The Penetration and Clearance of Dimethyl Sulfoxide From the Rat Eye After Topical Application*

Weaver, William J.; Hill, Robert V.; Weber, Frank; Jacob, Stanley W.

doi:10.1111/j.1749-6632.1975.tb25353.x

Cited by 5 publications

(2 citation statements)

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“…However, it turned out that with their help it is possible to significantly influence the pharmacological activity of drugs and regulate the parameters of pharmacokinetics and pharmacodynamics [4][5][6]. For example, dimethyl sulfoxide added to eye drops accelerates the penetration of antibiotics into the eye tissue [7,8]. The use of methylcellulose allows the drugs to be retained in tissues for a long time, prolonging their action [9].…”

Section: Introductionmentioning

confidence: 99%

Prolonging effect of polyvinyl alcohol on the drug release

et al. 2022

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Polymers are currently of interest as drug delivery systems. The use of polymeric forms of medicinal substances will eliminate or reduce the disadvantages of traditional drugs. The purpose of this work was to assess the ability to prolong the action of polyvinyl alcohol in relation to the drug release when going from dilute to more concentrated solutions. It was established that an increase in the viscosity of the polymer in solution caused by an increase in its concentration results not only in a slowdown in the diffusion of drugs from the polymer solution, but also in a significant decrease in the amount of drugs firmly fixed on the polymer matrix. Since it is the adduct of the polyvinyl alcohol-drug interaction that provides the slow release of the drug from the polymer solution, a decrease in its amount leads to the fact that no enhancement of the prolonging action is observed. It is claimed that when moving from solutions to polymer films, the rate of drug release is also determined by the structure of the polymer matrix. The lower the density of the polymer film, the greater the diffusion coefficient of the drug release from the film. Thus, in the course of evaluating the ability to prolong the action of polyvinyl alcohol, it was shown that using some prolongation techniques, it is possible to achieve targeted regulation of the rate of drug release from polymer dosage forms.

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Section: Introductionmentioning

confidence: 99%

Prolonging effect of polyvinyl alcohol on the drug release

et al. 2022

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“…[3][4][5] DMSO/water mixtures are also widely used for evaluating protein and enzymatic activity. [2,[6][7][8] Apart from their many useful applications in biotechnological fields, DMSO/water mixtures also display the strongest deviation from ideal mixing behavior leading to interesting and anomalous variation in many macroscopic properties such as viscosi-ty, [9,10] surface tension, [11,12] isothermal and adiabatic compressibility, [13] etc.i nt he composition range of X DMSO = 30-50 %. The most unique abnormality of DMSO/waterm ixtures is evident in the freezing point of the DMSO/water mixture, which goes down to less than À70 8Ca tt he eutectic composition (X DMSO % 35 %).…”

Section: Introductionmentioning

confidence: 99%

Proton Transfer Reaction Dynamics of Pyranine in DMSO/Water Mixtures

Awasthi¹,

Singh

2017

ChemPhysChem

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Photoinduced intermolecular excited-state proton transfer (ESPT) reactions are ubiquitous in chemistry and biology. ESPT reactions are extremely sensitive to the nature of water molecules in its microenvironment and thus serve as a sensitive reporter for the water structure and dynamics in a system. Herein, the photoinduced intermolecular ESPT reaction of 8-hydroxypyrene-1,3,5-trisulfonic acid (HPTS, also known as pyranine) has been investigated in various DMSO/water mixtures by using steady-state and time-resolved emission spectroscopy. The DMSO/water binary mixture yields an interesting and anomalous behavior for the proton transfer reaction dynamics of HPTS at a mole fraction of DMSO (X ) of 0.41-0.51, which has also been previously investigated and projected as an anomalous region by molecular dynamics simulation and other experimental techniques. The extreme slowdown of the proton transfer reaction observed at X =0.41-0.51 has been attributed to the slow solvation dynamics, as well as the non-availability of free water molecules at this composition, which are required to solvate the newly generated proton. These observations have been also corroborated by time-resolved area-normalized emission spectra. The dimensionality of the proton diffusion process has been investigated by analyzing the geminate recombination process, and is found to be significantly different in DMSO/water mixtures (X =0.41-0.51) compared with three-dimensional proton diffusion in neat water.

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Dimethyl sulfoxide

Willhite

Katz

1984

J of Applied Toxicology

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The Penetration and Clearance of Dimethyl Sulfoxide From the Rat Eye After Topical Application*

Cited by 5 publications

References 1 publication

Prolonging effect of polyvinyl alcohol on the drug release

Prolonging effect of polyvinyl alcohol on the drug release

Proton Transfer Reaction Dynamics of Pyranine in DMSO/Water Mixtures

Dimethyl sulfoxide

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