The patients less than 50 years: is there a need to lower the PSA cutoff point?

Hekal, Ihab A.

doi:10.1038/pcan.2008.48

Cited by 10 publications

(9 citation statements)

References 26 publications

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“…On other hand, in another study, coincidence finding between PSA and BMI was observed as direct relation in patients o50 years of age, whereas PSA is o4 ng ml À1 . 16 To alleviate this point, we addressed the standard ageadjusted PSA by Oesterling et al 5 Although among our cases, obese men had a relatively larger prostate (mean ± s.d. ¼ 64.3 ± 4.6 gms) versus nonobese (mean ± s.d.…”

Section: Obesity-psa Relationship Ia Hekal and Ei Ibrahiemmentioning

confidence: 99%

Obesity–PSA relationship: a new formula

Hekal

Ibrahiem

2009

Prostate Cancer Prostatic Dis

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To clinically apply the inverse PSA-body mass index (BMI) correlation and enhance PSA sensitivity in obese cases, a new formula is warranted. An innovated BMI-PSA equation is designed. PSA-BMI adjusted formula (named Hekal's equation): measured total PSA (ng ml À1 ) multiplied by age (years) and divided by BMI of the patient. The formula is applied over a randomly chosen 1000 cases of different PSA, BMI, age and trans-rectal ultrasound biopsy results, the yield of new PSA is correlated with pathology and age-specific PSA adjustment values. Among the 988 cases with complete data, obesity (BMI: 30-35 kg m À2 ) in 236 cases (23.8%) and 79 cases (7.9%) have BMI435 kg m À2 . Mean PSA was 5.8 ng ml À1 (s.d.±8.4 ng ml À1 ). Cases stratified based on their age (every 10 years). The new equation was applied. Obesity is detected in 33.5 and 43.6% of fifth and sixth decade of life respectively (P ¼ 0.02), with low measured PSA values (2.1, 3.8 ng ml À1 , respectively). By such PSA measurement biopsy may be omitted, missing 53.3% of malignant cases. In contrast, PSA adjusted were 4 and 9.3 ng ml À1 within the same group of patients. With such values, the decision of a biopsy could not be missed for the targeted groups. Specificity and sensitivity of adjusted PSA values at cutoff point 4 ng ml À1 was 41.7 and 70%, respectively. Based on our results, the new PSA-BMI adjusted formula is reproducible, easy applied formula. With such a formula the higher sensitivity of PSA in obese patients could be achieved. The misleading low PSA in obese cases in the fifth and sixth decade will be corrected.

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Section: Obesity-psa Relationship Ia Hekal and Ei Ibrahiemmentioning

confidence: 99%

Obesity–PSA relationship: a new formula

Hekal

Ibrahiem

2009

Prostate Cancer Prostatic Dis

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“…[4] Here, the author performed a study to find new adjusted PSA cut-off level based on the metaanalyzed data on diagnostic property of PSA among Thai reports. [2] The data were from the single nation and derived from the same method and standard for laboratory analysis.…”

Section: New Adjusted Cut-off Level For Serum Prostate Specific Antigenmentioning

confidence: 99%

“…[2] Of interest, the derived new cut-off level for PSA, based on calculated point estimation, is equal to that proposed by Hekal. [4] The author hereby proposes a new level of adjusted PSA cut-off value to be 1.88 ng/mL, which is expected to have a very high diagnostic property for screening prostate cancer. Further studies to verify this new proposed adjusted PSA cut off level are suggested.…”

Section: New Adjusted Cut-off Level For Serum Prostate Specific Antigenmentioning

confidence: 99%

New adjusted cut-off level for serum prostate specific antigen

Wiwanitkit¹

2011

Indian J Cancer

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“…Prostate-Specific Antigen (PSA) is a uniquely valid tumor and tissue marker for prostate cancer screening and early detection. The widespread use of serum PSA testing for early prostate cancer detection has increased the proportion of early stage cancer and is at least partially responsible for the recent decrease in prostate cancer mortality rates ( 1 ).…”

Section: Introductionmentioning

confidence: 99%

P085 Preventing unnecessary invasive cancer-diagnostic tests

Pourmand¹

2013

European Urology Supplements

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The patients less than 50 years: is there a need to lower the PSA cutoff point?

Cited by 10 publications

References 26 publications

Obesity–PSA relationship: a new formula

Obesity–PSA relationship: a new formula

New adjusted cut-off level for serum prostate specific antigen

P085 Preventing unnecessary invasive cancer-diagnostic tests

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