The perineuronal net component of the extracellular matrix in plasticity and epilepsy

McRae, Paulette A.; Porter, Brenda E.

doi:10.1016/j.neuint.2012.08.007

Cited by 122 publications

(130 citation statements)

References 140 publications

(210 reference statements)

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“…The reduction in PNN numbers and partial loss of PC terminals in sedentary mutants well fits with the PNN attenuation found both in models of PC denervation (Foscarin et al, 2011;Carulli et al, 2013) and in developmental and adult models of reduced GABAergic activity (Harauzov et al, 2010;McRae et al, 2012;Blosa et al, 2016). On the contrary, increased PNN staining after physical exercise in tbl mice is consistent with a better survival and functioning of mutant PCs, that led to increased net deposition.…”

Section: Discussionsupporting

confidence: 79%

Preventive motor training but not progenitor grafting ameliorates cerebellar ataxia and deregulated autophagy in tambaleante mice

Fucà

Guglielmotto

Boda

et al. 2017

Neurobiology of Disease

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Authors' contributionEF and KL performed grafts; EF performed motor training, behavioral, immunohistochemical analyses and stereological counts; MG and EB performed molecular biology and biochemical experiments; EF, FR, KL and AB conceived experiments, EF, KL and AB interpreted data and wrote the manuscript; all the authors reviewed and approved the final manuscript. Highlights• Preventive grafts of Purkinje cells survive despite ongoing host neurodegeneration correlates. Our results demonstrate that, despite a good survival rate and integration of grafted PCs, the adopted grafting protocol could not alleviate the ataxic symptoms in tbl mice. Conversely, preventive motor training increases PCs survival with a moderate positive impact on the motor phenotype.

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Section: Discussionsupporting

confidence: 79%

Preventive motor training but not progenitor grafting ameliorates cerebellar ataxia and deregulated autophagy in tambaleante mice

Fucà

Guglielmotto

Boda

et al. 2017

Neurobiology of Disease

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“…As it is thought that PNNs stabilize synaptic connectivity, it has been suggested that areas with high PNN levels may be less plastic (Gati et al 2010;Bartus et al 2012;McRae and Porter 2012). We observed that the CA3 subfield of the hippocampus had the greatest amount of WFA staining, with less intense staining observed in other hippocampal subfields, particularly CA1.…”

Section: Discussionmentioning

confidence: 52%

Disruption of the perineuronal net in the hippocampus or medial prefrontal cortex impairs fear conditioning

et al. 2013

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The perineuronal net (PNN) surrounds neurons in the central nervous system and is thought to regulate developmental plasticity. A few studies have shown an involvement of the PNN in hippocampal plasticity and memory storage in adult animals. In addition to the hippocampus, plasticity in the medial prefrontal cortex (mPFC) has been demonstrated to be critical for the storage of long-term memory, particularly memories for temporally separated events. In the present study, we examined the role of PNN in the acquisition and retention of memories for trace (in which the conditioned and unconditioned stimuli are temporally separated) and delayed (in which the conditioned and unconditioned stimuli overlap) fear conditioning in both the hippocampus and the mPFC. Consistent with a role for the hippocampus in memory storage in both delayed and trace fear conditioning, removal of hippocampal PNN disrupted contextual and trace fear memory. Disruption of the PNN in the mPFC impaired long-term trace and conditioned stimulus (CS)-elicited fear memory in the trace fear conditioning task. Interestingly, CS-elicited fear memory was also impaired when a delayed fear conditioning paradigm was used. These findings further support a role for the PNN in neural plasticity and implicate PNN-regulated plasticity in neocortical memory storage.

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“…Ankyrin-2 borders the axon initial segment (58) and thus may also contribute to GABAergic synapse development in this specialized domain. Tenascin-R and brevican are major components of the perineuronal net that is prominent around the axon initial segment and around subsets of interneurons (59). Furthermore, tenascin-R Ϫ/Ϫ mice show reduced numbers and altered morphology of perisomatic asymmetric synapses and a corresponding reduction in inhibitory transmission (60,61).…”

Section: Discussionmentioning

confidence: 99%

A Combined Transgenic Proteomic Analysis and Regulated Trafficking of Neuroligin-2

Kang

Cassidy

et al. 2014

Journal of Biological Chemistry

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Background: Brain inhibitory synaptic connections present challenges for molecular identification and imaging. Results: Transgenic mice expressing tagged neuroligin-2 were used to identify associated complexes and image inhibitory synapses in multiple brain regions. Conclusion: Neuroligin-2-associated complexes are enriched in synaptic components, and neuroligin-2 undergoes regulated dynamin-dependent endocytosis and retromer association. Significance: New data and approaches are presented for brain inhibitory synapse proteomics and imaging.

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The perineuronal net component of the extracellular matrix in plasticity and epilepsy

Cited by 122 publications

References 140 publications

Preventive motor training but not progenitor grafting ameliorates cerebellar ataxia and deregulated autophagy in tambaleante mice

Preventive motor training but not progenitor grafting ameliorates cerebellar ataxia and deregulated autophagy in tambaleante mice

Disruption of the perineuronal net in the hippocampus or medial prefrontal cortex impairs fear conditioning

A Combined Transgenic Proteomic Analysis and Regulated Trafficking of Neuroligin-2

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