The pattern of dyslipidaemia and factors associated with elevated levels of non-HDL-cholesterol among patients with type 2 diabetes mellitus in the Ho municipality: A cross sectional study

Lokpo, Sylvester Yao; Laryea, Roger; Osei-Yeboah, James; Owiredu, William K. B. A.; Ephraim, Richard K.D.; Adejumo, Esther Ngozi; Ametepe, Samuel; Appiah, Michael; Peter, Nogo; Affrim, Patrick; Kwadzokpui, Precious Kwablah; Abeka, Ohene  Kweku

doi:10.1016/j.heliyon.2022.e10279

Cited by 7 publications

(10 citation statements)

References 44 publications

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“…Individuals with dyslipidemia are at high risk of developing hypertension, atherosclerosis, and cardiovascular disorders. [13] The relationship between vitamin D deficiency and serum lipid levels has become a research topic worldwide. Several studies have linked vitamin D deficiency to dyslipidemia, and vitamin D supplementation may improve lipid profiles in these populations.…”

Section: Introductionmentioning

confidence: 99%

Investigating the relationship between vitamin-D deficiency and glycemia status and lipid profile in nondiabetics and prediabetics in Saudi population

Atia,

Abdelzaher,

Nassar

et al. 2023

Medicine

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Vitamin D deficiency increases the risk of developing diabetes, dyslipidemia, and other chronic diseases. We aimed to investigate the relationship between vitamin D deficiency, glycemic levels, and lipid profiles in individuals with prediabetes and nondiabetes. This observational cross-sectional study was conducted on 249 adults who were divided into 2 groups based on the American Diabetes Association classification: nondiabetics and prediabetics. The serum vitamin D levels, lipid profiles, fasting blood glucose levels, hemoglobin A1c levels, fasting insulin levels, and insulin resistance (IR) were evaluated. The prevalence of vitamin D deficiency in all participants was 30.9%, and mean vitamin D levels were significantly [P = .0004] lower in prediabetics, who were more common in females. Furthermore, prediabetics had significantly higher serum triglycerides [P = .0006], and significantly lower serum high-density lipoprotein levels [P = .0148] than those nondiabetics. Serum cholesterol and low-density lipoprotein levels did not differ significantly between the 2 groups. 31.4% of all participants were overweight and 40.2% were obese. Furthermore, there was a strong correlation between vitamin D levels and IR and body mass indices ≥ 25 in prediabetics [r = −0.92] [P < .001]. Finally, vitamin D levels had a significant inverse relationship with glycemic parameters and IR, particularly in obese participants, but there was no significant relationship with lipid profile. In conclusion, vitamin D deficiency is common in females, regardless of whether they are prediabetics, but is more prevalent in prediabetics. Vitamin D deficiency is associated with high triglycerides and low high-density lipoprotein levels, but there were no significant changes in total cholesterol or low-density lipoprotein levels. Furthermore, vitamin D levels were negatively correlated with both fasting blood glucose and hemoglobin A1c levels, and its deficiency was strongly associated with IR especially in obese patients despite there being no significant correlation with blood lipids.

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Section: Introductionmentioning

confidence: 99%

Investigating the relationship between vitamin-D deficiency and glycemia status and lipid profile in nondiabetics and prediabetics in Saudi population

Atia,

Abdelzaher,

Nassar

et al. 2023

Medicine

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“…Non‐HDL‐C concentration represents the whole quantity of pro‐atherogenic lipoproteins which contain apolipoprotein B 70 . Recently, it has attracted much attention as a potentially better predictor of CVD rather than other lipid indicators 71 . In this study, non‐HDL‐C was identified as an associated factor with hypertension in the crude models only.…”

Section: Discussionmentioning

confidence: 71%

Association of atherosclerosis indices, serum uric acid to high‐density lipoprotein cholesterol ratio and triglycerides‐glucose index with hypertension: A gender‐disaggregated analysis

Ahari,

Sahranavard,

Mansoori

et al. 2024

J of Clinical Hypertension

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This study assessed the association between atherosclerosis indices, serum uric acid to high‐density lipoprotein cholesterol ratio (UHR) and triglyceride‐glucose (TyG) index and the prevalence of hypertension among MASHAD cohort participants. In this cross‐sectional study, the participants were divided into hypertensive and non‐hypertensive subjects. The atherosclerosis indices, UHR and TyG index of the two groups were compared. Logistic regression analyses were used to determine the associations of these indices with hypertension in both sex. Receiver operating characteristic (ROC) curve analysis was used to establish the cut‐off values for differentiating hypertensive from non‐hypertensive subjects. p‐values < .05 were considered statistically significant. Data related to 9675 subjects (3035 hypertensive and 6640 non‐hypertensive) were analyzed. The mean values of atherosclerosis indices, UHR and TyG index were significantly higher (p < .001) in the hypertensives compared to non‐hypertensives. After adjustment for potential confounders, among men, the TyG index (OR = 1.360; 95% CI: 1.210–1.530; p < .001) remained an independent factor for hypertension. Among women, atherogenic index of plasma (OR = 1.005; 95% CI: 1.002–1.007; p < .001), UHR (OR = 1.043; 95% CI: 1.026–1.060; p < .001) and TyG index (OR = 1.519; 95% CI: 1.376–1.677; p < .001) remained independent factors for hypertension. ROC curve analysis revealed that compare to the other indices, TyG index had a better predictive value for hypertension in both sex, especially in women.

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“…The prevalence rate of low HDL-C ( n =35) ranged from 6.2% in Ghana 42 to 76.5% in Nigeria 26 . The pooled prevalence across studies recorded 43.5% (95% CI: 37.1–50.0) (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Across 21 studies, the prevalence of high LDL-C ranged from 10.0% in Ghana 42 to 83.1% in Nigeria 22 . The overall prevalence of high LDL-C recorded 52.7% (95% CI: 44.2–61.1) (Fig.…”

Section: Resultsmentioning

confidence: 99%

Prevalence of dyslipidemia among persons with type 2 diabetes in Africa: a systematic review and meta-analysis

Ekpor,

Addo-Mensah,

Akyirem

2024

Annals of Medicine &Amp; Surgery

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Background: Dyslipidemia is an established cardiovascular risk factor in persons with type 2 diabetes (T2D), yet the extent to which these conditions co-occur in Africa is unknown. This systematic review and meta-analysis aimed to determine the prevalence of dyslipidemia among persons with T2D in Africa. Methods: Medline, Embase, Global Health, Scopus, and Web of Science were searched on December 5, 2023. This review adhered to the PRISMA guidelines and was prospectively registered on PROSPERO. The prevalence data for dyslipidemia was pooled through a random-effects meta-analysis. We assessed heterogeneity and publication bias using I 2 statistics and Egger’s test, respectively. Results: Our search identified 8035 records, of which 60 articles involving 20,034 individuals with T2D were included in this review. The pooled prevalence of dyslipidemia recorded 38.6% (95% CI: 34.1–43.4) for high TC (≥ 5.2 mmol/L), 52.7% (95% CI: 44.2–61.1) for high LDL-C (≥ 2.6 mmol/L), 43.5% (95% CI: 37.1–50.0) for low HDL-C (< 1.0 mmol/L in men and < 1.3 mmol/L in women), and 37.4% (95% CI: 32.2–42.9) for high TG (≥ 1.7 mmol/L). Subgroup analysis based on gender indicated a notably higher prevalence of dyslipidemia among females compared to males. Conclusion: Dyslipidemia is prevalent among persons with T2D in Africa. This highlights the need for early screening, diagnosis, and management of dyslipidemia to mitigate the risk of cardiovascular complications in this population.

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The pattern of dyslipidaemia and factors associated with elevated levels of non-HDL-cholesterol among patients with type 2 diabetes mellitus in the Ho municipality: A cross sectional study

Cited by 7 publications

References 44 publications

Investigating the relationship between vitamin-D deficiency and glycemia status and lipid profile in nondiabetics and prediabetics in Saudi population

Investigating the relationship between vitamin-D deficiency and glycemia status and lipid profile in nondiabetics and prediabetics in Saudi population

Association of atherosclerosis indices, serum uric acid to high‐density lipoprotein cholesterol ratio and triglycerides‐glucose index with hypertension: A gender‐disaggregated analysis

Prevalence of dyslipidemia among persons with type 2 diabetes in Africa: a systematic review and meta-analysis

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