The Pediatric and Perinatal Autopsy Manual

Cohen, Marta C.; Scheimberg, Irene

doi:10.1017/cbo9781139237017

Cited by 12 publications

(29 citation statements)

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“…Group B streptococcus can also manifest as diffuse alveolar damage (DAD) with hyaline membrane formation (23). Hemophilus influenza infection can also present with a similar DAD pattern of lung injury (12). Group A streptococcus (GAS) infection may present as an acute pneumonia, necrotizing fasciitis, erysipelas, cellulitis, osteomyelitis, septic arthritis, meningitis, or toxic shock syndrome (24).…”

Section: Sepsis In the Neonatementioning

confidence: 99%

“…Disseminated intravascular coagulopathy has a heterogeneous picture that includes intravascular thrombi and parenchymal hemorrhage in various organs. Acute thymic stress atrophy may also be evident, especially with a more prolonged and/ or severe antemortem clinical course (12). Correlation with antenatal history (particularly the maternal GBS status) and results from microbiologic studies is essential to confirm GBS and GAS as etiologic organisms for septic deaths, particularly when a septic focus is not evident histologically.…”

Section: Sepsis In the Neonatementioning

confidence: 99%

“…Ideally, at least one section per lung lobe should be examined histologically. Pulmonary congestion, acute intraalveolar hemorrhage, edema, and septal hemorrhage are common autopsy findings, especially after resuscitation attempts (12). An iron stain assists with dating the chronicity of hemorrhage and a PAS stain may highlight pulmonary edema.…”

Section: Respiratory System (One Section Of Glottis Trachea and Onementioning

confidence: 99%

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Histopathologic Analysis in Sudden Infant and Child Deaths

D’Arcy¹,

Hazrati²,

Chiasson³

2018

Academic Forensic Pathology

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The forensic pathologist responsible for sudden unexpected death (SUD) investigation in the pediatric setting faces many challenges. It usually takes many years to obtain reasonable experience and exposure to the wide variety of diseases that may present as SUD in a pediatric context, and to appreciate the differences in the etiology and clinical context between the pediatric and adult SUD setting. In pediatric SUD, it is necessary to conduct a systematic, pediatric-focused autopsy investigation including extensive histopathological assessment and ancillary testing. Postmortem histologic findings in the context of SUD in the pediatric population are often subtle and distinctly different from those seen in the adult population. The pathologist must have an understanding of both developmental and pathological processes in order to correctly interpret the findings during a pediatric autopsy. A system-based, histopathology-focused review of common entities, normal variants, and incidental findings that can prove challenging will be discussed. For the forensic pathologist tasked with pediatric SUD autopsies, development of a strong collaborative relationship with a pediatric pathologist and/or neuropathologist to assist with histopathological analysis is strongly endorsed.

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Section: Sepsis In the Neonatementioning

confidence: 99%

Section: Sepsis In the Neonatementioning

confidence: 99%

Section: Respiratory System (One Section Of Glottis Trachea and Onementioning

confidence: 99%

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Histopathologic Analysis in Sudden Infant and Child Deaths

D’Arcy¹,

Hazrati²,

Chiasson³

2018

Academic Forensic Pathology

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“…An array of brilliant protocols is available, though none of them can be deemed sacrosanct, and one may adopt/adapt any technique to salvage the maximum information for the benefit of the family and the clinician. For an erudite discussion of the plethora of existing protocols, the reader should refer to them [2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Performing a Perinatal Autopsy

Jaiman

2015

Journal of Fetal Medicine

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Intrauterine fetal demise or termination for malformation is adverse obstetric outcomes, agonizing for the parents and frustrating for health care providers. These events are often unpredictable and investigation entails not only the evaluation of the fetus/neonate but also the placenta. Though nothing can compensate the bereavement of families who have encountered fetal or a neonatal loss, a meticulous study of the placental, fetal, and neonatal tissues provides succor and help in the healing process. In recent times, with extensive advances in the pediatric specialty, the significance and requirements for perinatal autopsy have also commensurately heightened. There is an inordinate need for an accurate diagnosis in order to render genetic counseling and ascertain the implications of possible recurrence in future pregnancies. A conscientious perinatal autopsy, supplemented by cytogenetic and metabolic evaluation, followed by dissemination of the information to the parents, clinicians, and public health organizations is of paramount importance. This not only assists in the clinical management and bereavement closure but also helps in the reduction of perinatal mortality and morbidity. An autopsy protocol assists in performing an adequate perinatal dissection, facilitates the recognition and documentation of all relevant information and in addition also provides a format for the collection, recording and presenting of data which facilitates collaborative research. A brief account of the benefits and techniques of perinatal autopsy and the protocol are presented.

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“…A recent textbook on Paediatric Autopsy may be a useful tool for both the general and paediatric pathologist. 3 …”

mentioning

confidence: 99%