The periosteal microcirculation in health and disease: An update on clinical significance

Szabó, Andrea; Janovszky, Ágnes; Pócs, Levente; Boros, Mihály

doi:10.1016/j.mvr.2016.11.005

Cited by 14 publications

(8 citation statements)

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“…Since sex (female) was also a significant risk factor for complications, older women should be particularly monitored for complications after maxillofacial fracture surgery. Furthermore, hormone replacement therapy may decrease the incidence rate of complications in younger women with maxillofacial fractures [23]. Next, a significant difference was observed in diagnosis (midfacial fracture/trauma or Le Fort I osteotomy), which may be attributed to the fact that the most common complication, plate exposure, occurred in the Infrazygomatic crest of the Le Fort I osteotomy.…”

Section: Discussionmentioning

confidence: 98%

Complications of Poly-l-Lactic Acid and Polyglycolic Acid (PLLA/PGA) Osteosynthesis Systems for Maxillofacial Surgery: A Retrospective Clinical Investigation

et al. 2021

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Two second-generation PLLA/PGA bioresorbable osteosynthetic plate systems for oral and maxillofacial surgery are available in Japan. The two systems have different PLLA-PGA component ratios (RapidSorb®, 85:15; Lactosorb®, 82:18) and plate and screw shapes. We conducted a retrospective study to compare our clinical evaluation and examine the incidence of postoperative complications between the two plate systems. A retrospective survey was conducted in 148 patients (midfacial fracture/trauma (68.2%) and dentofacial deformity patients (31.8%); males (54.7%); median age, 37.5 years) treated using maxillofacial osteosynthetic plate systems. The complications included plate exposure (7.4%), infection, (2.7%), and plate breakage (0.7%). Multivariate logistic regression analysis showed a significant correlation between sex (female), plate system (Lactosorb®), number of plates, and pyriform aperture and periorbital sites of plate placement (p < 0.05). Additionally, the propensity score-adjusted model showed a significant correlation between Lactosorb® and postoperative complications (odds ratio 1.007 (95% confidence interval, 1.001–1.055), p < 0.01). However, the two plate systems showed a low incidence rate of complications, and the plate integration and survivability were similar using 2.0-mm or 1.5-mm resorbable plate regardless of the plate system. Our findings suggest that female sex and a greater number of plates are risk factors for postoperative complications, whereas pyriform aperture and periorbital plate placements reduce the risk.

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Section: Discussionmentioning

confidence: 98%

Complications of Poly-l-Lactic Acid and Polyglycolic Acid (PLLA/PGA) Osteosynthesis Systems for Maxillofacial Surgery: A Retrospective Clinical Investigation

et al. 2021

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“…In contrast, such as estrogen, calcitonin, and bisphosphonates all have positive effects on the maintenance of intraosseous vascularity [34][35][36] . Therefore, exploring more therapeutic strategies that can improve intraosseous microcirculation to treat of osteoporosis are crucial for clinical applications [37] . This experiment veri ed that the bone repair of MSCs in the animal model of osteoporosis is related to the role of promoting blood vessels.…”

Section: Discussionmentioning

confidence: 99%

Mesenchymal Stem Cells Prevent Ovariectomy-Induced Osteoporosis Formation in Mice by Intraosseous Vascular Remodeling

Wang

Tang

et al. 2021

Preprint

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BackgroundPostmenopausal osteoporosis is the most common type of primary osteoporosis that is characterized by a decrease in bone mass and an increase risk of fractures. Mesenchymal stem cells (MSCs) can promote osteogenesis and are a promising therapy for postmenopausal osteoporosis. The aim of this study was to clarify the relationship between improved intraosseous microcirculation and increased bone mass by MSCs in postmenopausal osteoporosis.MethodsWe isolated primary MSCs and characterized their cellular properties. Bone volume and morphological analyses of mouse femurs were performed by transplanting the cells into post-ovariectomized mice via tail vein. Femoral artery ligation was performed on mice. By Laser Speckle flowmetry, vascular perfusion and femoral trabecular bone and cortical bone analysis, we determined the effects of MSCs in promoting intraosseous angiogenesis and preventing osteoporosis in mice. ResultsMSCs transplantation enhanced trabecular number, trabecular bone volume / total volume, and trabecular bone mineral density in ovariectomized mice. Reduced intraosseous blood flow due to hindlimb ischemia can lead to accelerated bone loss. In contrast, MSCs promoted the reconstruction of intraosseous microcirculation and reduced bone loss.ConclusionsMSCs could effectively prevent postmenopausal osteoporosis formation, which is associated with the involvement of MSCs in the reestablishment of microcirculation within the skeleton. This study has revealed the potential role of MSCs in the treatment of postmenopausal osteoporosis and lays the foundation for clinical application studies.

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“…При переломе микроциркуляторная активность резко снижается, что приводит к выраженной гипоксии местных тканей [5]. Интенсивность посттравматической регенерации костной ткани зависит от многих факторов, но одним из ведущих является восстановление микроциркуляции в зоне перелома [6]. I. Macnab и W. G. Dehoas в 1974 г. доказали, что восстановление пери-и эндостальной микроциркуляции способствует заживлению перелома [7].…”

Section: обоснованиеunclassified

Closed Fractures of the Distal Part of the Shin Bones. Different Types and Methods of the Treatment in Adolescence. Short Period Results

Dorokhin

Иванович²,

Крупаткин

et al. 2021

Physical and rehabilitation medicine, medical rehabilitation

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Background.Fractures of the distal leg bones in children, due to the peculiarities of localization, the presence of a growth zone, the proximity of the joint and the involvement of the ligamentous apparatus in the pathological process, present a difficult problem in the choice of treatment and rehabilitation.Aims:In order to our aims we create the diagnostic and treatment algorithm in the system of early rehabilitation after fractures in the distal part of the shin bone in adolescence.Methods.Our clinical investigation based on the treatment of 56 patients in the age 817 years. Cohort of patients consist from three age groups: 811 years (n=13), 1214 years (n=28) and 1517 years (n=15). Examination was done with X-rays, CT and Ultrasound, specialy in the cases where the damage of ligamentous apparatus was suspicious. The main method of treatment was surgical osteosynthesis by pins, plates and screws. In the rehabilitation period the legs were immobilized by Plaster of Paris for 46 weeks.Results.In majority of cases the outcomes in the period of 68 weeks after trauma were good and satisfactory. The method of laser Doppler fluometry was performed in 16 cases in follow up period after trauma for examination of the regional blood circulation as a argumentation of regeneration process.Conclusion.The different choice in treatment of compound fractures of the distal part of the shin bones according to morphological changes in adolescence permits to aid good results in majority of caces.

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The periosteal microcirculation in health and disease: An update on clinical significance

Cited by 14 publications

References 100 publications

Complications of Poly-l-Lactic Acid and Polyglycolic Acid (PLLA/PGA) Osteosynthesis Systems for Maxillofacial Surgery: A Retrospective Clinical Investigation

Complications of Poly-l-Lactic Acid and Polyglycolic Acid (PLLA/PGA) Osteosynthesis Systems for Maxillofacial Surgery: A Retrospective Clinical Investigation

Mesenchymal Stem Cells Prevent Ovariectomy-Induced Osteoporosis Formation in Mice by Intraosseous Vascular Remodeling

Closed Fractures of the Distal Part of the Shin Bones. Different Types and Methods of the Treatment in Adolescence. Short Period Results

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