The Peptide That Binds

MacDonald, Kai; MacDonald, Tina Marie

doi:10.3109/10673220903523615

Cited by 537 publications

(201 citation statements)

References 161 publications

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“…They stated that due to its size and short half‐life, oxytocin might be unable to enter the oral mucosa from the blood. On the other hand, other studies did detect oxytocin in the saliva of humans, including changes in that oxytocin after exposure to different behavioural paradigms 8, 9, 25. As stated in the introduction, these enzyme immunoassay‐based findings could be due to the cross‐reactivity of molecules other than oxytocin 12, but it is also possible that the detected molecules were indeed oxytocin from a central or even a local origin.…”

Section: Discussionmentioning

confidence: 93%

“…The functioning of the oxytocin system has frequently been reported as crucial for the expression of, and readiness for, caregiving behaviours 7, 8, and we therefore selected oxytocin as a biological marker of interest to assess during Kangaroo care. This had been done once before by Cong et al 9, who showed that after 30 minutes, Kangaroo care appeared to activate a release of oxytocin in the saliva of both mothers and fathers.…”

Section: Introductionmentioning

confidence: 99%

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Pilot study demonstrates that salivary oxytocin can be measured unobtrusively in preterm infants

et al. 2016

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AimThis study assessed the feasibility and obtrusiveness of measuring salivary oxytocin in preterm infants receiving Kangaroo care, because this is a period of maximal bonding or co‐regulation. We also analysed possible influential determinants, including maternal oxytocin.MethodsThe saliva of preterm infants and their mothers was collected prior to, and during, Kangaroo care using cotton swabs and pooled into vials until sufficient volumes were obtained to measure oxytocin levels using a radioimmunoassay. The obtrusiveness of the infants’ collections was measured with a Likert scale.ResultsSaliva was collected unobtrusively prior to, and during, 30 Kangaroo care sessions in 21 preterm infants. This resulted in three vials with sufficient volumes of before‐Kangaroo care saliva and three with during‐Kangaroo care saliva. Oxytocin was detectable in all six vials. The Kangaroo care duration and the intensity of the mother–infant interaction before and during Kangaroo care seemed to be the most important determinants, and these should preferably be standardised in any future trials.ConclusionOxytocin was measured unobtrusively in the pooled saliva of preterm infants both before and during Kangaroo care and could therefore be investigated as a biomarker in future studies.

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Pilot study demonstrates that salivary oxytocin can be measured unobtrusively in preterm infants

et al. 2016

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“…Oxytocin is a crucial neuropeptide for learning, memory, and organization of behaviors in the mammalians [22]. Central oxytocin receptors are widely found in the brain in the hippocampus, amygdala, striatum, hypothalamus, nucleus accumbens, and midbrain and play an important role in the formation of memory [23].…”

Section: Focusing Attention On a Specific Point Creating An Expectationmentioning

confidence: 99%

Methodological Approach in Perception Management

Cabıoğlu¹,

İşeri²

2015

OALib

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Perception is the interpretation of the sensory stimuli received from the environment. Visual, auditory, and tactile senses are collected and interpreted in the "General Interpretation Area" (Wernicke's area). This area alone plays a much more active role than all other regions of the cortex in the comprehension of the brain called intelligence. We comprehend the events as a whole with the combination of the visual, auditory, and tactile perceptions in the Wernicke's area; the events remain longer in our memory and its impact on us is stronger. This situation is called multi-sensory perception. Different pressure groups are in an effort to influence the feelings, sensations, systems of thought, and actions of their target population in order to ensure their target population to behave in line with their targets. In this respect, "Perception Management" is defined as all activities that are performed to influence the thoughts of a target population. Modeling, focusing attention on a specific point, creating an expectation, participation, rewarding, punishment, and stress management are among the methods applied in perception management. If we learn these methodological approaches used in perception management, we are in the opinion that it would be easy for individuals to decide independently by preventing them from the influence and manipulation of different pressure groups on their decision-making processes. Today, pressure groups aim at managing the community in line with their targets by influencing single individuals mostly using the perception management method.

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“…These data provide convergent support for the hypothesis that paternally expressed imprinted genes promote enhanced suckling in mouse neonates and human infants, through effects that include: (i) the development of oro-facial musculature involved in suckling, (ii) size of the tongue (which serves as a 'suction pump' for milk extraction), (iii) the intensity of ultrasonic vocalizations (in mice) or crying (in humans), and (iv) motivation to suckle. Proximate mechanisms underlying these effects include the presence of an enhancer for IGF2 expression with differential effects on growth of tongue and skeletal muscle in mice [70], and roles for the imprinted genes Peg3, Peg1, and Ndn-hub' genes in Varrault et al's [16] imprinted-gene network-in promoting development of hypothalamic neurons that secrete oxytocin, a peptide hormone that motivates early bidirectional social bonding [71].…”

Section: A Greater and Longer Childhoodmentioning

confidence: 99%

The evolutionary biology of child health

Crespi

2011

Proc. R. Soc. B.

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I apply evolutionary perspectives and conceptual tools to analyse central issues underlying child health, with emphases on the roles of human-specific adaptations and genomic conflicts in physical growth and development. Evidence from comparative primatology, anthropology, physiology and human disorders indicates that child health risks have evolved in the context of evolutionary changes, along the human lineage, affecting the timing, growth-differentiation phenotypes and adaptive significance of prenatal stages, infancy, childhood, juvenility and adolescence. The most striking evolutionary changes in humans are earlier weaning and prolonged subsequent pre-adult stages, which have structured and potentiated maladaptations related to growth and development. Data from human genetic and epigenetic studies, and mouse models, indicate that growth, development and behaviour during pre-adult stages are mediated to a notable degree by effects from genomic conflicts and imprinted genes. The incidence of cancer, the primary cause of non-infectious childhood mortality, mirrors child growth rates from birth to adolescence, with paediatric cancer development impacted by imprinted genes that control aspects of growth. Understanding the adaptive significance of child growth and development phenotypes, in the context of human-evolutionary changes and genomic conflicts, provides novel insights into the causes of disease in childhood.

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The Peptide That Binds

Cited by 537 publications

References 161 publications

Pilot study demonstrates that salivary oxytocin can be measured unobtrusively in preterm infants

Pilot study demonstrates that salivary oxytocin can be measured unobtrusively in preterm infants

Methodological Approach in Perception Management

The evolutionary biology of child health

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