The Performance of CO<sub>2</sub> Laser Photoacoustic Spectrometer In Concentration Acetone Detection As Biomarker For Diabetes Mellitus Type 2

Tyas, F H; Nikita, Jeilen Gabriela; Apriyanto, Donni Kis; Mitrayana, -; Amin, Mochamad Nurul

doi:10.1088/1742-6596/1011/1/012056

Cited by 12 publications

(8 citation statements)

References 3 publications

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“…A group of healthy individuals was studied against a group of patients with type 2 diabetes mellitus (DM). In the group with type 2 DM, the acetone range was to vary between 101 and 162 ppb, while in healthy individuals, the acetone range was between 15 and 85 ppb [112].…”

Section: Ethylene (C 2 H 4 )mentioning

confidence: 93%

Advances in Mid-Infrared Spectroscopy-Based Sensing Techniques for Exhaled Breath Diagnostics

et al. 2020

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Human exhaled breath consists of more than 3000 volatile organic compounds, many of which are relevant biomarkers for various diseases. Although gas chromatography has been the gold standard for volatile organic compound (VOC) detection in exhaled breath, recent developments in mid-infrared (MIR) laser spectroscopy have led to the promise of compact point-of-care (POC) optical instruments enabling even single breath diagnostics. In this review, we discuss the evolution of MIR sensing technologies with a special focus on photoacoustic spectroscopy, and its application in exhaled breath biomarker detection. While mid-infrared point-of-care instrumentation promises high sensitivity and inherent molecular selectivity, the lack of standardization of the various techniques has to be overcome for translating these techniques into more widespread real-time clinical use.

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Section: Ethylene (C 2 H 4 )mentioning

confidence: 93%

Advances in Mid-Infrared Spectroscopy-Based Sensing Techniques for Exhaled Breath Diagnostics

et al. 2020

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“…As a representative example, although many tumor-targeting sonophores can enhance the intratumoral PA signal level over that in control images, usually a single sonophore has been used to target one specific malignant cell among multiple heterogeneous cells in a tumor. Ideally, as shown from many spectroscopic PAI studies, multiple cells could be resolved simultaneously by using spectral unmixing, which would facilitate accurate classification of tumor subtypes and lead to more effective intervention. ,, Diabetes mellitus (DM) is another infamous disease for which PA detection is being investigated, making use of the spectral signature of glucose or detecting abnormal tissue formations near the skin. ,,,,− These approaches are aimed at detecting DM-related symptoms, rather than identifying the cause of the disease, such as pancreatic cell dysfunction.…”

Section: Challenge 3: Targeted Deliverymentioning

confidence: 99%

Recent Advances in Contrast-Enhanced Photoacoustic Imaging: Overcoming the Physical and Practical Challenges

et al. 2023

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For decades now, photoacoustic imaging (PAI) has been investigated to realize its potential as a niche biomedical imaging modality. Despite its highly desirable optical contrast and ultrasonic spatiotemporal resolution, PAI is challenged by such physical limitations as a low signal-to-noise ratio (SNR), diminished image contrast due to strong optical attenuation, and a lower-bound on spatial resolution in deep tissue. In addition, contrast-enhanced PAI has faced practical limitations such as insufficient cell-specific targeting due to low delivery efficiency and difficulties in developing clinically translatable agents. Identifying these limitations is essential to the continuing expansion of the field, and substantial advances in developing contrast-enhancing agents, complemented by high-performance image acquisition systems, have synergistically dealt with the challenges of conventional PAI. This review covers the past four years of research on pushing the physical and practical challenges of PAI in terms of SNR/contrast, spatial resolution, targeted delivery, and clinical application. Promising strategies for dealing with each challenge are reviewed in detail, and future research directions for next generation contrast-enhanced PAI are discussed.

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“…In recent years, the technique of PAS has been demonstrated for non-invasive glucose detection due to the higher sensitivity and selectivity [175,176]. Tyas et al measured breath acetone on subjects with T2DM and a group of healthy volunteers, using a CO 2 laser PA spectrometer [177]. In this research, the highest observed intracavity power was (49.96 ± 0.02) W for active medium gas composition He: N 2 : CO 2 at 30:50:50 and the acetone concentrations was measured on 10P20 laser line, and the lowest detection limit set at (30 ± 4) ppb.…”

Section: Lpas In Diabetesmentioning

confidence: 99%

Applications of Near Infrared Photoacoustic Spectroscopy for Analysis of Human Respiration: A Review

et al. 2020

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In this review, applications of near-infrared photoacoustic spectroscopy are presented as an opportunity to evaluate human respiration because the measurement of breath is fast, intact and simple to implement. Recently, analytical methods for measuring biomarkers in exhaled air have been extensively developed. With laser-based photoacoustic spectroscopy, volatile organic compounds can be identified with high sensitivity, at a high rate, and with very good selectivity. The literature review has shown the applicability of near-infrared photoacoustic spectroscopy to one of the problems of the real world, i.e., human health. In addition, the review will consider and explore different breath sampling methods for human respiration analysis.

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The Performance of CO₂ Laser Photoacoustic Spectrometer In Concentration Acetone Detection As Biomarker For Diabetes Mellitus Type 2

Cited by 12 publications

References 3 publications

Advances in Mid-Infrared Spectroscopy-Based Sensing Techniques for Exhaled Breath Diagnostics

Advances in Mid-Infrared Spectroscopy-Based Sensing Techniques for Exhaled Breath Diagnostics

Recent Advances in Contrast-Enhanced Photoacoustic Imaging: Overcoming the Physical and Practical Challenges

Applications of Near Infrared Photoacoustic Spectroscopy for Analysis of Human Respiration: A Review

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The Performance of CO2 Laser Photoacoustic Spectrometer In Concentration Acetone Detection As Biomarker For Diabetes Mellitus Type 2

Cited by 12 publications

References 3 publications

Advances in Mid-Infrared Spectroscopy-Based Sensing Techniques for Exhaled Breath Diagnostics

Advances in Mid-Infrared Spectroscopy-Based Sensing Techniques for Exhaled Breath Diagnostics

Recent Advances in Contrast-Enhanced Photoacoustic Imaging: Overcoming the Physical and Practical Challenges

Applications of Near Infrared Photoacoustic Spectroscopy for Analysis of Human Respiration: A Review

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The Performance of CO₂ Laser Photoacoustic Spectrometer In Concentration Acetone Detection As Biomarker For Diabetes Mellitus Type 2