The Peripheral Vascular Dynamics of Bowel Function

Halpern, Alfred; Selman, David; Shaftel, Norman; Samuels, Saul S.; Shaftel, Herbert E.; Kühn, P

doi:10.1097/00000441-195904000-00005

Cited by 7 publications

(2 citation statements)

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“…In their discussion, the authors suggested the formation of a diconjugated ketone: dibenzosuberone (SH-dibenzo-lO,l I-dihydro-[a,d]cyclohepten-5-one) (It). This chemical was also isolated by Henwood (2). This author detected the compound as a result of the autoxidation of amitriptyline base.…”

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confidence: 91%

Anthraquinone, a New Chemical Oxidation Product of Amitriptyline

Bouche

1972

Journal of Pharmaceutical Sciences

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confidence: 91%

Anthraquinone, a New Chemical Oxidation Product of Amitriptyline

Bouche

1972

Journal of Pharmaceutical Sciences

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“…The cardinal risks of geriatric constipation include sudden circulatory changes on straining at stool, particularly when a bed pan is used (1–4). The threat of sudden death due to these stresses is greatest in the presence of serious organic heart disease (3, 4) which is so common in older persons.…”

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confidence: 99%

Regulation of Bowel Function by a Laxative/Stool Softener Preparation in Aged Nursing Home Patients

Maddi

1979

J American Geriatrics Society

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A 12-week program for 42 chronically constipated patients in a nursing home involved a graduated dosage regimen of standardized senna concentrate with dioctyl sodium sulfosuccinate (Senokot-S Tablets), a high-fiber diet, and an increased fluid intake. The program achieved a satisfactory pattern of bowel evacuation in 36 (86 percent) of these patients. This pattern, as observed during a 4-week follow-up period while therapy was continued, was characterized by absence of fecal impactions, regular comfortable bowel movements of appropriate consistency, minimal or no straining at stool, and minimal or no resort to enemas. In the initial 2-week control period, none of the 42 patients had responded adequately to only dietary modification and increased hydration. Six additional patients whose response to the control regimen was equivocal, also appeared to benefit from the medication program. Two of these were able to discontinue the laxative tablets completely by the end of the 12-week test period. None of the 48 patients who completed the course experienced any adverse effects related to this rehabilitative program.

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The origin of phleboliths

Shemilt

1972

Journal of British Surgery

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Phleboliths originate as thrombi in the pelvic veins and are the result of injury to the vein wall. Although in children the pelvic veins and venous plexuses may be protected by valves, these have disappeared in adult life. In 20 dissections in adult cadavers remnants of osteal valves were sometimes seen, but a functioning bicuspid valve was noted only once. These unprotected veins are subjected to large and abrupt rises in pressure during normal acts of coughing and straining. Because of this the veins are distended and damage to the intima with the formation of a protective thrombus can occur. A locally high concentration of phosphatase in the perivesical tissues would explain why these thrombi become calcified in the pelvis and why phleboliths are so rarely found elsewhere.

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The Peripheral Vascular Dynamics of Bowel Function

Cited by 7 publications

References 0 publications

Anthraquinone, a New Chemical Oxidation Product of Amitriptyline

Anthraquinone, a New Chemical Oxidation Product of Amitriptyline

Regulation of Bowel Function by a Laxative/Stool Softener Preparation in Aged Nursing Home Patients

The origin of phleboliths

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