The Permeability of Blood Capillary Sprouts and Newly Formed Blood Capillaries as Compared to That of Older Blood Capillaries

Abell, Richard G.

doi:10.1152/ajplegacy.1946.147.2.237

Cited by 47 publications

(8 citation statements)

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“…At day 2 no changes had been observed, however at day 4 a significant increase of VEGF was found. This increase might be explained by the beginning process of wound healing tissue regeneration, since several authors described increased levels of VEGF in this context [30][31][32]. It is conspicuous, that the systemically increased serum-levels of VEGF only influence the peritoneal vessels but obviously not the complete periphery.…”

Section: Discussionmentioning

confidence: 97%

VEGF induces ascites in ovarian cancer patients via increasing peritoneal permeability by downregulation of Claudin 5

Herr¹,

Sallmann²,

Bekes³

et al. 2012

Gynecologic Oncology

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Section: Discussionmentioning

confidence: 97%

VEGF induces ascites in ovarian cancer patients via increasing peritoneal permeability by downregulation of Claudin 5

Herr¹,

Sallmann²,

Bekes³

et al. 2012

Gynecologic Oncology

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“…Newly grown capillaries, in rabbit ear chambers, have a much higher blood flow and greater permeability to the albumin-bound dye, Evan's Blue, than do mature capillaries [15]. These high K f values might reflect the relatively increased permeability of growing capillaries and changes in microvascular density associated with growth.…”

Section: Discussionmentioning

confidence: 99%

Age-related changes in microvascular permeability: a significant factor in the susceptibility of children to shock?

et al. 2000

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During studies of the pathogenesis of dengue shock syndrome, a condition largely confined to childhood and characterized by a systemic increase in vascular permeability, we observed that healthy controls, age-matched to children with dengue shock syndrome, gave high values of filtration capacity (K(f)), a factor describing vascular permeability. We hypothesized that K(f) might be age dependent. Calf K(f) was studied in 89 healthy Vietnamese subjects aged 5 to 77 years. The K(f) was highest in the youngest children [7. 53 (1.96-15.46) K(f)U; median (range); where the units of K(f), K(f)U=ml.min(-1).100 ml(-1).mmHg(-1)]. Values were 3- to 4-fold lower towards the end of the second decade [4.69 (1.91-7.06) K(f)U]. Young mammals are known to have a larger microvascular surface area per unit volume of skeletal muscle than adults. During development the proportion of developing vessels is greater. Moreover, the novel microvessels are known to be more permeable to water and plasma proteins than when mature. These factors may explain why children more readily develop hypovolaemic shock than adults in dengue haemorrhagic fever and other conditions characterized by increased microvascular permeability.

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“…Generation of new blood vessels from pre‐existing vasculature (angiogenesis) is accompanied in almost all states by increases in vascular permeability. This was shown in physiological angiogenesis in the 1940s using large‐molecular‐weight dyes in wound healing (Abell, 1946), as well as in angiogenesis in the developing tail of immature amphibians (Clark & Clark, 1935). A more detailed ultrastructural study in 1963 showed that large‐molecular‐weight tracers such as colloidal carbon leaked out of growing capillaries in wound healing models (Schoefl, 1963).…”

Section: Vascular Permeability and Angiogenesismentioning

confidence: 99%

Regulation of microvascular permeability by vascular endothelial growth factors*

et al. 2002

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Generation of new blood vessels from pre-existing vasculature (angiogenesis) is accompanied in almost all states by increased vascular permeability. This is true in physiological as well as pathological angiogenesis, but is more marked during disease states. Physiological angiogenesis occurs during tissue growth and repair in adult tissues, as well as during development. Pathological angiogenesis is seen in a wide variety of diseases, which include all the major causes of mortality in the west: heart disease, cancer, stroke, vascular disease and diabetes. Angiogenesis is regulated by vascular growth factors, particularly the vascular endothelial growth factor family of proteins (VEGF). These act on two specific receptors in the vascular system (VEGF-R1 and 2) to stimulate new vessel growth.VEGFs also directly stimulate increased vascular permeability to water and large-molecular-weight proteins. We have shown that VEGFs increase vascular permeability in mesenteric microvessels by stimulation of tyrosine autophosphorylation of VEGF-R2 on endothelial cells, and subsequent activation of phospholipase C (PLC). This in turn causes increased production of diacylglycerol (DAG) that results in influx of calcium across the plasma membrane through store-independent cation channels. We have proposed that this influx is through DAG-mediated TRP channels. It is not known how this results in increased vascular permeability in endothelial cells in vivo. It has been shown, however, that VEGF can stimulate formation of a variety of pathways through the endothelial cell, including transcellular gaps, vesiculovacuolar organelle formation, and fenestrations. A hypothesis is outlined that suggests that these all may be part of the same process.

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The Permeability of Blood Capillary Sprouts and Newly Formed Blood Capillaries as Compared to That of Older Blood Capillaries

Cited by 47 publications

References 0 publications

VEGF induces ascites in ovarian cancer patients via increasing peritoneal permeability by downregulation of Claudin 5

VEGF induces ascites in ovarian cancer patients via increasing peritoneal permeability by downregulation of Claudin 5

Age-related changes in microvascular permeability: a significant factor in the susceptibility of children to shock?

Regulation of microvascular permeability by vascular endothelial growth factors*

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