The PediPump: A New Ventricular Assist Device for Children

Duncan, Brian W.; Lorenz, Markus; Kopcak, Michael W.; Fukamachi, Kiyotaka; Ootaki, Yoshio; Chen, H. Ming; Chapman, P. A.; Davis, Steven J.; Smith, William A.

doi:10.1111/j.1525-1594.2005.29088.x

Cited by 28 publications

(13 citation statements)

References 13 publications

(12 reference statements)

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“…They include two axial flow devices: PediPump by the Cleveland Clinic and pediatric Jarvik 2000 by Jarvik Heart, Inc. (10)(11)(12)(13). The University of Pittsburgh group combined the features of the axial and centrifugal blood pumps for unique design of a mixed flow device called "PediaFlow" (14).…”

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confidence: 99%

Computational Fluid Dynamics Analysis of the Pediatric Tiny Centrifugal Blood Pump (TinyPump)

et al. 2006

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We have developed a tiny rotary centrifugal blood pump for the purpose of supporting circulation of children and infants. The pump is designed to provide a flow of 0.1-4.0 L/min against a head pressure of 50-120 mm Hg. The diameter of the impeller is 30 mm with six straight vanes. The impeller is supported by a hydrodynamic bearing at its center and rotated with a radial coupled magnetic driver. The bearing that supports rotation of the impeller of the tiny centrifugal blood pump is very critical to achieve durability, and clot-free and antihemolytic performance. In this study, computational fluid dynamics (CFD) analysis was performed to quantify the secondary flow through the hydrodynamic bearing at the center of the impeller and investigated the effects of bearing clearance on shear stress to optimize hemolytic performance of the pump. Two types of bearing clearance (0.1 and 0.2 mm) were studied. The wall shear stress of the 0.1-mm bearing clearance was lower than that of 0.2-mm bearing clearance at 2 L/min and 3000 rpm. This was because the axial component of the shear rate significantly decreased due to the narrower clearance even though the circumferential component of the shear rate increased. Hemolysis tests showed that the normalized index of hemolysis was reduced to 0.0076 g/100 L when the bearing clearance was reduced to 0.1 mm. It was found that the CFD prediction supported the experimental trend. The CFD is a useful tool for optimization of the hydrodynamic bearing design of the centrifugal rotary blood pump to optimize the performance of the pump in terms of mechanical effect on blood cell elements, durability of the bearing, and antithrombogenic performance.

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confidence: 99%

Computational Fluid Dynamics Analysis of the Pediatric Tiny Centrifugal Blood Pump (TinyPump)

et al. 2006

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“…The Cleveland Clinic PediPump is depicted in Figure 3. 49,50 The support of early technology development provided by this program will hopefully yield several devices that are clinically useful in the future.…”

Section: The Pediatric Circulatory Support Program Of the National Hementioning

confidence: 98%

Pediatric Mechanical Circulatory Support

Duncan

2005

ASAIO Journal

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Extracorporeal membrane oxygenation (ECMO) is based on technology that has been used clinically for decades. Largely because of its widespread use in pediatric patients with respiratory failure, familiarity with this technology has established ECMO as the most commonly used form of circulatory support for children. However, clinical applications and technical aspects of ECMO support continue to evolve, ensuring the ongoing importance of this modality for pediatric circulatory support. Although traditionally lagging behind development for adult applications, the use of ventricular assist devices (VADs) is expanding in pediatrics. Of particular interest, a number of new VADs designed specifically for children are becoming available, while early development of some innovative devices for pediatric circulatory support is currently underway.

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“…33 The enabling technology for the PediPump is derived from an adult "catheter" pump in development by The Cleveland Clinic's Department of Biomedical Engineering and Foster-Miller Technologies, Inc. Because its capabilities are packaged into a small size, the resulting basic pump design provides support for the entire range of patient sizes encountered in pediatrics.…”

Section: The Pedipump (The Cleveland Clinic Foundation)mentioning

confidence: 99%

The National Heart, Lung, and Blood Institute Pediatric Circulatory Support Program

et al. 2006

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Abstract-Options for the circulatory support of pediatric patients under the age of 5 years are currently limited to short-term extracorporeal devices, the use of which is often complicated by infection, bleeding, and thromboembolism. Recognizing this void, the National Heart, Lung, and Blood Institute solicited proposals for the development of novel circulatory support systems for infants and children from 2 to 25 kg with congenital or acquired cardiovascular disease. Five contracts were awarded to develop a family of devices that includes (1) an implantable mixed-flow ventricular assist device designed specifically for patients up to 2 years of age, (2) another mixed-flow ventricular assist device that can be implanted intravascularly or extravascularly depending on patient size, (3) compact integrated pediatric cardiopulmonary assist systems, (4) apically implanted axial-flow ventricular assist devices, and (5)

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The PediPump: A New Ventricular Assist Device for Children

Cited by 28 publications

References 13 publications

Computational Fluid Dynamics Analysis of the Pediatric Tiny Centrifugal Blood Pump (TinyPump)

Computational Fluid Dynamics Analysis of the Pediatric Tiny Centrifugal Blood Pump (TinyPump)

Pediatric Mechanical Circulatory Support

The National Heart, Lung, and Blood Institute Pediatric Circulatory Support Program

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