2008
DOI: 10.1016/j.bodyim.2007.11.002
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The pathophysiology of body dysmorphic disorder

Abstract: Body dysmorphic disorder (BDD) is an often severe and disabling condition, affecting up to 2% of the population. Despite its prevalence and clinical significance, very little is known about the pathophysiology of BDD. However, clues to its possible neurobiological substrates and abnormalities in information processing are starting to emerge. This article reviews findings from genetic, brain lesion, neuroimaging, neuropsychological, and psychopharmacological studies that have allowed us to develop a tentative m… Show more

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Cited by 44 publications
(27 citation statements)
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References 74 publications
(94 reference statements)
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“…The pathogenesis stems from an imbalance in the hemispheric, limbic system and frontal-subcortical circuit processing [9]. This condition can only be treated by psychiatric means: either serotonin-specific reuptake inhibitors or cognitive-behavioural therapy [10].…”
Section: Discussionmentioning
confidence: 99%
“…The pathogenesis stems from an imbalance in the hemispheric, limbic system and frontal-subcortical circuit processing [9]. This condition can only be treated by psychiatric means: either serotonin-specific reuptake inhibitors or cognitive-behavioural therapy [10].…”
Section: Discussionmentioning
confidence: 99%
“…Olfactory reference syndrome has been described as a discrete syndrome or disorder across many cultures for more than a century. 19,35 In DSM-5, olfactory reference syndrome is now mentioned as an example of not otherwise specified on the OCRD section, but has not been given a separate diagnosis. The argument for classifying olfactory reference disorder in the OCRD section involves: a) their similarity in phenomenology in terms of preoccupation and repetitive behaviors; b) the fact that OCD is a common comorbid condition for people with olfactory reference disorder 36 ; c) the fact that patients are more likely to receive a trial of pharmacological and psychological treatment used for OCRD rather than for a delusional disorder; that d) although the diagnosis appears uncommon, like BDD, patients may be highly ashamed of their symptoms and present with more acceptable symptoms, such as depression, OCD, or social anxiety 7,8 (when a separate diagnosis is available, this raises awareness of the condition and the likelihood of asking specific questions about olfactory reference disorder); and that e) a separate diagnosis will encourage auditing and research into the condition and better clinical care for such patients.…”
Section: Olfactory Reference Disorder In Icd-10 and Dsmmentioning
confidence: 99%
“…Il existe des études des anomalies du traitement des perceptions et des émotions, ainsi que des troubles de la mémoire, des patients BDD (pour revue voir [91]). Leurs résultats suggè-rent des dysfonctions cérébrales dans les régions impliquées dans les fonctions étudiées.…”
Section: Neuropsychologieunclassified