The patterns of left ventricular alteration by adipose tissue distribution: implication for heart failure prevention

Abstract

Aims The current study aimed to evaluate the associations between general and abdominal obesity with left ventricular (LV) structure and function and whether these associations differed by sex. Methods and results This is a community-based cross-sectional study, and 971 hypertensive individuals without overt cardiovascular disease were included. General obesity was defined as body mass index (BMI) ≥ 28 kg/m 2 , and abdominal obesity was defined as waist circumference (WC) ≥ 90 cm for men and ≥85 cm for women. The associations between general and abdominal obesity with LV structure and function were examined using linear regression analysis, and the interaction by sex was performed. The mean age was 66.5 ± 11.4 years, and women accounted for 62%. General obese individuals (n = 205) were more likely to have concentric remodelling, LV hypertrophy, and worse diastolic function. Similar differences were observed in abdominal obese individuals (n = 593). General obesity was associated with LV end-diastolic volume, LV mass, left atrial volume, and septal E/e' ratio after adjusting for WC and clinical covariates; and abdominal obesity was associated with septal e' velocity after adjusting for BMI and clinical covariates. The associations between general obesity with LV structure and function did not differ by sex, while the magnitudes of the associations between abdominal obesity with LV mass and septal e' velocity were greater in men. Conclusions General and abdominal obesity were associated with different patterns of LV structural and functional alterations, stressing the importance of incorporating BMI and WC measurements into assessing obesity-related LV alterations.

Prognostic implications of left ventricular hypertrophy defined by the thresholds from the international and Chinese guidelines

“…This was a community‐based cohort study conducted in Liao Bu County, Dongguan, Guangdong Province, China, as previously reported 11,12 . During the annual health examination sponsored by government in 2014, a total of 2499 hypertensive patients had echocardiographic examination.…”

“…This was a community‐based cohort study conducted in Liao Bu County, Dongguan, Guangdong Province, China, as previously reported. 11 , 12 During the annual health examination sponsored by government in 2014, a total of 2499 hypertensive patients had echocardiographic examination. Hypertension was defined as systolic blood pressure (SBP) ≥140 mmHg or diastolic blood pressure (DBP) ≥90 mmHg and/or the use of antihypertensive medicine within 2 weeks.…”

Longitudinal Study of Left Ventricular Mass Index Trajectories and Risk of Mortality in Hypertension: A Cohort Study

“…As previously reported, the study was an observational cohort study and was conducted in Liao Bu County, Dongguan, Guangdong Province, China. 11 , 12 Government‐sponsored annual health examinations have been conducted since 2010. For individuals with hypertension, we would conduct the echocardiographic examination during annual health examinations in round 1 (2010–2012), round 2 (2013–2014), and round 3 (2015–2016) (Figure 1 ).…”

The Influence of Pericardial Fat on Left Ventricular Diastolic Function

“…The study explains that this relationship is due to the predisposition of these individuals to have greater blood volume because of the higher metabolic demand they face. This, in turn, leads to a greater cardiac output [34]. The increase in ventricular mass occurs as a result of the need to compensate for underlying hemodynamic changes, an increase in LV volume due to an increase in afterload, and as an adaptive mechanism in the face of changes in diastolic function.…”