The Peripheral Analgesic Effect of Tramadol in Reducing Propofol Injection Pain

Pang, Wei‐Wu; Huang, Pok-Yan; Chang, Da-Peng; Huang, Min-Ho

doi:10.1097/00115550-199924030-00012

Cited by 11 publications

(2 citation statements)

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“…It was noted that tramadol demonstrated a loss of sensation similar to lidocaine ( 21 ). Based on these findings, the authors conducted a new trial on 105 patients, comparing the effect of intravenous injection of 50 mg tramadol, 60 mg lidocaine, and normal saline, given as 1 minute venous retention ( 22 ). The authors reported that tramadol and lidocaine reduced propofol injection pain.…”

Section: Discussionmentioning

confidence: 99%

“…A study evaluated the effect of the topical application of morphine to the de-sheathed saphenous nerve, and reported that the drug reversibly inhibited nerve conduction( 20 ). The local anesthetic effect of tramadol was evaluated by Pang et al ( 21 , 22 ) by administering intradermal injections of 0.5 mL of tramadol, lidocaine, and saline on the volar surfaces of the forearms. The authors reported that both lidocaine and tramadol significantly reduce pain perception compared with saline and there were no significant differences between the two test solutions ( 21 ).…”

Section: Introductionmentioning

confidence: 99%

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Effect of Intraligamentary Tramadol Hydrochloride on Anesthetic Success During Endodontic Management of Mandibular Molars: A Randomized Clinical Controlled Trial

AGGARWAL

2024

Eur Endod J

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Objective Tramadol hydrochloride has shown local anesthetic properties similar to lidocaine, apart from a central analgesic effect. The present study evaluated the effect of the administration of tramadol alone or in addition to 2% lidocaine, as supplementary intraligamentary injections. Methods One hundred and five patients, with a failed primary inferior alveolar nerve block (IANB), were randomly allocated to one of the three supplementary intraligamentary groups: 2% lidocaine with 1:80,000 epinephrine; tramadol hydrochloride (50 mg/mL); and 2% lidocaine with 1:80,000 epinephrine plus tramadol hydrochloride. Patients received 1.2 mL doses (0.6 mL of each root). Patients reporting pain ≤54 on Heft Parker visual analogue scale (Heft-Parker VAS), were categorized as successful anesthesia. A finger pulse oximeter was used to measure the heart rates. The anesthetic success rates, gender, and type of tooth were compared using the Pearson chi-square test. The heart rates and age were statistically evaluated using the one-way analysis of variance test. The level of significance was set at 0.05 (p=0.05). Results The initial IANB was successful in 31% of cases. There were significant differences in the anesthetic success rates of different supplementary intraligamentary injections (χ 2 = 33.6, p<0.001, df=2). The 2% lidocaine-plus-tramadol resulted in significantly higher success rates than the two groups. There were no significant changes in the baseline heart rates of all groups (p>0.05). Conclusion The addition of tramadol to 2% lidocaine with 1:80,000 epinephrine, given as supplementary intraligamentary injection, can help in achieving successful anesthesia during the endodontic management of mandibular molars with irreversible pulpitis resistant to IANB injections.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Intraligamentary Tramadol Hydrochloride on Anesthetic Success During Endodontic Management of Mandibular Molars: A Randomized Clinical Controlled Trial

AGGARWAL

2024

Eur Endod J

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Comparison of Intravenous Lignocaine and Dexmedetomidine for Prevention of Propofol Injection Pain

Singh¹,

Singam²

2021

jemds

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BACKGROUND This study was conducted to compare and evaluate the efficacy and safety of prior intravenous dexmedetomidine with intravenous lignocaine as pre-treatment for prevention of propofol injection pain. METHODS In this prospective, randomised and double blinded clinical study, a total of 200 patients aged between 18 and 70 years of American Society of Anaesthesiologists (ASA) grade I or II posted for elective surgery under general anaesthesia utilising propofol as the inducing agent, were randomly allocated into two groups of 100 patients each, using computer generated random number tables. Group I received intravenous lignocaine 0.2 mg / Kg and group II received intravenous dexmedetomidine 0.5 mcg / Kg respectively prior to administration of propofol (2 mg / Kg) for induction during general anaesthesia. Pain during propofol administration was assessed for each patient using the McCririck and Hunter scale. Peri-operative haemodynamic changes and side effects were noted. Data was analysed using chi-square test and a P-value < 0.05 was considered to be statistically significant. RESULTS A total of 200 patients (100 patients in lignocaine group and 100 patients in dexmedetomidine group) were studied. Statistically significant (P < 0.05) diminution in pain score was discovered to be higher in group II (dexmedetomidine) as compared to group I (lignocaine). 80 % in the dexmedetomidine group had no pain compared to 62 % of the patients in the lignocaine group which is statistically significant. Dexmedetomidine also had a more remarkable effect on the heart rate (10 minutes after intubation) compared to lignocaine, with P = 0.054 which is statistically significant. CONCLUSIONS Intravenous dexmedetomidine is a superior pre-medication compared to intravenous lignocaine in the prevention of pain following propofol administration. It also has additional properties of sedation, analgesia, anxiolysis and sympatholytic action making it a better alternative for the anaesthesiologist and the patient. KEY WORDS Analgesia, Anxiolysis, Pre-Treatment, General Anaesthesia, Sedation, Sympatholytic Action

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A Comparative Study of the Analgesic Effect of Lignocaine and Tramadol in Ameliorating Propofol Injection Pain

Mantha¹,

Chintalapudi²,

Vinnakota³

et al. 2019

jebmh

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BACKGROUNDPropofol is an ideal intravenous anaesthetic agent which provides smooth induction and recovery, but its adverse effect is considerable pain on injection of unknown cause. Various drugs like lignocaine, tramadol, ketorolac, opioids, metoclopramide can be co-administered to alleviate pain. The purpose of this study is to compare the analgesic effect of lignocaine and tramadol in ameliorating propofol injection pain. MATERIALS AND METHODSIn this prospective placebo controlled double blinded study, one hundred and fifty patients under general anaesthesia with propofol as inducing agent of ASA grade 1 and grade 2, were randomly allocated into three groups (A, B, C). In all cases, the drugs were administered slowly one minute prior to the injection of propofol and pain scores were measured immediately. Verbal responses for pain were also recorded. RESULTSResults were analysed by Z-test. p value <0.05 was considered to be significant. Incidence of pain was 16% in Group A, 26% in Group B and 86% in Group C. The difference in the incidence of pain in Group A (lignocaine group) and in Group B (Tramadol Group) was not statistically significant (p Value >0.05). However, both the drugs effectively reduced the incidence of pain on propofol injection when compared to placebo group. (p value <0.05), by Z test (Z>1.96). CONCLUSIONThere is no statistically significant difference between lignocaine and tramadol with regard to their efficacy in reducing propofol injection pain. Both the drugs (Lignocaine 60 mg and Tramadol 50 mg), can be given one minute prior to the propofol injection and they could prevent the pain of propofol injection in patients undergoing general anaesthesia, as compared to the placebo group.

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The Peripheral Analgesic Effect of Tramadol in Reducing Propofol Injection Pain

Cited by 11 publications

References 0 publications

Effect of Intraligamentary Tramadol Hydrochloride on Anesthetic Success During Endodontic Management of Mandibular Molars: A Randomized Clinical Controlled Trial

Effect of Intraligamentary Tramadol Hydrochloride on Anesthetic Success During Endodontic Management of Mandibular Molars: A Randomized Clinical Controlled Trial

Comparison of Intravenous Lignocaine and Dexmedetomidine for Prevention of Propofol Injection Pain

A Comparative Study of the Analgesic Effect of Lignocaine and Tramadol in Ameliorating Propofol Injection Pain

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