The Pathophysiology of Cholesteatoma

Semaan, Maroun T.; Megerian, Cliff A.

doi:10.1016/j.otc.2006.08.003

Cited by 136 publications

(140 citation statements)

References 41 publications

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“…CCOM has been found to occur when keratinized squamous epithelium invades the middle ear and destroys nearby tissues. CCOM may also be involved in the severity and maintenance of inflammation [8] .…”

Section: Discussionmentioning

confidence: 99%

Change in Detection Rate of Methicillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa and Their Antibiotic Sensitivities in Patients with Chronic Suppurative Otitis Media

Kim

Kim²,

Kim³

et al. 2015

Int Adv Otol

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OBJECTIVE:To investigate changes in Pseudomonas aeruginosa (PA) and methicillin-resistant Staphylococcus aureus (MRSA) and their antibiotic sensitivities over 13 years in patients diagnosed with chronic suppurative otitis media (CSOM). MATERIALS and METHODS:The current study reports on a retrospective analysis of the outcomes of 2256 outpatients who visited the Department of Otorhinolaryngology clinics of 3 tertiary medical centers and who were diagnosed with chronic otitis media (COM) or chronic cholesteatomatous otitis media (CCOM) from January 2001 to December 2013. Aural discharge was collected from each patient. Infectious bacteria were identified, and their antibiotic sensitivities were determined. RESULTS:The most frequent age range of patients diagnosed with CSOM was 41 to 50 years. In patients aged more than 30 years, CSOM was more frequent in females than in males, whereas in those aged less than 30 years, it was more frequent in males. Regardless of age, the isolated MRSA strains showed high sensitivity to vancomycin, teicoplanin, and trimethoprim/sulfamethoxazole, whereas the isolated PA strains showed high sensitivity to cefepime, amikacin, and ceftazidime. The isolation rate of MRSA in patients with CSOM slightly decreased over the 13-year study period; however, PA resistance to quinolones and aminoglycosides showed a tendency to increase. CONCLUSION:Bacteria isolated from patients with CSOM showed little change between 2001 and 2013, whereas their antibiotic resistance showed changes; in particular, increased PA resistance to quinolones was observed. Empirical antibiotic treatment can lead to bacterial resistance, and changes in antimicrobial agents commonly used to treat CSOM should be considered.

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Section: Discussionmentioning

confidence: 99%

Change in Detection Rate of Methicillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa and Their Antibiotic Sensitivities in Patients with Chronic Suppurative Otitis Media

Kim

Kim²,

Kim³

et al. 2015

Int Adv Otol

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“…1,2 If the cholesteatoma becomes large enough, it will displace and eventually destroy the ossicles and erode the wall of the middle ear cavity (typically the lateral wall and the scutum). In children, even a small cholesteatoma can cause ossicular chain erosions and, consequently, conductive hearing loss.…”

mentioning

confidence: 99%

The Diagnostic Accuracy of Non-Echo-Planar Diffusion-Weighted Imaging in the Detection of Residual and/or Recurrent Cholesteatoma of the Temporal Bone

Dremmen¹,

Hofman²,

Hof³

et al. 2011

AJNR Am J Neuroradiol

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“…It is mainly divided into congenital and acquired types [2]. Acquired cholesteatoma is classified into primary and secondary types.…”

Section: Discussionmentioning

confidence: 99%

“…Experimental models by Massuda et al [2,4] has shown that epithelial migration of keratinizing epithelium at the edges of the tympanic membrane perforation as a possible cause of cholesteatoma development. In the present cases patients had central perforation and cholesteatoma was not present in the middle ear and attic, but it was found in the mastoid bone.…”

Section: Discussionmentioning

confidence: 99%

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Mastoid Cholesteatoma: A Result of Metaplasia

Viswanatha

Sarojamma

Roopashree

2011

Indian J Otolaryngol Head Neck Surg

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Presence of cholesteatoma in the middle ear of the patients with chronic mucosal otitis media has been reported in the literature. But presence of cholesteatoma only in the mastoid, in the absence of cholesteatoma in the middle ear of a patient with chronic mucosal otitis media, is not reported in the literature. In this article three cases of mastoid cholesteatoma, in patients with a clinical picture of chronic mucosal otitis media is reported along with the literature review.

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The Pathophysiology of Cholesteatoma

Cited by 136 publications

References 41 publications

Change in Detection Rate of Methicillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa and Their Antibiotic Sensitivities in Patients with Chronic Suppurative Otitis Media

Change in Detection Rate of Methicillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa and Their Antibiotic Sensitivities in Patients with Chronic Suppurative Otitis Media

The Diagnostic Accuracy of Non-Echo-Planar Diffusion-Weighted Imaging in the Detection of Residual and/or Recurrent Cholesteatoma of the Temporal Bone

Mastoid Cholesteatoma: A Result of Metaplasia

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