The pattern of sesame sensitivity among infants and children

Dalal, Ilan; Binson, Inga; Levine, Arie; Somekh, Eli; Ballin, Ami; Reifen, Ram

doi:10.1034/j.1399-3038.2003.00040.x

Cited by 55 publications

(30 citation statements)

References 11 publications

(14 reference statements)

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“…The present study did not reveal any factors associated with FA, although previous studies have suggested risk factors for the development of FA such as a family history of atopic disease, birth season, and the early ingestion of allergenic foods 6,26,27. However, this study had a limitation in assessing risk factors of FA, because our survey did not include questions on aspects including family history, which is known to be related to atopic diseases.…”

Section: Discussioncontrasting

confidence: 62%

Prevalence of Immediate-Type Food Allergy in Early Childhood in Seoul

Park

Kim

Ahn

et al. 2014

Allergy Asthma Immunol Res

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PurposeThere are scanty epidemiologic data on the prevalence of food allergy (FA) among preschool children in Asia. We performed this study to determine the prevalence and causative foods of immediate-type FA in early childhood in Korea.MethodsA questionnaire-based, cross-sectional study was performed between September and October 2011. Children aged 0-6 years were recruited from 301 public child care centers in Seoul. Parents were asked to complete a questionnaire on FA. Children with FA were classified into "perceived FA, ever," "immediate-type FA, ever," and "immediate-type FA, current" according to the algorithm.ResultsA total of 16,749 children were included in this study. The prevalence of "perceived FA, ever," "immediate-type FA, ever," and "immediate-type FA, current" was 15.1%, 7.0%, and 3.7%, respectively. "Immediate-type FA, current" was reported by 182 (4.9%) out of 3,738 children aged ≤2 years, 262 (3.4%) of 7,648 children aged 3-4 years, and 177 (3.3%) of 5,363 children aged 5-6 years. Hen's egg (126/621) was the most frequent cause as the individual food item, followed by cow's milk (82/621) and peanut (58/621). Among the food groups, fruits (114/621), tree nuts (90/621) and crustaceans (85/621) were the most common offending foods. The three leading causes of food-induced anaphylaxis were hen's egg (22/47), cow's milk (15/47), and peanut (14/47).ConclusionsThe prevalence of immediate-type FA in early childhood is 3.7%, and is higher in younger children. The most common offending foods differed with age.

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Section: Discussioncontrasting

confidence: 62%

Prevalence of Immediate-Type Food Allergy in Early Childhood in Seoul

Park

Kim

Ahn

et al. 2014

Allergy Asthma Immunol Res

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“…There are a few cases in the literature of immediate hypersensitivity to sesame seed with negative skin prick test and/or IgE antibody test results that were confirmed by oral challenge tests [7]. In one study of sesame seed allergy in children, immediate reaction to a minimal amount of sesame was characteristic; skin was the most common site of involvement, followed by respiratory and gastrointestinal systems; tolerance developed in only 20% of the patients, and high sIgE (> 0.15 IU) was demonstrated only in 75% of those in which it was examined [8].…”

Section: Discussionmentioning

confidence: 99%

Food Allergy in Lebanon: Is Sesame Seed the "Middle Eastern" Peanut

Irani

Maalouly

Germanos

et al. 2011

World Allergy Organization Journal

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A randomly sampled, cross-sectional serology test-based survey was conducted in Lebanon to describe the pattern of food allergy among Lebanese population. The prevalence of specific Immunoglobulin E (IgE) to food allergens was investigated in 20 laboratories in different regions of Lebanon by an immunoblot assay over a 1 year period. Clinical correlation was determined in two university hospitals. There were 1842 patients with suspected IgE-mediated food allergic reactions tested for specific IgE upon their physician's request. Clinical correlation was done in 93 patients. We identified 386 out of 1842 (20.95%) patients with positive specific IgE to food allergens. The clinical presentations were cutaneous, digestive, and anaphylaxis. The major cause of allergy was cow's milk in infants and young children, hazelnut and wheat flour in adults. Although specific IgE to peanut in infants, children, and adults were higher than for sesame, peanut-induced allergic reactions were mild, in contrary to sesame where anaphylaxis was the only clinical manifestation. Recently, sesame has been recognized as an increasingly frequent and potentially severe allergen. Further studies with double-blind, placebo-controlled food challenge are needed to establish the real prevalence of food allergy in Lebanon, and to determine the most common allergens taking in consideration the nutritional habits of our population.

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“…Another study described 9 of 30 children (30%) developing tolerance at an average age of 2.8 years 3. Dalal et al reported anaphylaxis as the presenting symptom in 30% of children with sesame allergy, all occurring in patients less than 1 year of age 4. This is of significant clinical concern in children who are too young to describe their symptoms.…”

Section: Introductionmentioning

confidence: 99%

Sesame allergy: Role of specific IgE and skin-prick testing in predicting food challenge results

Permaul¹,

Stutius²,

Sheehan³

et al. 2009

allergy asthma proc

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INTRODUCTIONSesame seed is an emerging food allergen in the U.S. pediatric population as it becomes more common in the American diet. A recent systematic review of seed allergies described a prevalence of < 1% for sesame allergy as defined by a positive food challenge.1 It has been reported that most patients have sesame allergy before the age of 2 and about 20% of children with clinical allergy eventually develop tolerance.2 Another study described 9 of 30 children (30%) developing tolerance at an average age of 2.8 years.3 Dalal et al. reported anaphylaxis as the presenting symptom in 30% of children with sesame allergy, all occurring in patients less than 1 year of age.4 This is of significant clinical concern in children who are too young to describe their symptoms.Clinical diagnostic tests such as food-specific IgE levels and skin prick test (SPT) results may aid in deciding who will tolerate a food challenge compared to those who are likely to react.5 Diagnostic decision points for food-specific IgE antibodies have been published for common food allergens such as egg, milk, peanut and fish.6 , 7 However, there is conflicting data regarding the diagnostic value of sesame-specific IgE and SPT and currently there are no established thresholds that predict clinical reactivity. Zavalkoff et al. were unable to establish a sesame-specific IgE threshold with a 95% positive predictive value.8 In a paper published by Maloney et al., a fitted predicted probability curve of clinical reactivity to sesame in relation to sesame-specific IgE did not show a 90% or 95% predicted probability of a reaction.9 Lastly, Ho et al. identified a sesame SPT wheal diameter ≥ 8 mm as being predictive of a positive food challenge with > 95% accuracy.10 Oral food challenge was used as the gold standard by which performance characteristics (sensitivity, specificity, positive and negative predictive values) of sesame-specific IgE measurements and SPT wheal size were calculated. Receiver operator characteristic curve (ROC) analysis was utilized to determine a threshold that would differentiate children with true sesame allergy from those who are tolerant. The relationship between sensitization status and outcome measure was analyzed using logistic regression. Fitted predicted probability curves were plotted using the results from logistic regression.Serum samples were analyzed for sesame-specific IgE using an ImmunoCAP fluorescence enzyme immunoassay (Phadia AB, Portage, MI). The detection limit of the assay was 0.35 kU/L. A positive ImmunoCAP test was defined as ≥ 0.35 kU/L.Skin prick tests were performed in a standard fashion using the Multi-Test II device from Alk-Abello (Round Rock, TX) and commercially prepared extract from Greer Laboratories (Lenoir, NC). Negative controls with saline and positive controls with histamine were performed concurrently. The mean of the longest diameter and orthogonal diameter were measured in millimeters at 15 minutes. A positive SPT was defined as a wheal diameter ≥ 3 mm larger than the negative control....

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The pattern of sesame sensitivity among infants and children

Cited by 55 publications

References 11 publications

Prevalence of Immediate-Type Food Allergy in Early Childhood in Seoul

Prevalence of Immediate-Type Food Allergy in Early Childhood in Seoul

Food Allergy in Lebanon: Is Sesame Seed the "Middle Eastern" Peanut

Sesame allergy: Role of specific IgE and skin-prick testing in predicting food challenge results

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