The pathophysiology of vasovagal syncope: Novel insights

Dijk, J. Gert van; Rossum, Ineke A. van; Thijs, Roland D.

doi:10.1016/j.autneu.2021.102899

Cited by 30 publications

(25 citation statements)

References 83 publications

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“…Van de verschillende vormen van syncope is vasovagale syncope de meest voorkomende vorm. De pathophysiologie van vasovagale syncope omvat zowel vasodepressieve als cardio-inhibitoire componenten (van Dijk et al, 2021). Deze mechanismes kunnen op zichzelf optreden, maar treden meestal allebei op.…”

Section: Wel Of Geen Pacemakerunclassified

Uitdiepen van de wegraking

Thijs

2022

Epilepsie

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Op 26 januari 2022 promoveerde Dirk Saal aan de Universiteit Leiden op het proefschrift Understanding syncope in the framework of transient loss of consciousness. Zijn klinisch georiënteerde werk plaatst de verschillende vormen van syncope in het bredere perspectief van de wegraking, ofwel transient loss of consciousness. De bijdragen variëren van classificatie tot pathofysiologie, met als doel een beter begrip van de patroonherkenning van verschillende vormen van wegrakingen te krijgen.

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Section: Wel Of Geen Pacemakerunclassified

Uitdiepen van de wegraking

Thijs

2022

Epilepsie

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“…One of the most commonly organic diseases related to emotional distress is neurally mediated syncope or vasovagal syncope. In addition to common triggers such as dehydration, heat exposure, sudden change in position, prolonged standing, and acute pain, emotional stressors also lead to on-off loss of consciousness 12 .…”

Section: Developmentmentioning

confidence: 99%

Diagnostic pitfalls in functional neurological disorders

Filho

Mutarelli

2022

Arq. Neuro-Psiquiatr.

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The diagnosis of functional neurological disorders is a major challenge in neurologist practice. Some clinical strategies can facilitate the recognition of functional disorders, but several pitfalls make their diagnosis difficult. Here we highlight the following points of attention during evaluation of patients with functional disorder: not all bizarre behavior is functional; not every event triggered by an emotional factor is a functional disorder; not every topographic incongruity is a functional disorder; patients may present functional and organic symptoms at the same time; psychiatric comorbid condition is not always evident in the history of a functional disorder; problematic communication at the time of diagnosis can compromise treatment and prognosis. In conclusion, we emphasize that special attention to these possible pitfalls facilitate the correct diagnosis and management of functional neurological disorders.

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“…A Fig. 1 Key treatments for vasovagal syncope [1,5] and their impact on the vasovagal cascade [7] famous example is the report by Ladislaus von Bortkiewicz (1868-1931) who applied the Poisson distribution to evaluate the number of Prussian cavalrymen killed by horse kicks [16]. The figures perfectly fitted the expected numbers, thus demonstrating randomness and ruling out external factors like training year or cavalry corps.…”

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confidence: 96%

“…Although VVS is often labelled as "simple faint", the full story turns out to be more complex. Even if we simplify VVS by focussing on hemodynamic patterns of those with tilt-induced and often nitroglycerine-provoked VVS, we face diverse responses particularly regarding the occurrence and strength of cardioinhibition [7].…”

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confidence: 99%

“…Supressing the vasovagal reflex should predominantly focus on counteracting the central hypovolemia. A gradual decline of stroke volume seems to be the very first sign that precedes the decrease in heart rate and total peripheral resistance in VVS induced by head-up tilt [7]. The challenge for drug interventions is that it should be of sufficient strength to prevent the sporadic autonomic storm without negatively impacting the autonomic control in between events, e.g.…”

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confidence: 99%

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