiration of the tissue from rats treated in this way was also affected; it increased about 30 %, again to the level characteristic of the vesicles from normal rats (Rudolph & Starnes, 1954b).The seminal vesicles of the guinea-pig are different anatomically from those of rats and are shaped in the form of a wide duct which can be opened and the mucosa then conveniently separated as a sheet of tissue. Levey & Szego (1955 a) used such pieces of tissue in a comparison of the metabolism of seminal vesicle epithelia from normal and castrated guinea-pigs, and found that in the latter case the respiration was only a half that of normal tissue or of tissue from castrated animals which had been injected with testosterone. In view of the effects of castration and of testosterone on the water content and respiration of seminal vesicles, a study has been made of the relation between metabolism and the movements of water and ions in the seminal vesicle mucosa of the normal guinea-pig. The concentrations of sodium, potassium and chloride in the tissue, after incubation under various conditions, have been measured and the conclusion has been reached that the tissue can maintain ionic concentration gradients so long as either respiratory or glycolytic energy is available.

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The permeability of kidney cortex to chloride

Cited by 56 publications

References 28 publications

Sodium Extrusion and Potassium Uptake in Guinea Pig Kidney Cortex Slices

Sodium Extrusion and Potassium Uptake in Guinea Pig Kidney Cortex Slices

Factors affecting the distribution of chloride ions in rat renal outer medulla.

Ion movements in seminal vesicle mucosa

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