The PCOS Patients differ in Lipid Profile According to their Phenotypes

Spałkowska, Magdalena; Mrozińska, Sandra; Gałuszka-Bednarczyk, Anna; Gosztyła, Katarzyna; Przywara, Agnieszka; Guzik, Justyna; Janeczko, Marek; Milewicz, Tomasz; Wojas‐Pelc, Anna

doi:10.1055/s-0043-121264

Cited by 23 publications

(13 citation statements)

References 37 publications

(48 reference statements)

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“…Consistent with our findings, the disturbed hormonal profile in PCOS group could lead to hypercholesterolemia and hypertriglyceridemia as proposed by Pan et al [ 23 ] and Spałkowska et al [ 32 ] who suggested that hyperandrogenism is a leading cause of abnormal lipid profile. SLE-treated animals showed a significant reduction in total cholesterol and TGs with equal efficacy compared to metformin treatment.…”

Section: Discussionsupporting

confidence: 92%

Histomorphological Changes in a Rat Model of Polycystic Ovary Syndrome and the Contribution of Stevia Leaf Extract in Modulating the Ovarian Fibrosis, VEGF, and TGF-β Immunoexpressions: Comparison with Metformin

Morsi

Mersal

Farrag

et al. 2022

Acta Histochem. Cytochem.

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Polycystic ovary syndrome (PCOS) is a common endocrine disorder of fertile females. It has been reported that stevia leaf extract (SLE) has antidiabetic and antihyperlipidemic properties. Therefore, the current study hypothesized and investigated the role and mechanistic aspects of a natural sweetener; SLE in treating a rat model of letrozole-induced PCOS and to compare it with metformin. Thirty-five female Wistar albino rats were divided into 5 groups: control, PCOS-induced group (letrozole, 1 mg/kg/d, for 21 days), SLE, metformin, and combination-treated groups (300 mg/kg/d, for the next 28 days in SLE and metformintreated groups). Vaginal smears were done. The levels of glucose, lipid, and hormonal profiles were measured in the serum meanwhile, malonyl dialdehyde (MDA), superoxide dismutase (SOD), and tumour necrosis factor (TNF-α) were measured in the ovary. Ovarian sections were subjected to hematoxylin and eosin, Masson, and immunohistochemical identification of VEGF and TGF-β followed by morphometric analysis. PCOS rats showed altered hormonal and lipid profiles, in addition to hyperglycemia. Also, the ovarian tissue levels of MDA and TNF-α were elevated, and SOD was decreased. Numerous cystic follicles, decrease/absence of corpora lutea, interstitial fibrosis with positive VEGF and TGF-β immunoreactivity were evident. SLE improved all altered parameters. SLE showed potential therapeutic merits in letrozole-induced PCOS via anti-inflammatory, antioxidant, anti-fibrotic, and angiogenesis regulating mechanisms. Its effects were almost comparable to metformin, and the combination of both has no further synergistic effect.

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Section: Discussionsupporting

confidence: 92%

Histomorphological Changes in a Rat Model of Polycystic Ovary Syndrome and the Contribution of Stevia Leaf Extract in Modulating the Ovarian Fibrosis, VEGF, and TGF-β Immunoexpressions: Comparison with Metformin

Morsi

Mersal

Farrag

et al. 2022

Acta Histochem. Cytochem.

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“…In accordance with this, we found that a high FG‐score was associated with lower SES; however, this association did not remain significant in logistic regression analyses. It is possible that lean women with PCOS represent a separate PCOS phenotype and metabolic risk in lean women with PCOS could be determined primarily by hyperandrogenism . The present study design did not allow us to compare SES in lean women with PCOS with lean controls.…”

Section: Discussionmentioning

confidence: 93%

Socioeconomic status in Danish women with polycystic ovary syndrome: A register‐based cohort study

Rubin

Andersen

Abrahamsen

et al. 2018

Acta Obstet Gynecol Scand

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| INTRODUC TI ONPolycystic ovary syndrome (PCOS) can be diagnosed in around 10% of premenopausal women. 1,2 PCOS is characterized by irregular menses, polycystic ovaries and hyperandrogenism. 1 Quality of life may be impaired in PCOS and the risk of depression and development of medical and psychiatric diseases is increased. 3,4 More than 50% women with PCOS are obese. 5 Obesity is associated with a more severe PCOS phenotype including more irregular menses, infertility and hirsutism, 6,7 and obesity is associated with impaired quality of life and depression in PCOS. 8,9 In the general population, Newton et al reported a consistent association between lower life course socioeconomic status (SES) and obesity among Abstract Introduction: Low socioeconomic status (SES) may be associated with increased risk of polycystic ovary syndrome (PCOS) and vice versa. Possible associations between SES, obesity and ethnicity in PCOS are undetermined. Material and methods: National register-based study including women with PCOS aged 25 years or above (PCOS Denmark and an embedded cohort; PCOS Odense University Hospital [OUH]) and one control population. PCOS Denmark (n = 13 891) included women with PCOS in the Danish National Patient Register. Women in PCOS OUH underwent clinical examination (n = 814). Three age-matched controls were included per patient (n = 41 584). The main outcome measure was SES (personal income, occupational status and education).Results: The median (Q1; Q3) age of women in PCOS Denmark and controls was 33 (29; 39) years. Women with personal income in the lower tertile had a higher probability of a PCOS diagnosis than women in the high-income tertile (adjusted odds ratio[aOR] 1.5, 95% confidence interval [CI] 1.4-1.6). Women who were unemployed or on welfare payment (aOR 1.5, 95% CI 1.4-1.6), or who retired early (OR 1.8, 95% CI 1.7-2.0) had a higher probability of a PCOS diagnosis than women affiliated to the labor market. Women originating from the Middle East more often had PCOS (aOR 3.2, 95% CI 2.8-3.7) compared with women originating from Europe. In PCOS OUH, SES was lower in obese than in normal weight women.Conclusions: A diagnosis of PCOS was associated with lower SES. In PCOS, women of foreign origin and women with obesity more often had low SES. K E Y W O R D Sethnicity, nationwide, polycystic ovary syndrome, register-based, socioeconomic status | 441 RUBIN et al.

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“…But another researcher who assessed the lipid profile in lean and non-lean PCOS patients, hyperandrogenemia was defined as free androgen index (FAI) ≥5, whose results show higher levels of total cholesterol, high-density lipoprotein cholesterol in lean patients with FAI <5 than in lean patients with FAI ≥ 5. There were no differences in lipid profile between non-lean patients with FAI ≥ 5 and non-lean patients with FAI <5 4 . Another study has also confirmed these results with Ferriman-Gallwey scores(FGS) and triglycerides are significantly higher in PCOS patients 5 .…”

mentioning

confidence: 73%

Triglycerides, independent of Ferriman Gallwey Score, is a main determinant of free testosterone index in PCOS

et al. 2019

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Background: Polycystic Ovarian Syndrome (PCOS) is the most common endocrinopathy in women of reproductive age, affecting 5-20% of women worldwide. Hyperandrogenism, as the primary characteristic of PCOS, is not always present in every patient. The hyperandrogenic phenotype of PCOS patients is influenced by both hormonal and metabolic dysfunctions. Therefore, this study aims to determine the correlation between hormone profile, lipid profile, and clinical profile with free testosterone index in subjects with PCOS. Methods: This prospective cross-sectional study was conducted in the Dr. Cipto Mangunkusumo General Hospital between July 2014 and December 2016. The study involved 76 women with PCOS, who were classified into 2 subgroups: 39 subjects in the hyperandrogenism group and 37 subjects in the non-hyperandrogenism group. Each subject underwent physical examination, blood sample collection, and USG examination. Bivariate analysis was done using independent t-tests and Mann Whitney U-tests, while multivariate analysis was done using logistic regression. Results: Triglyceride and testosterone level showed weak (r = 0.232, p = 0.044) and moderate (r = 0.460, p ¡ 0.001) positive correlation with FTI, while SHBG level showed moderate negative correlation (r = -0.483, p ¡ 0.001). Triglyceride was also found to be determinant of hyperandrogenism condition in PCOS patient (OR 0.02, 95% CI 0.00–0.04, p = 0.013). However, there was no significant difference observed between FGS and hyperandrogenism (p = 0.43). Conclusions: Triglycerides, testosterone, and SHBG were associated with hyperandrogenism in PCOS patients, while FGS showed no such association.

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The PCOS Patients differ in Lipid Profile According to their Phenotypes

Abstract: The results of our study showed differences in lipid profile between lean PCOS patients according to their phenotype based on androgens' level. This effect was abandoned by fat tissue mass in non-lean ones. Further studies should be conducted to explore these associations.

Cited by 23 publications

References 37 publications

Histomorphological Changes in a Rat Model of Polycystic Ovary Syndrome and the Contribution of Stevia Leaf Extract in Modulating the Ovarian Fibrosis, VEGF, and TGF-β Immunoexpressions: Comparison with Metformin

Histomorphological Changes in a Rat Model of Polycystic Ovary Syndrome and the Contribution of Stevia Leaf Extract in Modulating the Ovarian Fibrosis, VEGF, and TGF-β Immunoexpressions: Comparison with Metformin

Socioeconomic status in Danish women with polycystic ovary syndrome: A register‐based cohort study

Triglycerides, independent of Ferriman Gallwey Score, is a main determinant of free testosterone index in PCOS

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