The perception of time in childhood migraine

Vicario, Carmelo M.; Gulisano, Mariangela; Martino, Davide; Rizzo, Renata

doi:10.1177/0333102413517774

Cited by 7 publications

(6 citation statements)

References 18 publications

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“…Different forms of chronic pain may be accompanied by different arousal states, with different effect on time perception. Our findings for neuropathic pain are not consistent with those of previous human studies of migraineurs 21,22,51 . These subjects may maintain high arousal states for some time, especially during pain attacks 59 .…”

Section: Discussioncontrasting

confidence: 99%

“…In contrast, after SNL surgery, rats’ P L s were lower when judging tone duration, with no change in the PSE or temporal sensitivity, in this study. Time perception is more complex in patients with chronic pain 21,22,51 . The impairment of arousal and attention caused by chronic pain may co-contribute to the effect of this type of pain on time perception.…”

Section: Discussionmentioning

confidence: 99%

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Formalin-induced and neuropathic pain altered time estimation in a temporal bisection task in rats

Liu

Wang

et al. 2019

Sci Rep

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Time perception is an important ability that is related closely to humans’ and animals’ daily activities. It can be distorted by various emotional states. In human studies, experimental pain has been shown to prolong the perception of time. However, related animal studies are lacking. In this study, we used a temporal bisection task to investigate how acute inflammatory pain (induced by hind-paw formalin injection) and chronic neuropathic pain [induced by spinal nerve ligation (SNL)] affected time perception in rats. Rats were trained to recognize “short” (1200-ms) and “long” (2400-ms) anchor-duration pure tones and were rewarded for corresponding lever presses. During testing, rats perceived a series of intermediate-duration and anchor-duration pure tones, and selected levers corresponding to the “short” and “long” tones. After formalin injection, rats gave more “long” lever-press responses than after saline injection. The point of subjective equality after formalin injection also increased, suggesting that formalin-induced acute pain extended time perception. In contrast, rats that had undergone SNL gave fewer “long” lever-press responses compared with the sham surgery group. This animal study suggests that formalin-induced pain and neuropathic pain may have different effects on time perception.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Formalin-induced and neuropathic pain altered time estimation in a temporal bisection task in rats

Liu

Wang

et al. 2019

Sci Rep

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“…This pattern was replicated in a subsequent work (Zhang et al, 2012) in the absence of depression. More recently, a time overestimation response of supra-second durations was reported in a sample of adolescents affected by migraine (Vicario et al, 2014). In a recent review, Borsook et al (2016) linked migraine with structural and functional alterations of insula.…”

Section: Migrainementioning

confidence: 98%

Time Processing, Interoception, and Insula Activation: A Mini-Review on Clinical Disorders

et al. 2020

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Time processing is a multifaceted skill crucial for managing different aspects of life. In the current work, we explored the relationship between interoception and time processing by examining research on clinical models. We investigated whether time processing deficits are associated with dysfunction of the interoceptive system and/or insular cortex activity, which is crucial in decoding internal body signaling. Furthermore, we explored whether insular activation predicts the subjective experience of time (i.e., the subjective duration of a target stimulus to be timed). Overall, our work suggests that alteration of the interoceptive system could be a common psychophysiological hallmark of mental disorders affected by time processing deficits.

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“…Indeed, both temporal over and underestimation have been reported during painful stimulation. Longer perceived durations for painful than neutral stimuli have been described in animals [ 9 ] and in healthy humans using prospective time judgments (time reproduction and production, verbal estimation) during electric shock [ 10 , 11 ] and hot thermal stimulation [ 12 ], and in adult [ 13 ] and pediatric [ 14 ] population of migraineurs. On the contrary shorter estimates have been observed in humans using retrospective time judgments (verbal estimation) during cold thermal stimulation [ 15 ] and in patients with chronic headache [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Modulation of neural circuits underlying temporal production by facial expressions of pain

et al. 2018

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According to the Scalar Expectancy Theory, humans are equipped with a biological internal clock, possibly modulated by attention and arousal. Both emotions and pain are arousing and can absorb attentional resources, thus causing distortions of temporal perception. The aims of the present single-event fMRI study were to investigate: a) whether observation of facial expressions of pain interferes with time production; and b) the neural network subserving this kind of temporal distortions. Thirty healthy volunteers took part in the study. Subjects were asked to perform a temporal production task and a concurrent gender discrimination task, while viewing faces of unknown people with either pain-related or neutral expressions. Behavioural data showed temporal underestimation (i.e., longer produced intervals) during implicit pain expression processing; this was accompanied by increased activity of right middle temporal gyrus, a region known to be active during the perception of emotional and painful faces. Psycho-Physiological Interaction analyses showed that: 1) the activity of middle temporal gyrus was positively related to that of areas previously reported to play a role in timing: left primary motor cortex, middle cingulate cortex, supplementary motor area, right anterior insula, inferior frontal gyrus, bilateral cerebellum and basal ganglia; 2) the functional connectivity of supplementary motor area with several frontal regions, anterior cingulate cortex and right angular gyrus was correlated to the produced interval during painful expression processing. Our data support the hypothesis that observing emotional expressions distorts subjective time perception through the interaction of the neural network subserving processing of facial expressions with the brain network involved in timing. Within this frame, middle temporal gyrus appears to be the key region of the interplay between the two neural systems.

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The perception of time in childhood migraine

Cited by 7 publications

References 18 publications

Formalin-induced and neuropathic pain altered time estimation in a temporal bisection task in rats

Formalin-induced and neuropathic pain altered time estimation in a temporal bisection task in rats

Time Processing, Interoception, and Insula Activation: A Mini-Review on Clinical Disorders

Modulation of neural circuits underlying temporal production by facial expressions of pain

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