The Perinatal Condition Around Birth and Cardiovascular Risk Factors in the Japanese General Population: The Suita Study

Abstract

To investigate the relationship between perinatal condition around birth and cardiovascular risk in later life. Methods: Retrospective data were examined from 1241 city dwellers (521 men, 720 women; age 41-69 years) who had undergone medical examination at a single institution including blood tests and physical measurements from 2007 to 2008. The questionnaire was conducted to determine how perinatal factors affect their lives later. We also selected and studied a total of 28 individuals (12 men and 16 women) specifically about the conformity rate of the breastfeeding method between participants' memories and what was written in the maternal and child health handbooks. Results: The conformity rate of the breastfeeding method between a self-questionnaire and his/her maternal and child health handbook was well correlated (r 0.73; p 0.025). Among the data in women who were born at home, HbA1C levels (5.36 0.03 vs. 5.25 0.05 mg/dL, p 0.03) and low-density lipoprotein cholesterol (136.0 1.4 vs. 129.3 2.5 mg/dL, p 0.04) were higher than women who were born at the hospital. Women raised by formula showed higher low-density lipoprotein cholesterol levels than women fed breast milk or a mixture of breast milk and formula (150.2 4.8 vs. 138.7 3.7, 142.5 2.6 mg/dL, p 0.04). Fasting blood glucose levels at an adult time in men and women born through breech presentation were higher than those by the cephalic presentation (123.2 7.8 vs. 106.8 1.2 mg/dL, p 0.03). Conclusion: The study proposed that some perinatal conditions around birth such as delivery place, presenting part, and lactation affected especially Japanese women's cardiovascular risks between ages 41 and 69 years. cular diseases in adulthood include during the periconceptional, fetal, and infant phases of life. Research in evolutionary biology, developmental biology, and animal and human physiology has provided support for this idea 2, 3). Initially, genetic factors may mostly influence fetal development and growth. However, when development is inhibited by maternal constraint (physics, size of the pelvis, nutritional status, primiparous, placental function) a PARs (predictive adaptive Copyright©2019 Japan Atherosclerosis Society This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.

Associations of Infant Feeding with Body Composition and Cardiometabolic Health in Young Female University Students

“…We found two studies from developed Asian countries. 16 , 17 Consistent with our observation, Japanese middle-aged women fed formula milk, but not men, experienced higher LDL cholesterol levels than women fed breast milk or a mixture of breast and formula milk. 17 Hui et al reported that exclusive breastfeeding, but not mixed feeding at 0 to 3 months, compared with formula feeding was associated with lower total and LDL cholesterol at 17.5 years in 3261 participants in the Hong Kong Chinese birth cohort Children of 1997.…”

“… 14 , 15 These were based largely on observational studies, which were carried out in mostly high-income countries from western world, and studies from developed Asian countries are limited. 16 , 17 Because some studies suggested a stronger effect in women, 9 , 17 , 18 the present study tested whether infant feeding was associated with body composition and cardiometabolic health, including lipid profile and a marker of autonomic nervous function in young Japanese female university students of Mukogawa Women's University, in whom the socioeconomic status was less heterogenous. 19 …”

Physique at Birth and Cardiovascular Disease Risk Factors in Japanese Urban Residents: the KOBE Study

“…Unfortunately, in the present study, the research team was unable to investigate this topic. Fourthly, although it has been reported that perinatal status correlates with risk factors for future lifestyle-related diseases 55) , the research team was also unable to investigate this correlation and therefore hopes to examine this topic in the future.…”