The performance evaluation of Eugenol and Linalool microencapsulated by PLA on their activities against pathogenic bacteria

Silva, C.G.; Yudice, Eliana Della Coletta; Campini, Priscila Almeida Lucio; Rosa, Derval dos Santos

doi:10.1016/j.mtchem.2021.100493

Cited by 14 publications

(11 citation statements)

References 43 publications

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“…Such limitations of potential antimicrobial agents elevate the demand for the development of a strategy to improve the availability and activity of such hydrophobic drug molecules in aqueous biological systems. In this direction, the nanoprecipitation technique may offer a simpler, less complex, more feasible, and widely applicable method to encapsulate the hydrophobic drug without the help of any additive for particle stabilization …”

Section: Introductionmentioning

confidence: 99%

“…In this direction, the nanoprecipitation technique may offer a simpler, less complex, more feasible, and widely applicable method to encapsulate the hydrophobic drug without the help of any additive for particle stabilization. 31 Furthermore, several polymeric nanoparticles have been used for encapsulating hydrophobic drugs via the nanoprecipitation method. 32 Solvent-based precipitation technique was first used to develop a nanocapsule of poly(D,L-lactide) encapsulating indomethacin as a drug model.…”

Section: ■ Introductionmentioning

confidence: 99%

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Bioactive Peptide Nano-assemblies with pH-Triggered Shape Transformation for Antibacterial Therapy

Pal¹,

Roy²

2022

ACS Appl. Nano Mater.

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Peptide-based supramolecular nano-assemblies have received much attention due to their importance in drug delivery, therapeutics, and tissue regeneration. Recent developments in dynamic self-assembly have shifted the emphasis toward producing novel nanostructures with stimuli-responsive assembly behavior. Here, we report the fabrication of a bio-nano construct with dual functionality and environmental tunability, offering advancements in wound healing applications. In particular, we have utilized a collagen-inspired peptide amphiphile to fabricate spherical nanoparticles via nanoprecipitation and explored its unique intrinsic stimuli-responsive self-assembling property to encapsulate and release the hydrophobic drug, ferulic acid. The peptide-based spherical nanoparticles demonstrated a dynamic behavior and a shape transition into nanofibers when exposed to the basic chronic wound environment, triggering the release of the encapsulated ferulic acid. The structural transformation of the nanoparticles into the nanofibers provided an advanced synthetic scaffold for wound closure, while the released ferulic acid provided assistance in combating microbial infection to offer a dual advantage of the nano construct. Interestingly, the novel nanocarrier demonstrated an enhanced efficacy in the bactericidal effect offered by ferulic acid. Such transmorphic behavior of the peptide could be used for constructing stimuli-responsive nano-assemblies for overcoming the limitations of hydrophobic drugs in therapeutics.

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Section: Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Bioactive Peptide Nano-assemblies with pH-Triggered Shape Transformation for Antibacterial Therapy

Pal¹,

Roy²

2022

ACS Appl. Nano Mater.

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“…The high antioxidant activity and radical scavenging effect of eugenol is the result of its phenolic hydroxyl groups, which remain stable during the film development process [ 36 ]. Similarly, linalool, another chemical compound present in orange and cinnamon oils ( Table S1 ), has been recognized for its antioxidant and antibacterial activity [ 37 , 38 ]. When examining the antioxidant activity of 25 essential oils used for medicinal purposes, Wei and Shibamoto [ 39 ] showed that clove (52%) and cinnamon (23%) oils had antioxidant activity superior to that of chamomile (20%), anise (20%), rosemary (10%) and orange (9%) EOs.…”

Section: Resultsmentioning

confidence: 99%

The Use of Biopolymers as a Natural Matrix for Incorporation of Essential Oils of Medicinal Plants

Puscaselu

Lobiuc

Sîrbu

et al. 2022

Gels

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The benefits of using biopolymers for the development of films and coatings are well known. The enrichment of these material properties through various natural additions has led to their applicability in various fields. Essential oils, which are well-known for their beneficial properties, are widely used as encapsulating agents in films based on biopolymers. In this study, we developed biopolymer-based films and tested their properties following the addition of 7.5% and 15% (w/v) essential oils of lemon, orange, grapefruit, cinnamon, clove, chamomile, ginger, eucalyptus or mint. The samples were tested immediately after development and after one year of storage in order to examine possible long-term property changes. All films showed reductions in mass, thickness and microstructure, as well as mechanical properties. The most considerable variations in physical properties were observed in the 7.5% lemon oil sample and the 15% grapefruit oil sample, with the largest reductions in mass (23.13%), thickness (from 109.67 µm to 81.67 µm) and density (from 0.75 g/cm3 to 0.43 g/cm3). However, the microstructure of the sample was considerably improved. Although the addition of lemon essential oil prevented the reduction in mass during the storage period, it favored the degradation of the microstructure and the loss of elasticity (from 16.7% to 1.51% for the sample with 7.5% lemon EO and from 18.28% to 1.91% for the sample with 15% lemon EO). Although the addition of essential oils of mint and ginger resulted in films with a more homogeneous microstructure, the increase in concentration favored the appearance of pores and modifications of color parameters. With the exception of films with added orange, cinnamon and clove EOs, the antioxidant capacity of the films decreased during storage. The most obvious variations were identified in the samples with lemon, mint and clove EOs. The most unstable samples were those with added ginger (95.01%), lemon (92%) and mint (90.22%).

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“…Docking studies performed on the two molecules with both programs (CLC and Molegro) reveal that docking scores are favorable for the two molecules. Studies performed on this microorganism with a mixture of clotrimazole (0.1%) and various sources of citrus essential oils (1.9%) reveal a clear synergistic effect in the case of different sources of limonene, such as essential oils from Citrus reticulata (red), Citrus reticulata (green), and Citrus paradisi , probably because these essential oils contain limonene and or/linalool (Citrus paradisi essential oil) [ 56 , 57 ]. In agreement with the results obtained by Guimarães and collab., beta-pinene and gamma-terpinene do not exhibit antimicrobial activity on S. aureus [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

Studies Regarding the Antimicrobial Behavior of Clotrimazole and Limonene

et al. 2022

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The paper presents the results of the studies performed to establish the effect of the mixtures between limonene and clotrimazole against microbial pathogens involved in dermatological diseases, such as Candida albicans, Staphyloccocus aureus, and Escherichia coli. Preliminary data obtained from the studies performed in microplates revealed a possible synergism between the mixture of clotrimazole and limonene for Staphylococcus aureus. Studies performed “in silico” with programs such as CLC Drug Discovery Workbench and MOLEGRO Virtual Docker, gave favorable scores for docking each compound on a specific binding site for each microorganism. The tests performed for validation, with the clotrimazole (0.1%) and different sources of limonene (1.9% citrus essential oils), showed a synergistic effect on Staphylococcus aureus in the case of the mixtures between clotrimazole and the essential oils of Citrus reticulata or Citrus paradisi. The studies performed on Staphylococcus aureus MRSA showed a synergistic effect between clotrimazole and the essential oils obtained from Citrus bergamia, Citrus aurantium, or Citrus paradisi. In the case of Pseudomonas aeruginosa, essential oils and clotrimazole used alone did not exhibit antimicrobial activities, but the mixtures between clotrimazole and the essential oils of Citrus bergamia or Citrus sinensis exhibited a synergistic antimicrobial effect.

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The performance evaluation of Eugenol and Linalool microencapsulated by PLA on their activities against pathogenic bacteria

Cited by 14 publications

References 43 publications

Bioactive Peptide Nano-assemblies with pH-Triggered Shape Transformation for Antibacterial Therapy

Bioactive Peptide Nano-assemblies with pH-Triggered Shape Transformation for Antibacterial Therapy

The Use of Biopolymers as a Natural Matrix for Incorporation of Essential Oils of Medicinal Plants

Studies Regarding the Antimicrobial Behavior of Clotrimazole and Limonene

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