The pattern of intermediary carbohydrate metabolism in Cushing's syndrome

Henneman, Dorothy H.; Bunker, John P.

doi:10.1016/0002-9343(57)90356-x

Cited by 52 publications

(18 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…5 In addition, those patients found to have increased lactate concentrations in association with Cushing's syndrome had concentrations return to normal after subtotal adrenalectomy. Identical letters within columns denote significant differences.…”

Section: Discussionmentioning

confidence: 97%

“…5,6 In some instances, patients receiving glucocorticoids also may have an underlying disease state associated with hypoperfusion and type A hyperlactatemia. Immune-mediated hemolytic anemia is a common disease of dogs requiring high-dose glucocorticoid therapy that also may be associated with hypoperfusion as a result of red blood cell destruction, vomiting, decreased fluid intake, as well as decreased oxygen delivery because of anemia.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Effects of Prednisone on Blood Lactate Concentrations in Healthy Dogs

Boysen

Bozzetti

Rose

et al. 2009

Veterinary Internal Medicne

View full text Add to dashboard Cite

Background: Glucocorticoids affect carbohydrate and lactate metabolism. Hypothesis: Administration of prednisone to healthy dogs will result in clinically relevant hyperlactatemia. Animals: Twelve healthy adult Beagle dogs. Methods: Prospective, controlled experimental study. Twelve healthy adult Beagles were divided into 2 groups (3 of each sex per group). One group served as control. The other group received 2 treatments: low, 1 mg/kg prednisone PO q24h for 2 weeks; high, 4 mg/kg prednisone PO q24h for 2 weeks. A washout period of 6 weeks separated the treatments. Blood samples were drawn for whole blood lactate measurement on day (D) 0, D4, and D14 and measured in duplicate.Results: Compared with the control group, low and high groups had significantly higher blood lactate concentrations at D4 and D14. There was no difference at D0. There was no effect of time within the control group. In the low and high groups, blood lactate concentration was increased at D4 and D14 versus D0. Blood lactate concentration was greater in the high group than the low group at D14 only.Conclusions and Clinical Importance: Dogs treated with prednisone experience statistically significant increases in blood lactate concentrations, which can result in type B hyperlactatemia. In such cases, improving tissue perfusion, treatment for the commonest form of hyperlactatemia (type A) would be unnecessary.

show abstract

Section: Discussionmentioning

confidence: 97%

mentioning

confidence: 99%

Effects of Prednisone on Blood Lactate Concentrations in Healthy Dogs

Boysen

Bozzetti

Rose

et al. 2009

Veterinary Internal Medicne

View full text Add to dashboard Cite

show abstract

“…The methods for measurement of blood and urinary glucose, lactic, pyruvic, a-ketoglutaric and citric acids, acetone and total ketones, and inorganic phosphorus have been reported previously (6). In addition, plasma FFA were measured by the method of Davis (7) as modified by Gordon and Cherkes (8).…”

Section: Methodsmentioning

confidence: 99%

Effects of Human Growth Hormone on Levels of Blood and Urinary Carbohydrate and Fat Metabolites in Man *

Henneman¹,

Henneman²

1960

J. Clin. Invest.

Self Cite

113

View full text Add to dashboard Cite

In an accompanying paper (1) human growth hormo.ne (HGH) was reported to have stimulated the rate of linear growth, produced retention of nitrogen, phosphorus, magnesium, calcium, sodium and potassium, and perhaps increased the rate of fat mobilization in ten human subjects. This paper describes the response of blood and urinary levels of fat and carbohydrate intermediary metabolites in seven of these and in one infant with hyperinsulinism.1 Some effects of HGH on carbohydrate and fat metabolism have already been published. Raben and Hollenberg (2) observed a prompt and significant rise in plasma free fatty acids (FFA). Beck, McGarry, Dyrenfurth and Venning (3) reported alterations in glucose tolerance in four of six patients and Ikkos, Luft and Gemzell (4) in two of two patients. Ikkos and associates also observed elevations in ketone bodies in three of four patients. The data to be reported in general confirm these observations and include the simultaneous measurements of blood and urinary glucose, lactate, pyruvate, citrate, a-ketoglutarate, free fatty acids and ketones during short and longterm HGH therapy. MATERIAL AND METHODSThe clinical features of the patients studied are reported elsewhere (1). The subjects include 5 patients with hypopituitarism, 1 patient with obesity on an 800 calorie diet and 1 patient with proven hyperinsulinism (5). All patients were studied under constant conditions.Blood levels of carbohydrate and fat intermediary metabolites were measured 4, 8 and 24 hours after injections of 1.0 to 10.0 mg of acid-soluble HGH (Raben).2 HGH was administered as a single intramuscular injection at 6 a.m. (or beginning of "metabolic day") daily for 2 to 36 days.The methods for measurement of blood and urinary glucose, lactic, pyruvic, a-ketoglutaric and citric acids, acetone and total ketones, and inorganic phosphorus have been reported previously (6). In addition, plasma FFA were measured by the method of Davis (7) as modified by Gordon and Cherkes (8). Balance studies were conducted according to the method of Reifenstein, Albright and Wells (9). RESULTS HGH (1) produced a decrease in blood urea nitrogen (BUN) and urinary nitrogen in 24 to 48 hours which was not apparent within the first four hours after injection. With constant daily HGH injections, nitrogen retention increased for 3 to 5 days, was maximal for 2 weeks, and then decreased to low levels in the fourth and fifth weeks of treatment. If HGH were discontinued for 12 days and then resumed, nitrogen retention was again marked. Other constituents of protoplasm were retained in the relative concentrations characteristic of most tissues.Because of the multiphasic nature of the nitrogen response to HGH the measurements of intermediary metabolites have been separated as follows: the early phase (4 hours to 3 days), as nitrogen retention is developing; the second phase (3 to 15 days) during sustained maximal nitrogen 2 Similar responses were obtained with a procainehydrochloride precipitate of HGH (Raben) (1). This preparation of procaine was ...

show abstract

“…In contrast to an initial glucose to nitrogen ratio of 2.5 in the untreated adrenalectomized group (a ratio which did not change appreciably during the 48-hour period Fig. 11 (Frawley, 1955;Henneman and Bunker, 1957).…”

Section: Increased Glucose Output (Liver)mentioning

confidence: 90%