The pathways mediating affective defense and quiet biting attack behavior from the midbrain central gray of the cat: an autoradiographic study

Shaikh, Majid B.; Barrett, Jeannette A.; Siegel, Allan

doi:10.1016/0006-8993(87)91522-8

Cited by 108 publications

(35 citation statements)

References 40 publications

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“…Cholinergic drugs injected into the lateral hypothalamus elicited muricide in rats [23,26], whereas the electrical stimulation of this brain area induced quiet biting in cats, a predatory form of aggression in this species [1,6,24,36,37]. In our muricidal rats, strong and highly muricide-specific activation was seen in the lateral hypothalamus along its whole rostro-caudal extent, which supports the notion that this region is a primary center for predatory aggression.…”

Section: Comparisons With Earlier Findingssupporting

confidence: 83%

“…This brain area is organized in columns, which are implicated in behavioral control diferentially. In cats, the stimulation of ventral columns (lateral and ventrolateral PAG) induces predatory attacks, whereas dorsal columns (dorsomedial and dorsolateral PAG) are involved in defensive responses [1,6,[48][49][50]. Here we found that muricidal attacks were accompanied by a dominantly ventral activation of the PAG.…”

Section: Comparisons With Earlier Findingsmentioning

confidence: 50%

“…Moreover, the activation of the central amygdala and lateral hypothalamus correlated significantly with the share of abnormal, predatory-like attacks in this model [22]. As the very same brain regions were shown to control predatory attacks in cats [1,[4][5][6], we proposed that antisocial-like aggressiveness in rats has a 'predatory dimension' as it regards both behavior and brain function. Unfortunately, however, the brain mechanisms of predatory aggression are less well known in rats than in cats.…”

Section: Introductionmentioning

confidence: 62%

“…This behavior is associated with minimal arousal, and does not involve social communication. These two forms of aggression are controlled by distinct neural circuits as shown by feline stimulation studies [4][5][6]. Based on phenomenological and physiological similarities, these types of aggressive behavior were proposed to be analogous with particular forms of psychopathological human aggression [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

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Neural mechanisms of predatory aggression in rats—Implications for abnormal intraspecific aggression

Tulogdi

Biró

Barsvári

et al. 2015

Behavioural Brain Research

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Our recent studies showed that brain areas that are activated in a model of escalated aggression overlap with those that promote predatory aggression in cats. This finding raised the interesting possibility that the brain mechanisms that control certain types of abnormal aggression include those involved in predation. However, the mechanisms of predatory aggression are poorly known in rats, a species that is in many respects different from cats. To get more insights into such mechanisms, here we studied the brain activation patterns associated with spontaneous muricide in rats. Subjects not exposed to mice, and those which did not show muricide were used as controls. We found that muricide increased the activation of the central and basolateral amygdala, and lateral hypothalamus as compared to both controls; in addition, a ventral shift in periaqueductal gray activation was observed.Interestingly, these are the brain regions from where predatory aggression can be elicited, or enhanced by electrical stimulation in cats. The analysis of more than 10 other brain regions showed that brain areas that inhibited (or were neutral to) cat predatory aggression were not affected by muricide. Brain activation patterns partly overlapped with those seen earlier in the cockroach hunting model of rat predatory aggression, and were highly similar with those observed in the glucocorticoid dysfunction model of escalated aggression. These findings show that the brain mechanisms underlying predation are evolutionarily conservative, and indirectly support our earlier assumption regarding the involvement of predation-related brain mechanisms in certain forms of escalated social aggression in rats.

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Section: Comparisons With Earlier Findingssupporting

confidence: 83%

Section: Comparisons With Earlier Findingsmentioning

confidence: 50%

Section: Introductionmentioning

confidence: 62%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Neural mechanisms of predatory aggression in rats—Implications for abnormal intraspecific aggression

Tulogdi

Biró

Barsvári

et al. 2015

Behavioural Brain Research

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“…However, Cameron et al (7) have shown that none of the columns of the PAG send direct projections to the PVN. On the other hand, the l/dlPAG sends projections to the DMH (7,38,39), a region that has been implicated in diverse stress-induced effects, including activation of the hypothalamic-pituitary-adrenal axis. Stotz-Potter and colleagues have shown that microinjection of muscimol into the DMH nearly abolishes the increases in HR and MAP seen in this paradigm and also reduces the accompanying increases in plasma ACTH levels (46).…”

Section: Discussionmentioning

confidence: 99%

Microinjection of muscimol into the periaqueductal gray suppresses cardiovascular and neuroendocrine response to air jet stress in conscious rats

Menezes¹,

Zaretsky²,

Sarkar³

et al. 2008

American Journal of Physiology-Regulatory, Integrative and Comp

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Reduced prefrontal and increased subcortical brain functioning assessed using positron emission tomography in predatory and affective murderers

et al. 1998

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There appear to be no brain imaging studies investigating which brain mechanisms subserve affective, impulsive violence versus planned, predatory violence. It was hypothesized that affectively violent offenders would have lower prefrontal activity, higher subcortical activity, and reduced prefrontal/subcortical ratios relative to controls, while predatory violent offenders would show relatively normal brain functioning. Glucose metabolism was assessed using positron emission tomography in 41 comparisons, 15 predatory murderers, and nine affective murderers in left and right hemisphere prefrontal (medial and lateral) and subcortical (amygdala, midbrain, hippocampus, and thalamus) regions. Affective murderers relative to comparisons had lower left and right prefrontal functioning, higher right hemisphere subcortical functioning, and lower right hemisphere prefrontal/subcortical ratios. In contrast, predatory murderers had prefrontal functioning that was more equivalent to comparisons, while also having excessively high right subcortical activity. Results support the hypothesis that emotional, unplanned impulsive murderers are less able to regulate and control aggressive impulses generated from subcortical structures due to deficient prefrontal regulation. It is hypothesized that excessive subcortical activity predisposes to aggressive behaviour, but that while predatory murderers have sufficiently good prefrontal functioning to regulate these aggressive impulses, the affective murderers lack such prefrontal control over emotion regulation. © 1998 John Wiley & Sons, Ltd.

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The pathways mediating affective defense and quiet biting attack behavior from the midbrain central gray of the cat: an autoradiographic study

Cited by 108 publications

References 40 publications

Neural mechanisms of predatory aggression in rats—Implications for abnormal intraspecific aggression

Neural mechanisms of predatory aggression in rats—Implications for abnormal intraspecific aggression

Microinjection of muscimol into the periaqueductal gray suppresses cardiovascular and neuroendocrine response to air jet stress in conscious rats

Reduced prefrontal and increased subcortical brain functioning assessed using positron emission tomography in predatory and affective murderers

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