The patient's comorbidity burden correlates with the erectile dysfunction severity

Garcı́a-Cruz, E.; Carrión, Albert; Ajami, Tarek; Álvarez, Marta Neira; Correas, M.; García, B.; Garcia, Juliana; González, Carlos; Portillo, J.A.; Romero‐Otero, Javier; Simon, Chantal; Torremadé, J.; Vigués, F.; Alcaraz, Antonio

doi:10.1016/j.acuroe.2017.03.012

Cited by 5 publications

(2 citation statements)

References 35 publications

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“…To begin with, a variety of hormones are metabolized and excreted in the kidneys [ 10 , 11 ], in which the diseased kidneys result in abnormal hormone regulations, even leading to a disruption of the hypothalamic-pituitary-gonadal axis [ 38 ]. Next, diabetes, hypertension and atherosclerosis are common comorbidities found in patients with CKDs, of which the cumulative effect leads to a further reduction in their testosterone level [ 39 ]. Finally, CKDs are diseases of inflammation with a negative correlation with circulating testosterone and gradually enhanced as CKDs progress [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Low Testosterone Level and Risk of Adverse Clinical Events among Male Patients with Chronic Kidney Disease: A Systematic Review and Meta-Analysis of Cohort Studies

Jin

et al. 2022

Journal of Healthcare Engineering

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The phenomenon of low testosterone level is extremely common in male patients with chronic kidney diseases (CKDs). This meta-analysis aimed to evaluate whether the low circulating testosterone could independently predict adverse outcomes among male patients with chronic kidney diseases (CKDs). The data till May 2022 were systematically searched from Pubmed, Web of Science, and Embase from inception. Studies meeting the PICOS (population, intervention/exposure, control/comparison, outcomes, and study design) principles were included in this meta-analysis. Study-specific effect estimates were pooled using fixed-effects (I2 > 50%) or random-effects models (I2 < 50%). Ultimately, 9 cohort studies covering 5331 patients with CKDs were involved in this meta-analysis. The results suggested that per 1-standard deviation (SD) decrease in total testosterone independently increased the risk of all-cause mortality by 27% [hazard risk (HR) 1.27, 95% confidence interval (CI) 1.16–1.38], cardiovascular mortality by 100% (HR 2.00, 95% CI 1.39–2.86), cardiovascular events by 20% (HR 1.20, 95% CI 1.04–1.39), and infectious events by 41% (HR 1.41, 95% CI 1.08–1.84). Besides, with per 1-SD decrease in free testosterone, the risk of overall adverse events increased by 66% (HR 1.66, 95% CI 1.34–2.05). Stratified analyses indicated that the negative relationship of the total testosterone with all-cause death risk was independent of factors involving age, race, body mass index, diabetes, hypertension, C-reactive protein, creatinine, and sex hormone binding globulin. In conclusion, it was identified that low endogenous testosterone could serve as an independent predictor of adverse clinical events among male patients with CKDs.

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Section: Discussionmentioning

confidence: 99%

Low Testosterone Level and Risk of Adverse Clinical Events among Male Patients with Chronic Kidney Disease: A Systematic Review and Meta-Analysis of Cohort Studies

Jin

et al. 2022

Journal of Healthcare Engineering

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“…This is particularly important as the literature suggests that diabetes is associated with more severe forms of ED. [ 48 – 49 ]…”

Section: Discussionmentioning

confidence: 99%

The willingness of Saudi men with type 2 diabetes to discuss erectile dysfunction with their physicians and the factors that influence this

Almigbal

Schattner

2018

PLoS ONE

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ObjectivesThe study’s objectives were to find out the proportion of Saudi men with type 2 diabetes who have been asked by their physicians about erectile dysfunction (ED) in the last year, to determine the willingness of Saudi men with type 2 diabetes to discuss ED, and to explore the factors that may be related to their willingness to discuss ED with their physicians.MethodsThis study employed a cross-sectional survey design using a quantitative self-administered questionnaire among 309 Saudi men with type 2 diabetes. The study was conducted in hospital-based primary care clinics at King Khalid University Hospital, Riyadh, Saudi Arabia during the period from July to September 2015.ResultsThe mean age of the patients was 60.2 years with the mean duration of diabetes approximately 12.5 years. Few of the patients (9.7%) had been asked by their physicians about ED within the last year of attending the clinics although most patients (84.8%) were willing to discuss this issue. The presence of ED among the respondents was 89%. Two participants’ characteristics were associated with a willingness to discuss ED with the physicians. These characteristics were age above 60 (OR = 0.25, 95% CI: 0.11–0.55), and having severe ED (OR = 0.26, 95% CI: 0.08–0.85). The respondents’ main barriers to discussing ED with their physicians were embarrassing the doctor, ED is a personal issue, too old or too sick to address ED issues now, no effective treatment available, and the doctor is too young to discuss ED with.ConclusionsMost patients who have type 2 diabetes are not asked about ED within the last year of attendance even though most are willing to discuss it with their physicians. Being older and suffering more severe ED will result in being less willing to discuss ED with their doctor. Further research is needed to explore the barriers which prevent physicians from discussing ED with their patients who have diabetes.

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Erectile dysfunction in patients with arterial hypertension. Cardiovascular risk and impact on their quality of life

Diosdado-Figueiredo¹,

Balboa‐Barreiro

Pértega-Díaz

et al. 2019

Medicina Clínica (English Edition)

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The patient's comorbidity burden correlates with the erectile dysfunction severity

Cited by 5 publications

References 35 publications

Low Testosterone Level and Risk of Adverse Clinical Events among Male Patients with Chronic Kidney Disease: A Systematic Review and Meta-Analysis of Cohort Studies

Low Testosterone Level and Risk of Adverse Clinical Events among Male Patients with Chronic Kidney Disease: A Systematic Review and Meta-Analysis of Cohort Studies

The willingness of Saudi men with type 2 diabetes to discuss erectile dysfunction with their physicians and the factors that influence this

Erectile dysfunction in patients with arterial hypertension. Cardiovascular risk and impact on their quality of life

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