The Pattern of Uveitis in a Pediatric Population at a Tertiary Center in Thailand

Seepongphun, Usanee; Sittivarakul, Wantanee; Dangboon, Wantanee; Sangthong, Rassamee

doi:10.1080/09273948.2021.1980814

Cited by 6 publications

(8 citation statements)

References 38 publications

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“…Our study demonstrated that the incidence and prevalence of pediatric uveitis were higher in the 13–18 years age group than in the 0–6 years age group. The increase in the detection rate by age was also observed not only in other epidemiologic studies concerning pediatric uveitis, 13 14 15 but also in the epidemiologic study of all-age uveitis conducted in Korea. 12 This could be attributed to the challenges in reporting symptoms and performing comprehensive eye examinations in younger patients.…”

Section: Discussionsupporting

confidence: 63%

Incidence and Prevalence of Pediatric Noninfectious Uveitis in Korea: A Population-Based Study

Kim

Chang

Lee³

et al. 2022

J Korean Med Sci

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Background Uveitis is less common in children than in adults; however, pediatric uveitis has a relatively severe disease course that affects the quality of life. Although it is important to understand the epidemiological characteristics of pediatric uveitis, few studies have been conducted in large populations without referral bias. This study investigated the nationwide incidence and prevalence of pediatric uveitis in South Korea according to period, age, anatomic type, and systemic associations. Methods This nationwide population-based cohort study used data from the Korean National Health Insurance Service from 2002 to 2018. This study included patients younger than 19 years of age with noninfectious uveitis with at least three claims of diagnostic codes of uveitis on separate days with at least once claim of prescription codes of steroid and immunosuppressive agents. All the cases were classified as anterior or non-anterior uveitis, and the overall incidence and prevalence were estimated by age, sex, and period. Patients with noninfectious uveitis were categorized by the presence of associated systemic conditions. Results A total of 10,862,616 patients over 128,688,078 person-years were evaluated from 2005 to 2016. Overall, 5,368 cases of anterior uveitis and 604 cases of non-anterior uveitis were identified. The incidence and prevalence of pediatric noninfectious uveitis were 4.64 per 100,000 person-years (95% confidence interval [CI], 4.52–4.76) and 8.25 per 100,000 persons (95% CI, 8.09–8.41). Both the incidence and prevalence of pediatric uveitis increased with age. Anterior uveitis accounted for 84.7% of pediatric noninfectious uveitis prevalent cases (6.99 per 100,000 persons). Cases of juvenile idiopathic arthritis (JIA)-associated uveitis accounted for 8.7% (926 cases) of pediatric noninfectious uveitis cases with a prevalence of 0.72 per 100,000 (95% CI, 0.67–0.77). The proportion of systemic associations was higher and JIA-related uveitis accounted for 11.2% (803 cases) of recurrent or chronic noninfectious uveitis cases with a prevalence of 0.62 per 100,000. Conclusion This is the first population-based study investigating the largest population of pediatric patients with uveitis in Korea. The nationwide incidence and prevalence of pediatric noninfectious uveitis in 2005–2016 were 4.64 per 100,000 person-years and 8.25 per 100,000, respectively. The proportion of JIA in pediatric noninfectious uveitis was 8.7%. These population-based study findings provide a better understanding of the public health burden and aid in the planning of health-care strategies for pediatric patients with uveitis.

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Section: Discussionsupporting

confidence: 63%

Incidence and Prevalence of Pediatric Noninfectious Uveitis in Korea: A Population-Based Study

Kim

Chang

Lee³

et al. 2022

J Korean Med Sci

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“…Our previous study demonstrated that approximately 40% of eyes of children with uveitis suffered severe visual impairment (SVI), defined as VA ≤ 20/200, at first presentation. Additionally, SVI at presentation was the only predictive factor of poor VA outcome at 1 year after presentation to our tertiary center 12 . However, the long-term pattern of VA outcome in pediatric patients with uveitis who presented initially with SVI is not well characterized.…”

Section: Introductionmentioning

confidence: 77%

“…Furthermore, JIA-associated uveitis, which accounts for most pediatric patients with uveitis in Western countries, is a rare entity in Thailand and in Southeast Asia in general. The prevalence of JIA-associated uveitis reported from this region ranges from 0 to 1.5% 12 , 28 – 33 . Our previous publication on the pattern of pediatric uveitis that included all pediatric patients from 2010 to 2020 had identified JIA-associated uveitis in only two of 118 (1.7%) children and none of them had presenting VA of ≤ 20/200 12 .…”

Section: Discussionmentioning

confidence: 95%

“…The prevalence of JIA-associated uveitis reported from this region ranges from 0 to 1.5% 12 , 28 – 33 . Our previous publication on the pattern of pediatric uveitis that included all pediatric patients from 2010 to 2020 had identified JIA-associated uveitis in only two of 118 (1.7%) children and none of them had presenting VA of ≤ 20/200 12 . Hence, there were no children with JIA-associated uveitis enrolled in the present study.…”

Section: Discussionmentioning

confidence: 95%

“…Children with a follow-up period of less than 6 months, who could not undergo VA assessment, or who did not have VA data for the first visit were also excluded. Details of the study population have been described in our previous study 12 . The Ethics Committee of the Faculty of Medicine, Prince of Songkla University approved this study (no.…”

Section: Methodsmentioning

confidence: 99%

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Long-term visual acuity outcome of pediatric uveitis patients presenting with severe visual impairment

Tungsattayathitthan

Rattanalert

Sittivarakul

2023

Sci Rep

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This study investigated the long-term visual acuity (VA) outcome in the eyes of children with uveitis and severe visual impairment (SVI; VA ≤ 20/200) at presentation. Fifty-one children [57 eyes; median age, 11 years; 51% female; median follow-up period, 36 months (interquartile range 14.9–64.4)] aged ≤ 16 years with uveitis managed at our tertiary center from January 2010 to July 2020 were reviewed. Uveitis mainly manifested as unilateral (74.5%), chronic course (82.4%), and panuveitis (43.1%). Ocular toxoplasmosis and toxocariasis were the most common diagnoses (9.8% each). At least one ocular complication at presentation was observed in 93% of the eyes. Overall, the mean logMAR VA improved from 1.8 at presentation to 1.2 at 5 years (P < 0.001). Common causes of poor vision included retinal detachment, atrophic bulbi, and optic atrophy. Predictive factors associated with less VA improvement over the follow-up period included preschool age of uveitis onset (P < 0.001), ocular symptoms duration before uveitis diagnosis ≥ 1 month (P = 0.004), and non-anterior uveitis (P = 0.047). The long-term VA outcome in uveitis-affected eyes with SVI at presentation was unfavorable. Younger age at uveitis onset, delayed presentation, and uveitis involving the posterior segment were associated with poorer VA outcome.

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Prevalence of Ocular Toxoplasmosis in the General Population and Uveitis Patients: A Systematic Review and Meta-Analysis

Karami

Gorgani-Firouzjaee

Rostami-Mansour

et al. 2023

Ocular Immunology and Inflammation

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The Pattern of Uveitis in a Pediatric Population at a Tertiary Center in Thailand

Cited by 6 publications

References 38 publications

Incidence and Prevalence of Pediatric Noninfectious Uveitis in Korea: A Population-Based Study

Incidence and Prevalence of Pediatric Noninfectious Uveitis in Korea: A Population-Based Study

Long-term visual acuity outcome of pediatric uveitis patients presenting with severe visual impairment

Prevalence of Ocular Toxoplasmosis in the General Population and Uveitis Patients: A Systematic Review and Meta-Analysis

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