The perimenopausal woman: Endocrinology and management

Hale, Georgina E.; Robertson, David; Burger, Henry G.

doi:10.1016/j.jsbmb.2013.08.015

Cited by 102 publications

(65 citation statements)

References 114 publications

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“…(1) Of menopausal women, 60%-80% have vegetovascular, mental and metabolic disorders. One of the main signs of neurovegetative changes in climacteric women is the presence of sleep disorders (SDs).…”

Section: Introductionmentioning

confidence: 99%

Circadian Rhythms of Melatonin Secretion in Peri- and Postmenopausal Women with Insomnia

Мадаева¹,

Semenova²,

Solodova³

et al. 2017

IJBM

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The aim of this study was to assess complaints about sleep quality and to investigate circadian rhythms of melatonin secretion in peri-and postmenopausal women.Material and Methods: A total of 146 climacteric women were examined. All patients were divided into 2 groups: Group1 included 72 perimenopausal women and Group 2 included 74 postmenopausal women. Women were surveyed with special questionnaires: PSQI, FFS, ESS, Daytime Feeling and Functioning Scale. Insomnia Severity Index (ISI) was calculated. Salivary melatonin content was determined (4 times a day) by immunoassay using Microplate Reader EL×808 (USA).Results: Perimenopausal women often complained about difficulties falling asleep (more than 20 minutes from the moment the light was turned off) and difficulties awakening in the morning, while postmenopausal women often complained about snoring and frequent awakenings during sleep (≥2 times). ISI was 21.3±0.54 in Group 1 and 24.8±0.31 in Group 2, which corresponded to insomnia. Daily melatonin secretion in perimenopausal patients with insomnia was altered -the maximal level was registered in the morning hours. The circadian rhythms of melatonin secretion in the group of postmenopausal women did not correlate to the occurrence of insomnia. Conclusion:We can recommend administration of melatonin in the evening time and light therapy in the early morning hours in the complex treatment of sleep disprders in perimenopausal women for normalizing and shifting the chronobiological rhythms of melatonin secretion, and specific therapy is aimed to eliminate snoring for postmenopausal women.

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Section: Introductionmentioning

confidence: 99%

Circadian Rhythms of Melatonin Secretion in Peri- and Postmenopausal Women with Insomnia

Мадаева¹,

Semenova²,

Solodova³

et al. 2017

IJBM

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“…The review did not include intervention studies, neuroendocrine studies, animal models, or studies of postmenopausal women. These domains are clearly important for understanding the development of depression around menopause but are beyond the range of this review and are examined elsewhere [14,[21][22][23][24][25][26][27][28][29].…”

Section: Introductionmentioning

confidence: 99%

Depression in the menopause transition: risks in the changing hormone milieu as observed in the general population

Freeman

2015

womens midlife health

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There is accumulating evidence but no definitive answers about the incidence of depressed mood in the menopause transition and its association with the changing hormonal milieu. While a changing hormonal milieu is the natural condition for all women, only a minority of mid-life women experience debilitating depressive symptoms or clinical depression. This review focuses on associations between depressed mood and the menopause transition, primarily as identified in longitudinal, population-based studies in the past decade. Further aims were to present reported associations between depressed mood and reproductive hormones in the menopause transition as evaluated in the general population and associations of depressive symptoms or clinical depression with menopausal hot flashes or poor sleep in perimenopausal women. There is evidence to support the role of the changing endocrine milieu in the development of depressed mood in the menopause transition, but the contribution of hormones as measured is small. Disentangling the numerous factors that are associated with depression in midlife women is a major challenge for research and for clinical care, where treatments are needed to improve the most distressing menopausal symptoms.

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“…In the Seattle Woman's Midlife Health study, the most common subjective menstrual cycle changes were flow-related and included a heavier menstrual flow in 29% and a longer duration of the flow in 20% [14]. Menstrual blood loss was greater following ovulatory rather than anovulatory cycles [15], especially if the ovulatory cycle followed a prolonged interval of anovulation, during which unopposed high estradiol levels contributed to abnormal excessive proliferative changes in the endometrium [16].…”

Section: Menstrual Cycle During Menopausal Transitionmentioning

confidence: 99%

Reproductive Aging: Perimenopause and Psychopathological Symptoms

Geršak¹,

Gersak²,

Turčin³

2018

Sex Hormones in Neurodegenerative Processes and Diseases

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The female reproductive axis essentially comprises of the hypothalamic-pituitaryovarian axis and the mullerian-derived structures. The reproductive axis ages to a nonfunctional state (menopause) much earlier than the other organ systems do, at a time when a woman is otherwise healthy. The basis of reproductive senescence in women is oocyte depletion in the ovary. Perimenopause is defined by menstrual cycle and endocrine changes, such as disturbed ovarian-pituitary-hypothalamic feedback relationships, inaccurate estrogen levels, and decreased progesterone levels. Many psychopathological changes can take place, but most commonly women experience mild cognitive impairment, anxiety, irritability, mood swings, and depression. Estrogens influence depression and depressive-like behavior through interactions with neurotropic factors and through an influence on the serotonergic system.

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The perimenopausal woman: Endocrinology and management

Cited by 102 publications

References 114 publications

Circadian Rhythms of Melatonin Secretion in Peri- and Postmenopausal Women with Insomnia

Circadian Rhythms of Melatonin Secretion in Peri- and Postmenopausal Women with Insomnia

Depression in the menopause transition: risks in the changing hormone milieu as observed in the general population

Reproductive Aging: Perimenopause and Psychopathological Symptoms

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