The performance of BMP-2 loaded TCP/HAP porous ceramics with a polyelectrolyte multilayer film coating

Crouzier, Thomas; Sailhan, Frédéric; Becquart, Pierre; Guillot, Raphaël; Logeart-Avramoglou, Delphine; Picart, Catherine

doi:10.1016/j.biomaterials.2011.06.062

Cited by 130 publications

(131 citation statements)

References 55 publications

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“…β-TCP has been widely used in surgical procedures because of its degradation behavior and similar calcium/ phosphorus (Ca/P) ratio to hydroxyapatite, 25,26 which is considered the modified form of up to 50% by volume and 70% by weight of human bone. 27 However, significant disadvantages have been observed.…”

Section: Discussionmentioning

confidence: 99%

Bioabsorbable self-retaining PLA/nano-sized β-TCP cervical spine interbody fusion cage in goat models: an in vivo study

Cao¹,

Chen²,

Jiang³

et al. 2017

IJN

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Study design This is an experimental animal study. Objective The objective of this study was to compare an anterior cervical discectomy and interbody fusion of a novel polylactide/nano-sized β-tricalcium phosphate (PLA/nβ-TCP) bioabsorbable self-retaining cervical fusion cage (BCFC) with an autologous bone graft and polyetheretherketone (PEEK) cages. Background Although PLA cervical cages have potential advantages compared with traditional materials, they are not currently routinely used in spine surgery because of undesirable effects such as the lack of osteoconductivity and osteolysis around the implant. This study involved the manufacturing of a bioabsorbable cage from PLA/nβ-TCP that was then used as a device for anterior cervical discectomy and fusion (ACDF) on a goat cervical spine fusion model. Materials and methods Eighteen goats underwent C3/C4 discectomy and were randomly divided into three groups based on the following methods: Group A (n=6), an autologous bone graft; Group B (n=6), PEEK cage filled with an autologous graft; and Group C (n=6), BCFC filled with an autologous iliac bone. Radiography was performed preoperatively and postoperatively and at 1, 4, 8, and 12 weeks after the operation. Disc space height (DSH) was measured at the same time. After 12 weeks, the fused segments were harvested and evaluated with functional radiographic views, biomechanical testing, and histological analyses. Results Over a 12-week period, the BCFC and PEEK cage groups exhibited significantly higher DSH values than the bone graft group. Additionally, the BCFC group yielded a significantly lower range of motion in axial rotation than both the autologous bone graft and PEEK cage groups. A histologic evaluation revealed an increased intervertebral bone volume/total volume ratio and better interbody fusion in the BCFC group than in the other groups. Conclusion The BCFC device exhibited better results than the autologous bone graft and PEEK cages in single-level ACDF models in vivo. This device may be a potential alternative to the current PEEK cages.

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Section: Discussionmentioning

confidence: 99%

Bioabsorbable self-retaining PLA/nano-sized β-TCP cervical spine interbody fusion cage in goat models: an in vivo study

Cao¹,

Chen²,

Jiang³

et al. 2017

IJN

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“…Despite satisfactory initial results, long-term problems, such as subsidence and breakage of the cage, have been noticed. 8,9 The development of bioabsorbable materials 10,11 and inherent limitations of current nonabsorbable CSIFC devices have promoted the study of bioabsorbable cages. Bioabsorbable cages can be designed with similar stiffness to human bone to reduce stress shielding of the inside graft, and adequate postoperative assessment of interbody fusion would be possible.…”

Section: Introductionmentioning

confidence: 99%

Biomechanical stability of a bioabsorbable self-retaining polylactic acid/nano-sized β-tricalcium phosphate cervical spine interbody fusion device in single-level anterior cervical discectomy and fusion sheep models

Cao¹,

Duan²,

Li³

et al. 2012

IJN

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Purpose:The aim of this study was to investigate the biomechanical stability provided by a novel, polylactic acid/nano-sized, β-tricalcium phosphate, bioabsorbable, self-retaining cervical fusion cage (BCFC). Methods: Quasistatic nonconstraining torques (maximum 1.5 NM) induced flexion, extension, lateral bending (±1.5 NM), and axial rotation (±1.5 NM) on 32 sheep cervical spines (C2-C5). The motion segment C3-C4 was first tested intact; the following groups were tested after complete discectomy: autologous tricortical iliac crest bone graft, Medtronic-Wego polyetheretherketone (PEEK) cage, Solis PEEK cage, and BCFC. The autologous bone graft group was tested with an anterior plate. The mean range of motion (ROM) was calculated from the load-displacement curves. Results: BCFC significantly decreased ROM in lateral bending and axial rotation compared to other implants, and no significant difference in ROM between two types of PEEK cages and BCFC could be observed in flexion and extension. Anterior cervical plate (ACP) significantly decreased ROM in flexion and extension, but no significant difference in ROM between BCFC and bone graft plus ACP could be determined in lateral bending and axial rotation. Conclusion: The BCFC device showed better stability to autologous tricortical iliac crest bone graft and PEEK cages in single-level anterior cervical discectomy and fusion models and thus may be a potential alternative to the current PEEK cages.

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“…22 ALP activity has been used as an early marker for functionality and differentiation of osteoblasts during in vitro experiments. 23 In this study, ALP activity of hMSCs on the MCS-15/rhBMP-2 was significantly higher than that on MCS-4/rhBMP-2 system at 7 days, as shown in Figure 12, indicating that the cells differentiated more quickly after being cultured on the MCS-15/rhBMP-2 system than on the MCS-4/rhBMP-2 system. This increased ALP activity probably resulted from a larger quantity of rhBMP-2 released in a sustainable manner from MCS-15 as compared with MCS-4.…”

mentioning

confidence: 47%

Mesoporous calcium–silicon xerogels with mesopore size and pore volume influence hMSC behaviors by load and sustained release of rhBMP-2

Song

Qian

et al. 2015

IJN

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Mesoporous calcium–silicon xerogels with a pore size of 15 nm (MCS-15) and pore volume of 1.43 cm 3 /g were synthesized by using 1,3,5-mesitylene (TMB) as the pore-expanding agent. The MCS-15 exhibited good degradability with the weight loss of 50 wt% after soaking in Tris-HCl solution for 56 days, which was higher than the 30 wt% loss shown by mesoporous calcium–silicon xerogels with a pore size of 4 nm (MCS-4). The pore size and pore volume of MCS-15 had significant influences on load and release of recombinant human bone morphogenetic protein-2 (rhBMP-2). The MCS-15 had a higher capacity to encapsulate a large amount of rhBMP-2; it could adsorb 45 mg/g of rhBMP-2 in phosphate-buffered saline after 24 hours, which was more than twice that with MCS-4 (20 mg/g). Moreover, the MCS-15 system exhibited sustained release of rhBMP-2 as compared with MCS-4 system (showing a burst release). The MCS-15/rhBMP-2 system could promote the proliferation and differentiation of human mesenchymal stem cells, showing good cytocompatibility and bioactivity. The results indicated that MCS-15, with larger mesopore size and higher pore volume, might be a promising carrier for loading and sustained release of rhBMP-2, which could be used as bone repair material with built-in osteoinduction function in bone reconstruction.

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The performance of BMP-2 loaded TCP/HAP porous ceramics with a polyelectrolyte multilayer film coating

Cited by 130 publications

References 55 publications

Bioabsorbable self-retaining PLA/nano-sized β-TCP cervical spine interbody fusion cage in goat models: an in vivo study

Bioabsorbable self-retaining PLA/nano-sized β-TCP cervical spine interbody fusion cage in goat models: an in vivo study

Biomechanical stability of a bioabsorbable self-retaining polylactic acid/nano-sized β-tricalcium phosphate cervical spine interbody fusion device in single-level anterior cervical discectomy and fusion sheep models

Mesoporous calcium–silicon xerogels with mesopore size and pore volume influence hMSC behaviors by load and sustained release of rhBMP-2

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The performance of BMP-2 loaded TCP/HAP porous ceramics with a polyelectrolyte multilayer film coating

Cited by 130 publications

References 55 publications

Bioabsorbable self-retaining PLA/nano-sized &beta;-TCP cervical spine interbody fusion cage in goat models: an in vivo study

Bioabsorbable self-retaining PLA/nano-sized &beta;-TCP cervical spine interbody fusion cage in goat models: an in vivo study

Biomechanical stability of a bioabsorbable self-retaining polylactic acid/nano-sized &beta;-tricalcium phosphate cervical spine interbody fusion device in single-level anterior cervical discectomy and fusion sheep models

Mesoporous calcium&ndash;silicon xerogels with mesopore size and pore volume influence hMSC behaviors by load and sustained release of&nbsp;rhBMP-2

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Bioabsorbable self-retaining PLA/nano-sized β-TCP cervical spine interbody fusion cage in goat models: an in vivo study

Bioabsorbable self-retaining PLA/nano-sized β-TCP cervical spine interbody fusion cage in goat models: an in vivo study

Biomechanical stability of a bioabsorbable self-retaining polylactic acid/nano-sized β-tricalcium phosphate cervical spine interbody fusion device in single-level anterior cervical discectomy and fusion sheep models

Mesoporous calcium–silicon xerogels with mesopore size and pore volume influence hMSC behaviors by load and sustained release of rhBMP-2