The Pattern of Distribution of Laminin in Neurogenic Tumors, Granular Cell Tumors, and Nevi of the Oral Mucosa

Abstract

Reibel, J., Wewer, U. & Albrechtsen, R. The. pattern of distribution of laminin in neurogenic tumors, granular cell tumors, and nevi of the oral mucosa. Acta path. microbiol. immunol. xand. Sect. A, 93: 41-47, 1985.Oral tumors of presumably neuroectodermal origin were stained with anti-laminin antibody by a double layered immunofluorescence technique. A marked positive staining for laminin was found in neurofibromas and neurilemmomas although the pattern of laminin distribution was slightly different. Accentuated staining was seen in Verocay bodies. In granular cell myoblastomas (GCM), small groups of tumor cells were encircled by laminin-positive material, whereas individual tumor cells were unstained. In nevi, diffusely spread nevus cells were surrounded by a rim of laminin, whereas when arranged in nests whole groups of cells were encircled by laminin as seen in the GCM. Ordinary oral fibromas included as controls were negative except for the expected positive staining of basement membranes normally occurring in the tissues. Immunohistohcemical demonstration of laminin seems to be a valuable aid in differential diagnosis of soft tissue tumors and may provide useful information about the pathogenesis of various lesions.

Tumors of a Granular Cell Lineage

“…These strings represent a distinct cytoplasmic alignment of lysosomes. This view is supported by ultrastructural findings of aligned membrane-limited and lysosome-containing compartments in granular cells (see matrix proteins, laminin, and collagen IV (Miettinen et al 1984;Reibel et al 1985;Nathrath et al 1986). In some instances, tumor cells are closely associated with small nerves and seem to invade perineural spaces (Altavilla et al 2004).…”

Learning from eponyms: Jose Verocay and Verocay bodies, Antoni A and B areas, Nils Antoni and Schwannomas

“…Possibly the overexpression of laminins causes the alignment of nuclei of cells into a tight pattern of rows separated by acellular material inbetween. [ 3 ] It has been hypothesized that such an arrangement of nuclei may be an adaptive response to maintain cell-cell interaction which may otherwise be disrupted due to increased matrix deposition of laminin and phospholipids like lysophosphatidic acid (LPA) which in vitro has been found to induce cluster formation in Schwann cells. [ 4 ]…”

Dermatofibroma with verocay body-type palisading features and a brief discussion on potential schwannoma mimickers of the skin

“…One histological pattern can be prominent or two or more histological patterns can be combined in the same tumor (composite dermatofibromas). A palisading type is rarely seen (2 in 200 dermatofibromas in one study), and it includes other tumors in the differential diagnosis, also rarely presented on the skin, such as schwannoma ( 2 ). Here, we aim to present a case of this rare dermatofibroma variant and discuss cutaneous tumors with nuclear palisading features resembling Verocay bodies.…”

“…Verocay body is described by rows of elongated palisading nuclei with alternating acellular zones. Laminin overexpression ( 2 ) and increased phospholipid deposition in the cellular matrix ( 3 ) are considered in the pathogenesis. Although it is thought to show neural differentiation and is usually identified in schwannoma, Verocay body-like palisading can be seen in other neoplasms of variable origin.…”