The PD-L1/CD86 ratio is increased in dendritic cells co-infected with porcine circovirus type 2 and porcine reproductive and respiratory syndrome virus, and the PD-L1/PD-1 axis is associated with anergy, apoptosis, and the induction of regulatory T-cells in porcine lymphocytes

Richmond, O.; Cecere, Thomas E.; Erdoğan, Ergun; Meng, Xiang‐Jin; Piñeyro, Pablo; Subramaniam, Sakthivel; Todd, S. Michelle; LeRoith, Tanya

doi:10.1016/j.vetmic.2015.09.014

Cited by 19 publications

(24 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, although no differences were initially found between peach allergic patients and tolerant controls, PD‐L1 expression in DCs eventually increased during treatment by T12, in line with other studies . Moreover, we have observed an increase in PD‐L1/CD80 and PD‐L1/CD86 ratios for DCs, which has been shown previously as necessary for the induction and maintenance of Treg cells . These ratios were significantly increased at T6 and T12 in treated patients.…”

Section: Discussionsupporting

confidence: 91%

Immunological Changes Induced in Peach Allergy Patients with Systemic Reactions by Pru p 3 Sublingual Immunotherapy

Palomares

Gómez

Bogas

et al. 2018

Molecular Nutrition Food Res

View full text Add to dashboard Cite

Successful Pru p 3-enriched-SLIT is linked to an important immunosuppression of allergen-specific effector T cells, potentially due to an increase of allergen-specific Treg cells. These cellular changes are orchestrated by the activity of moDCs promoting the expression of PD-L1 that will participate in the regulatory response. These changes may serve as biomarkers during SLIT alongside other features such as IgE/IgG ratio.

show abstract

Section: Discussionsupporting

confidence: 91%

Immunological Changes Induced in Peach Allergy Patients with Systemic Reactions by Pru p 3 Sublingual Immunotherapy

Palomares

Gómez

Bogas

et al. 2018

Molecular Nutrition Food Res

View full text Add to dashboard Cite

show abstract

“…Previous studies have proven that IL-10 contributes to the development of immunosuppression in some virus infection hosts [25,26]. Regardless of whether in vivo and in vitro, IL-10 expression was significantly upregulated and associated with the development of immunosuppression during PCV2 infection [27,28]. In our previous studies, we identified that the PCV2 Cap protein induces IL-10 production in PAMs through the activation of the PI3K/Akt, ERK, p38-MAPK, and NF-κB p50 signaling pathway at the earlier phase of infection [13].…”

Section: Discussionmentioning

confidence: 98%

Porcine Circovirus Type 2 Rep Enhances IL-10 Production in Macrophages via Activation of p38-MAPK Pathway

Wang

Shi

et al. 2019

Viruses

View full text Add to dashboard Cite

Porcine circovirus type 2 (PCV2) is one of the major threats to pig farms worldwide. Although PCV2 has been identified to promote IL-10 production, the detailed regulatory roles of PCV2 Rep for IL-10 production remain unclear. Herein, we first found that PCV2 Rep, rather than PCV1 Rep, enhanced IL-10 expression at the later phase of PCV2 infection in porcine alveolar macrophages (PAMs). Furthermore, we found that PCV2 Rep directly activated the p38-MAPK pathway to promote transcription factors NF-κB p50 and Sp1 binding to the il10 promoter, but PCV1 Rep did not. During PCV2 infection, however, PCV2 Rep promoted the binding activities of NF-κB p50 and Sp1 with the il10 promoter only at the later phase of PCV2 infection, since Rep proteins only expressed at the later phase of the infection. Moreover, silence of the thymine DNA glycosylase (TDG), a Rep-binding protein, significantly reduced the binding activities of NF-κB p50 and Sp1 with il10 promoter, resulting in the reduction of IL-10 production in PCV2-inoculated PAMs at the later phase of infection. Taken together, our results demonstrate that Rep proteins enhance IL-10 production during PCV2 infection of PAMs via activation of p38-MAPK pathways, in which host TDG is a critical mediator.

show abstract

“…Furthermore, PCV2/PRRSV co-infection plays an immunomodulatory role in the pathogenesis of PCVAD by dramatically decreasing the total and differential leukocyte counts and inducing significantly higher numbers of T(regs) in dendritic cells (DCs) [69,70]. Thereafter, the levels of the inhibitory markers PD-L1 and IL-10 are significantly increased, while the level of the stimulatory markers CD86 is significantly decreased [71]. To date, effective treatment for PRRSV infection is not available, partly because co-infection with PCV2 and PRRSV may interfere with the vaccine.…”

Section: Co-infection Of Pcv2 With Other Swine Virusesmentioning

confidence: 99%

Co-Infection of Swine with Porcine Circovirus Type 2 and Other Swine Viruses

Ouyang

Zhang

Liu

et al. 2019

Viruses

136

144

View full text Add to dashboard Cite

Porcine circovirus 2 (PCV2) is the etiological agent that causes porcine circovirus diseases and porcine circovirus-associated diseases (PCVD/PCVAD), which are present in every major swine-producing country in the world. PCV2 infections may downregulate the host immune system and enhance the infection and replication of other pathogens. However, the exact mechanisms of PCVD/PCVAD are currently unknown. To date, many studies have reported that several cofactors, such as other swine viruses or bacteria, vaccination failure, and stress or crowding, in combination with PCV2, lead to PCVD/PCVAD. Among these cofactors, co-infection of PCV2 with other viruses, such as porcine reproductive and respiratory syndrome virus, porcine parvovirus, swine influenza virus and classical swine fever virus have been widely studied for decades. In this review, we focus on the current state of knowledge regarding swine co-infection with different PCV2 genotypes or strains, as well as with PCV2 and other swine viruses.

show abstract

The PD-L1/CD86 ratio is increased in dendritic cells co-infected with porcine circovirus type 2 and porcine reproductive and respiratory syndrome virus, and the PD-L1/PD-1 axis is associated with anergy, apoptosis, and the induction of regulatory T-cells in porcine lymphocytes

Cited by 19 publications

References 34 publications

Immunological Changes Induced in Peach Allergy Patients with Systemic Reactions by Pru p 3 Sublingual Immunotherapy

Immunological Changes Induced in Peach Allergy Patients with Systemic Reactions by Pru p 3 Sublingual Immunotherapy

Porcine Circovirus Type 2 Rep Enhances IL-10 Production in Macrophages via Activation of p38-MAPK Pathway

Co-Infection of Swine with Porcine Circovirus Type 2 and Other Swine Viruses

Contact Info

Product

Resources

About