“…Studies indicate that dehydration is a possible cause for punctuate corneal staining [27] and scleral impression. Lens dehydration also is related to wearer discomfort [28,29] and to dry-eye symptoms [30]. The large variety of recipes for contact-lens materials, the difficult control of in vivo conditions, and the interplay of numerous other factors (e.g., environmental conditions, lens geometry, material properties, closed-eye or open-eye wear, intersubject variability) make a comprehensive, conclusive, in vivo experimental study of SCL dehydration difficult.…”