The pCONus2 Neck-Bridging Device: Early Clinical Experience and Immediate Angiographic Results

Lylyk, Pedro; Chudyk, Jorge; Bleise, Carlos; Sahl, Harald; Pérez, Marta Aguilar; Henkes, Hans; Bhogal, Pervinder

doi:10.1016/j.wneu.2017.11.097

Cited by 32 publications

(17 citation statements)

References 24 publications

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“…In angiographic follow-up (mean=4.6 months, range=3–6 months), adequate aneurysm occlusion was observed in 83% (5/6) and aneurysm recanalisation in 17% (1/6). The use of pCONus 2 did not result in any haemorrhagic complications or death 39…”

Section: Advances In Stent-assisted Coilingmentioning

confidence: 81%

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Advances in endovascular aneurysm management: coiling and adjunctive devices

et al. 2020

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Endovascular coil embolisation continues to evolve and remains a valid modality in managing ruptured and unruptured cerebral aneurysms. Technological advances in coil properties, adjunctive devices and interventional techniques continue to improve long-term aneurysm occlusion rates. This review elaborates on the latest advances in next-generation endovascular coils and adjunctive coiling techniques for treating cerebral aneurysms.on June 9, 2020 by guest. Protected by copyright.

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Section: Advances In Stent-assisted Coilingmentioning

confidence: 81%

“…It is compatible with 0.021-inch diameter microcatheters. This device is currently approved for use in Europe but not in the USA by the FDA 38 39. The distal portion of stent consists of six polyamide fibres that cross and provide additional support to the coil ball in the aneurysm.…”

Section: Advances In Stent-assisted Coilingmentioning

confidence: 99%

Advances in endovascular aneurysm management: coiling and adjunctive devices

et al. 2020

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“…A variety of techniques have been developed to deal with difficult aneurysmal morphology including balloon remodelling, waffle-cone stenting, Y-stenting and T-stenting. Recently, numerous dedicated devices have entered the market which have been designed to tackle this difficult entity and they include the pCONUS 1, pCONUS 2 [ 11 ], pCANvas [ 12 ] (Phenox, Bochum, Germany), the PulseRider [ 13 ] (Pulsar Vascular, Los Gatos, California, USA), the Barrel vascular reconstruction device (Medtronic, Dublin, Ireland) and the eCLIPs device [ 14 ] (Evasc Medical Systems Corp.). These devices share the common feature of providing extra coverage at the aneurysm neck to prevent coil prolapse into the parent vessel.…”

Section: Introductionmentioning

confidence: 99%

The pCONUS HPC: 30-Day and 180-Day In Vivo Biocompatibility Results

Bhogal

Lenz-Habijan

Bannewitz

et al. 2019

Cardiovasc Intervent Radiol

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Background Endovascular stents are commonly used during neurointerventional procedures; however, the concomitant use of dual anti-platelet treatment (DAPT) can limit their use. There is a need to develop stent coatings that mitigate requirement for DAPT. Methods The hydrophilic polymer coating is a novel glycan-based multilayer polymer that inhibits platelet adhesion. After Institutional Animal Care and Use Committee approval, 18 New Zealand white rabbits (mean weight 4.02 ± 0.51 kg) were commenced on DAPT (ASA 10 mg/kg/day and clopidogrel 10 mg/kg/day). A bare nitinol pCONUS and coated pCONUS HPC were implanted into the common carotid arteries of each rabbit. Histological examinations were performed at 30 days ( n = 9) and 180 days ( n = 8) to assess the acute and chronic inflammatory reactions to the pCONUS HPC. Wilcoxon/Kruskal–Wallis and ANOVA were used with p value < 0.05 considered as significant. Results There is no statistically significant difference in inflammation within the intima/media or adventitia at 30 days ( p = 0.3901 and p = 1, respectively) or at 180 days ( p = 0.144 and p = 1, respectively) between pCONUS and pCONUS HPC cohorts. There is no significant difference in the presence of granulomas or giant cells between the cohorts at either 30 days ( p = 1 and p = 0.8363) or 180 days ( p = 1.00 and p = 0.149). At 30 days and 180 days, there was near-complete endothelialisation of the stent struts and no significant difference between the pCONUS or pCONUS HPC ( p = 0.7832 and p = 0.334, respectively). Conclusion pCONUS HPC stents do not elicit an acute or chronic inflammatory response in vivo with no significant difference in the tissue response to bare nitinol pCONUS stents or pCONUS HPC stents.

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“…The whole system is fully deployable and retrievable and is electrolytically detached. The second-generation pCONus2 device features further design improvements aimed at improving functionality and ease of use (Lylyk et al 2018). The newer device is also a laser-cut stent with a distal crown but without polyamide fibers; rather, the crowns emanate from a central spur.…”

Section: Discussionmentioning

confidence: 99%

Anterior Communicating Artery Aneurysm: Ruptured Wide-Necked Anterior Communicating Artery Aneurysm Incorporating Both A2 Anterior Cerebral Arteries; Staged Treatment with “Protective” Partial Coiling in the Acute Phase; and Definitive Treatment 2 Years Later with pCONUS1-Assisted Coiling, Achieving Complete and Permanent Aneurysm Occlusion

Cohen¹

2020

The Aneurysm Casebook

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Anterior communicating artery (AcomA) aneurysms are among the most challenging aneurysms for both microsurgical clipping and endovascular techniques. AcomA aneurysms frequently have a wide neck and irregular shape. They incorporate afferent and efferent vessels and are often associated with significant variations in vascular anatomy. Safe and complete endovascular coil occlusion of these aneurysms may require the assistance of a compliant balloon or a self-expanding stent, according to an individual treatment strategy. A 53-year-old male patient presented with sudden-onset severe headaches, vomiting, and alternating sensorium, leading to coma. He was intubated upon admission to the emergency room. Noncontrast cranial CT showed a thick symmetric, diffuse, non-lateralizing basal

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The pCONus2 Neck-Bridging Device: Early Clinical Experience and Immediate Angiographic Results

Abstract: The early results on the use of the pCONus2 device suggest that it can be useful for treating wide-necked aneurysms; however, larger studies with longer-term follow-up data are needed.

Cited by 32 publications

References 24 publications

Advances in endovascular aneurysm management: coiling and adjunctive devices

Advances in endovascular aneurysm management: coiling and adjunctive devices

The pCONUS HPC: 30-Day and 180-Day In Vivo Biocompatibility Results

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