The Peripheral Nerve Function in Chronic Renal Failure

Vk, Nielsen

doi:10.1111/j.0954-6820.1974.tb00972.x

Cited by 26 publications

(4 citation statements)

References 7 publications

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“…Neuromuscular fatigability assessment. The protocol focused on measuring the isometric force of the dominant finger flexor muscles because this is the muscle group most commonly studied in the clinical setting (27) and is less prone to vascular and neuropathic complications (28). In addition, the neuromuscular fatigability as assessed using the handgrip task can be considered representative to the neuromuscular fatigability obtained in the lower limb muscles (29).…”

Section: Methodsmentioning

confidence: 99%

“…The reduction in the intracellular pH induced by H + accumulation seems to induce a modification in muscle action potential, leading to reductions in both nerve conduction velocity and sEMG frequency (46). CKD patients stages 3b-5 are already known to have a reduced nerve conduction velocity because of uremic toxins and Na/K-ATPase dysfunction (28). In addition, they are more prone to develop muscle acidosis at matched absolute exercise intensity than controls, which contributes to neuromuscular fatigability (6,41).…”

Section: Mfi-20 and Facit-f Supports Consistency Of Both Measures In ...mentioning

confidence: 99%

“…Finger flexor muscles are not considered as a functional muscle group. However, the very high prevalence of peripheral neuropathy (52), together with recommendations in neurophysiological testing in these patients (28), led the authors to test upper limbs, for which the handgrip task is the most widely used modality in CKD patients (27). In addition, albeit unclear, it seems that neuromuscular fatigability and its etiology might be interrelated between muscle groups and therefore representative of the individual neuromuscular fatigability (29).…”

Section: Mfi-20 and Facit-f Supports Consistency Of Both Measures In ...mentioning

confidence: 99%

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Neural Drive Impairment in Chronic Kidney Disease Patients Is Associated with Neuromuscular Fatigability and Fatigue

Chatrenet

Piccoli

Anthierens

et al. 2022

Medicine &Amp; Science in Sports &Amp; Exercise

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Introduction: Chronic kidney disease (CKD) patients have a high degree of fatigue relating to neuromuscular symptoms. There is a lack of evidence regarding the etiology of neuromuscular fatigability in elderly CKD patients. Methods: Inclusion criteria are as follows: age ≥60 yr, glomerular filtration rate (GFR) <45 mL•min −1 per 1.73 m 2 in CKD patients, and GFR >60 mL•min −1 •1.73 m −2 in controls. The fatigability protocol consisted in a submaximal handgrip task at 40% peak force. Fatigue was assessed using the Multidimensional Fatigue Inventory-20 items (MFI-20) and the Functional Assessment of Chronic Illness Therapy-Fatigue questionnaires. Peak rate of force development (RFD peak , normalized: NRFD peak ) and rate of EMG rise (RER) were measured during explosive contractions; peak force and mean surface EMG were measured during maximum voluntary contractions. Multilevel models tested neuromuscular parameters adjusted for clinical and Multidimensional Fatigue Inventory-20 items subscales. Neuromuscular fatigability contribution to fatigue description was tested using model comparison. Results: The study included 102 participants; 45 CKD patients and 57 controls. CKD mainly affected the mental and the reduced motivation subscales of fatigue. CKD was associated with greater neuromuscular fatigability assessed using NRFD peak (group-time interaction, −16.7 % MVF•s −1 , P = 0.024), which increased with fatigue severity ( P = 0.018) and with a higher rate of decrement in RER compared with controls (RER at 50 ms: β = −121.2 μV•s −1 , P = 0.016, and β = −48.5 μV•s −1 , P = 0.196, respectively). Furthermore, these patients show an association between the reduced motivation subscale and the RER (e.g., 30 ms: β = −59.8% EMG peak •s −1 , P < 0.001). Only peak force fatigability contributed to fatigue variance, whereas RFD peak did not. Conclusions: In CKD patients, the neuromuscular fatigability assessed using RFD peak is related to an impairment in motor-unit recruitment or discharge rates, whereas only peak force fatigability was related to fatigue. This suggests that targeting exercise interventions might lessen fatigue and improve quality of life in CKD patients.

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Section: Methodsmentioning

confidence: 99%

Section: Mfi-20 and Facit-f Supports Consistency Of Both Measures In ...mentioning

confidence: 99%

Section: Mfi-20 and Facit-f Supports Consistency Of Both Measures In ...mentioning

confidence: 99%

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Neural Drive Impairment in Chronic Kidney Disease Patients Is Associated with Neuromuscular Fatigability and Fatigue

Chatrenet

Piccoli

Anthierens

et al. 2022

Medicine &Amp; Science in Sports &Amp; Exercise

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“…In human subjects the evoked response and conduction velocity of the median nerve were thoroughly investigated by Buchthal & Rosenfalck (1966 liver (Nielsen & Kardel 1972) and kidney (Nielsen 1973b(Nielsen , 1974 diseases, a decrease in conduction velocity of the median nerve took place and the decrease occurred progressively as a function of time and as a function of conduction distances. However, since fiber components (such as A-beta, A-delta and C ) could not be readily differentiated in the compound action potential recorded from the median nerve in human volunteers, as reported by Nielsen & Kardel (1974), it was difficult to relate the rate of decrement of conduction with different fiber components in the nerve.…”

mentioning

confidence: 99%

Decremental conduction in a mammalian peripheral nerve

2009

Acta Neurologica Scandinavica

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Conduction velocities of the A‐beta, A‐delta and C‐fibers in isolated vagal nerves were measured before, during, and after the nerve was exposed to sodium‐deficient hypotonic solutions. The solution was kept at 230C. Recorded at a conduction distance of 18 mm and with the nerve in a 0.25% NaCl solution, the conduction velocity of the A‐beta component in the response was found to decrease at an average rate of 1.07 m/s per min; of the A‐delta, 0.35 m/s per min and of the C‐fibers, 0.020 m/s per min. Thus, the A‐delta component in the response would disappear in about 29 min; the C‐component, in 49 min; and the A‐beta component, in 54 min. Recorded at a distance of 36 mm, the decrease in conduction velocity of the A‐beta was 1.40 m/s per min, of the A‐delta, 0.43 m/s per min, and of the C‐fibers, 0.023 m/s per min. Thus, recorded at this conduction distance, the A‐delta would disappear in 20 min; the C‐component, in 36 min; and the A‐beta component, in 42 min. These findings indicate that when decremental conduction occurs in a mammalian peripheral nerve exposed to these solutions, the decrement is most apparent in the A‐delta component, then the C‐fiber component, and finally the A‐beta component in the nerve. Similar observations were obtained in nerves exposed to 0.5% NaCl solution except that the rate of decrement was slower.

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Temporospatial effects on orthodromic sensory potential propagation during ischemia

Nielsen

Kardel

1981

Annals of Neurology

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Sensory potentials recorded at two to four sites along the median nerve during ischemia in normal subjects were analyzed with respect to the effects of conduction distance and duration of ischemia. Latency increased rectilinearly with the squared duration of ischemia in minutes, and the rate of the latency increase along the nerve was a power of the preischemic latency, a measure of conduction distance. This finding indicates a temporospatial slowing of sensory conduction velocity of ischemic nerves. Calculated latencies fitted with measured values within +/- 0.2 msec in 95% of 385 recordings. The compound potential amplitude decreased exponentially with the concomitant increase in temporal dispersion, which was the major cause for the decrease in amplitude during the first 20 minutes of ischemia. The nerve conduction pattern during ischemia may serve as a model for biochemical axon membrane dysfunction, a possible factor in the pathogenesis of toxic-metabolic neuropathies.

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The Peripheral Nerve Function in Chronic Renal Failure

Cited by 26 publications

References 7 publications

Neural Drive Impairment in Chronic Kidney Disease Patients Is Associated with Neuromuscular Fatigability and Fatigue

Neural Drive Impairment in Chronic Kidney Disease Patients Is Associated with Neuromuscular Fatigability and Fatigue

Decremental conduction in a mammalian peripheral nerve

Temporospatial effects on orthodromic sensory potential propagation during ischemia

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