The Pax protein Eyegone (Eyg) interacts with the pi-RNA component Aubergine (Aub) and controls egg chamber development in Drosophila

Blom-Dahl, David; Azpiazu, Natalia

doi:10.1016/j.ydbio.2017.12.012

Cited by 4 publications

(3 citation statements)

References 35 publications

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“…In addition, the appearance of mitotic defects, increased expression of retrotransposons and alterations in H3 phosphorylation observed in early blastoderms derived from sal heterozygous flies suggest a role for Salm/Salr in the initial establishment of centromeric heterochromatin regions. Other Drosophila transcription factors, such as Eyegone (Eyg) and Homothorax (Hth) have been shown to participate in the regulation of heterochromatic assembly in early Drosophila blastoderms (Hth; Salvany et al, 2009; Zaballos et al, 2015) or in heterochromatic gene silencing (Eyg; Salvany et al, 2012; Blom-Dahl and Azpiazu, 2018). In the case of Hth, it has been proposed that maternal Hth contributes to the transcription of satellite repeats, whereas Eyg interacts with HP1 to maintain a closed heterochromatin-like conformation (Salvany et al 2012, 2009).…”

Section: Discussionmentioning

confidence: 99%

A function of Spalt proteins in heterochromatin organization and maintenance of genomic DNA integrity

Ostalé,

Azpiazu,

Peropadre

et al. 2024

Preprint

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The phylogenetically conserved Spalt proteins regulate gene expression and participate in a variety of cell fate choices during multicellular development, generally acting as transcriptional repressors in different gene regulatory networks. Paradoxically, besides their roles as DNA sequence-specific transcription factors, Spalt proteins show a consistent localization to heterochromatic regions. They can act through interactions with the Nucleosome remodeling and deacetylase complex (NuRD) to promote closing of open chromatin domains, but their activities as epigenetic regulators also rely on interactions with DNA Methyltransferases or with the Lysine-specific histone demethylase LSD1, suggesting that they can participate in multiple regulatory mechanisms. Here we describe several major consequences of loss of spalt function in Drosophila cells, including changes in chromatin accessibility affecting mostly pericentromeric heterochromatin, the generation of DNA damage, alterations in the localization of chromosomes within the nucleus in polyploid cells of the salivary glands and miss-expression of transposable elements. We suggest that most of these effects are related to roles of Spalt proteins in the regulation of heterochromatin formation. We propose that Drosophila Spalt proteins have two complementary functions, acting as sequence-specific transcriptional repressors on specific target genes and regulating more global gene silencing through the generation or maintenance of heterochromatic domains.

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Section: Discussionmentioning

confidence: 99%

A function of Spalt proteins in heterochromatin organization and maintenance of genomic DNA integrity

Ostalé,

Azpiazu,

Peropadre

et al. 2024

Preprint

Self Cite

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“…Furthermore, snoRNAs represent an emerging field of cancer research and promising tools as clinical prognostic and diagnostic biomarkers for cancer . Pi-RNA, a promising and young class of small ncRNA, is generally distributed in germline stem cells. , More than 30,000 pi-RNAs have been found in humans . pi-RNAs can form the pi-RISC via binding to the PIWI protein, and they regulate gene-silencing signaling pathways in transcription, post-transcription and epigenetics .…”

Section: Micrornasmentioning

confidence: 99%

The Role of microRNAs in Arsenic-Induced Human Diseases: A Review

Liu,

Lei

2023

J. Agric. Food Chem.

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MicroRNAs (miRNAs) are noncoding RNAs with 20–22 nucleotides, which are encoded by endogenous genes and are capable of targeting the majority of human mRNAs. Arsenic is regarded as a human carcinogen, which can lead to many adverse health effects including diabetes, skin lesions, kidney disease, neurological impairment, male reproductive injury, and cardiovascular disease (CVD) such as cardiac arrhythmias, ischemic heart failure, and endothelial dysfunction. miRNAs can act as tumor suppressors and oncogenes via directly targeting oncogenes or tumor suppressors. Recently, miRNA dysregulation was considered to be an important mechanism of arsenic-induced human diseases and a potential biomarker to predict the diseases caused by arsenic exposure. Endogenic miRNAs such as miR-21, the miR-200 family, miR-155, and the let-7 family are involved in arsenic-induced human disease by inducing translational repression or RNA degradation and influencing multiple pathways, including mTOR/Arg 1, HIF-1α/VEGF, AKT, c-Myc, MAPK, Wnt, and PI3K pathways. Additionally, exogenous miRNAs derived from plants, such as miR-34a, miR-159, miR-2911, miR-159a, miR-156c, miR-168, etc., among others, can be transported from blood to specific tissue/organ systems in vivo. These exogenous miRNAs might be critical players in the treatment of human diseases by regulating host gene expression. This review summarizes the regulatory mechanisms of miRNAs in arsenic-induced human diseases, including cancers, CVD, and other human diseases. These special miRNAs could serve as potential biomarkers in the management and treatment of human diseases linked to arsenic exposure. Finally, the protective action of exogenous miRNAs, including antitumor, anti-inflammatory, anti-CVD, antioxidant stress, and antivirus are described.

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“…Nuclear pre-snRNA exportation is a critical quality control mechanism for functional spliceosomes and is involved in RNA processing (Becker et al 2019 ). pi-RNA also is a class of RNA that interacts with the Piwi protein, which is commonly found in germline stem cells (Blom-Dahl and Azpiazu 2018 ). It shows a distinctive localization type in the genome and plays an important role in the maintenance of stem cell function, gamete formation, and silencing of foreign transposons (Czech et al 2018 ).…”

Section: Small Non-coding Rnamentioning

confidence: 99%

The role of microRNAs in neurodegenerative diseases: a review

Lei

Sun

2022

Cell Biol Toxicol

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MicroRNAs (miRNAs) are non-coding RNAs which are essential post-transcriptional gene regulators in various neuronal degenerative diseases and playact a key role in these physiological progresses. Neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, multiple sclerosis, and, stroke, are seriously threats to the life and health of all human health and life kind. Recently, various studies have reported that some various miRNAs can regulate the development of neurodegenerative diseases as well as act as biomarkers to predict these neuronal diseases conditions. Endogenic miRNAs such as miR-9, the miR-29 family, miR-15, and the miR-34 family are generally dysregulated in animal and cell models. They are involved in regulating the physiological and biochemical processes in the nervous system by targeting regulating different molecular targets and influencing a variety of pathways. Additionally, exogenous miRNAs derived from homologous plants and defined as botanmin, such as miR2911 and miR168, can be taken up and transferred by other species to be and then act analogously to endogenic miRNAs to regulate the physiological and biochemical processes. This review summarizes the mechanism and principle of miRNAs in the treatment of some neurodegenerative diseases, as well as discusses several types of miRNAs which were the most commonly reported in diseases. These miRNAs could serve as a study provided some potential biomarkers in neurodegenerative diseases might be an ideal and/or therapeutic targets for neurodegenerative diseases. Finally, the role accounted of the prospective exogenous miRNAs involved in mammalian diseases is described. Graphical abstract 1. Listing a large number of neural-related miRNAs and sorting out their pathways. 2. Classify and sort miRNAs according to their mechanism of action. 3. Demonstrating the effects of up-regulation or down-regulation of each miRNAs on the nervous system.

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The Pax protein Eyegone (Eyg) interacts with the pi-RNA component Aubergine (Aub) and controls egg chamber development in Drosophila

Cited by 4 publications

References 35 publications

A function of Spalt proteins in heterochromatin organization and maintenance of genomic DNA integrity

A function of Spalt proteins in heterochromatin organization and maintenance of genomic DNA integrity

The Role of microRNAs in Arsenic-Induced Human Diseases: A Review

The role of microRNAs in neurodegenerative diseases: a review

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