The collagen prolyl 4-hydroxylases (C-P4Hs) catalyze the formation of 4-hydroxyproline by the hydroxylation of proline residues in -Xaa-Pro-Gly-sequences. The vertebrate enzymes are ␣ 2 ␤ 2 tetramers in which protein-disulfide isomerase serves as the ␤ subunit. Two isoforms of the catalytic ␣ subunit have been identified and shown to form [␣(I)] 2 ␤ 2 and [␣(II)] 2 ␤ 2 tetramers, the type I and type II C-P4Hs, respectively. The peptide-substrate-binding domain of type I C-P4H has been shown to be located betw…
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