The perception of self-produced sensory stimuli in patients with auditory hallucinations and passivity experiences: evidence for a breakdown in self-monitoring

Blakemore, Sarah‐Jayne; Smith, Julie M.; Steel, Robby M.; Johnstone, Eve C.; Frith, C. D.

doi:10.1017/s0033291799002676

Cited by 429 publications

(318 citation statements)

References 33 publications

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“…Patients with positive symptoms tend to overattribute to themselves actions performed by others or, conversely, to attribute their own actions or thoughts to the influence of others. When placed in experimental situations like those already described in the previous sections, these patients were found to systematically misattribute their movements or those of the experimenter [15,16,28,60].…”

Section: Conclusion a Neural Hypothesis For Self-recognition And Itsmentioning

confidence: 84%

The mechanism of self-recognition in humans

Jeannerod

2003

Behavioural Brain Research

417

256

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Recognizing oneself as the owner of a body and the agent of actions requires specific mechanisms which have been elucidated only recently. One of these mechanisms is the monitoring of signals arising from bodily movements, i.e. the central signals which contribute to the generation of the movements and the sensory signals which arise from their execution. The congruence between these two sets of signals is a strong index for determining the experiences of ownership and agency, which are the main constituents of the experience of being an independent self. This mechanism, however, does not account from the frequent cases where an intention is generated but the corresponding action is not executed. In this paper, it is postulated that such covert actions are internally simulated by activating specific cortical networks or representations of the intended actions. This process of action simulation is also extended to the observation and the recognition of actions performed or intended by other agents. The problem of disentangling representations that pertain to self-intended actions from those that pertain to actions executed or intended by others, is a critical one for attributing actions to their respective agents. Failure to recognize one's own actions and misattribution of actions may result from pathological conditions which alter the readability of these representations.

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Section: Conclusion a Neural Hypothesis For Self-recognition And Itsmentioning

confidence: 84%

The mechanism of self-recognition in humans

Jeannerod

2003

Behavioural Brain Research

417

256

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“…Those without delusions of control or other symptoms (regardless of diagnosis) reported that self produced sensations were less tickly, intense and pleasant than those produced by the experimenter. Those with delusions of control or other symptoms (regardless of diagnosis) by contrast reported no difference between self and other produced stimuli on any of these scales (Blakemore et al, 2000(Blakemore et al, , p. 1136). This suggests that those with delusions of control could not tell who produced the action.…”

Section: Self Ticklingmentioning

confidence: 99%

“…It may be that in normal subjects self produced stimuli appear less intense because they are predicted based on the motor commands (Blakemore et al, 2000(Blakemore et al, , p. 1137. If those suffering delusions of control fail to produce predictions, or lack appropriate access to them, this phenomenon could not occur.…”

Section: Self Ticklingmentioning

confidence: 99%

The case for the comparator model as an explanation of the sense of agency and its breakdowns

Carruthers

2012

Consciousness and Cognition

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a b s t r a c t I compare Frith and colleagues' influential comparator account of how the sense of agency is elicited to the multifactorial weighting model advocated by Synofzik and colleagues. I defend the comparator model from the common objection that the actual sensory consequences of action are not needed to elicit the sense of agency. I examine the comparator model's ability to explain the performance of healthy subjects and those suffering from delusions of alien control on various self-attribution tasks. It transpires that the comparator model needs case-by-case adjustment to deal with problematic data. In response to this, the multifactorial weighting model of Synofzik and colleagues is introduced. Although this model is incomplete, it is more naturally constrained by the cases that are problematic for the comparator model. However, this model may be untestable. I conclude that currently the comparator model approach has stronger support than the multifactorial weighting model approach.

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“…Consistent with this, patients who suffer from hallucinations and delusions exhibit unusually large responses to predictable or unimportant stimuli (Jensen et al, 2008), and smaller responses to important stimuli compared to controls (Murray et al, 2008). Additionally, high-level systems fail to predict and downregulate responses to the sensory consequences of patients' own actions or speech (Blakemore et al, 2000;Ford & Mathalon, 2004;Shergill et al, 2005). It therefore seems likely that hallucinations and delusions are linked to abnormal communication and connectivity between high-level and sensory cortex (Mechelli et al, 2007).…”

Section: Hallucinations and Delusionsmentioning

confidence: 99%

Laminar fMRI: Applications for cognitive neuroscience

et al. 2019

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Highlights Recent developments in high spatial resolution fMRI allow for functional imaging of human cortical layers (laminar fMRI)  Feedforward and feedback responses can be dissociated by their laminar profiles  In vivo measurements of feedforward and feedback responses in humans with laminar fMRI have many, far-reaching applications for cognitive neuroscience  We review recent laminar fMRI studies, and several areas of cognitive neuroscience that stand to benefit from this exciting technological development AbstractThe cortex is a massively recurrent network, characterised by feedforward and feedback connections between brain areas as well as lateral connections within an area. areas at a more fine-grained level than previously possible in the human species. In this review,we highlight recent studies that successfully used laminar fMRI to isolate layer-specific feedback responses in human sensory cortex. In addition, we review several areas of cognitive neuroscience that stand to benefit from this new technological development, highlighting contemporary hypotheses that yield testable predictions for laminar fMRI. We hope to encourage researchers with the opportunity to embrace this development in fMRI research, as we expect that many future advancements in our current understanding of human brain function will be gained from measuring lamina-specific brain responses.

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The perception of self-produced sensory stimuli in patients with auditory hallucinations and passivity experiences: evidence for a breakdown in self-monitoring

Abstract: Background. To test the hypothesis that certain psychotic symptomatology is due to a defect in selfmonitoring, we investigated the ability of groups of psychiatric patients to differentiate perceptually between self-produced and externally produced tactile stimuli.

Cited by 429 publications

References 33 publications

The mechanism of self-recognition in humans

The mechanism of self-recognition in humans

The case for the comparator model as an explanation of the sense of agency and its breakdowns

Laminar fMRI: Applications for cognitive neuroscience

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