The patient-reported wearing-off phenomenon with monoclonal antibody treatments for multiple sclerosis
Lindsey M Marian,
Kathleen A Harris,
Devon S Conway
Abstract:Background Many patients report a wearing-off phenomenon with monoclonal antibody treatment for multiple sclerosis in which perceived benefits wear off before the next dose is due. Objectives To determine prevalence of the wearing-off effect, symptoms experienced, impact on treatment satisfaction, and associated patient characteristics. Methods Patients receiving natalizumab, ocrelizumab, ofatumumab, or rituximab at a tertiary multiple sclerosis center were invited to take an online survey interrogating their … Show more
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