The Pathophysiological Role of Renal Dopamine, Kallikrein Kinin and Prostaglandin Systems in Essential Hypertension

Ito, Osamu; Shimamoto, Kazuaki; Ura, Nobuyuki; Nakagawa, M.; Nishimiya, Takatoshi; Ando, Toshiaki; Yamaguchi, Y; Masuda, Akira; Ogata, Hitoko; Saito, Shintaro

doi:10.1007/978-3-0348-9299-5_26

Cited by 10 publications

(12 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are conflicting reports (3,4,6,(19)(20)(21)(22) on plasma and urinary DA concentrations in patients with essential hypertension. Some studies have demonstrated that plasma or urinary excreted DA is enhanced in patients with borderline or early stage of essential hypertension (19).…”

Section: Da and Essential Hypertensionmentioning

confidence: 99%

“…Therefore, the dopaminergic activity changes with different stages of hypertension. Other studies have revealed decreased dopaminergic activity from the early stages of hypertension, because of an inherited defect in renal DA production (21,22). There also are conflicting reports in which the plasma free DA concentration in patients with essential hypertension was lower (4) or higher (3, 6) than that of normotensive patients.…”

Section: Da and Essential Hypertensionmentioning

confidence: 99%

See 1 more Smart Citation

Diagnostic Significance of Dopamine Estimation Using Plasma and Urine in Patients with Adrenal and Renal Insufficiency, Renal Transplantation and Hypertension

Yoshimura¹,

Komori²,

Nishimura³

et al. 1995

Hypertens Res

View full text Add to dashboard Cite

Although free and conjugated dopamine (DA) constitute most of the plasma and urine catecholamine pool, the diagnostic significance of DA estimation for the evaluation of illness is not clear. We evaluated the clinical utility of DA estimation by measuring free and conjugated DA in patients with various illness. Patients with adrenal insufficiency did not show decreases in DA concentrations but did demonstrate reductions in free and conjugated plasma adrenaline (Ad). Patients with established stage of essential hypertension exhibited decreased plasma concentrations of free and conjugated DA, although they were hyperadrenergic. In patients with chronic renal insufficiency and failure, the free DA concentration in the urine decreased depending on the severity of renal impairment. Conversely, plasma concentrations of conjugated DA are higher in patients with chronic renal failure than in normal subjects. The high plasma concentrations of conjugated DA decreased dramatically following hemodialysis and renal transplantation. Urinary free DA excretion increased markedly following renal transplantation. In conclusion, the estimation of the free and conjugated DA in plasma and urine is clinically useful for the diagnosis of adrenal insufficiency, essential hypertension, and renal insufficiency and failure. It also can be used to monitor the effectiveness of hemodialysis and renal transplantation. (Hypertens Res 1995; 18 Suppl. I: S87-S92) Key Words: free dopamine, conjugated dopamine, adrenal insufficiency, essential hypertension, renal transplantationWe have developed methods to measure free and conjugated catecholamines in clinical samples as a routine laboratory exam using HPLC and have tried to estimate the clinical utility of free and conjugated dopamine (DA) as a diagnostic aid (1). Previous investigators (2-7) have reported trace amounts of free DA in the plasma in various illness, but the values of free DA were variable in each study. Some studies (2-4) have reported relatively low free DA concentrations in the plasma, near the detection limits of the assay, while other studies (5, 6) have found relatively high concentrations of free DA in the plasma. Similarly, the plasma concentrations of conjugated DA were variable (2-7). We have already reported the wide individual variations and circadian rhythm of free and conjugated DA concentrations in healthy volunteers (8).The total DA, including the free and conjugated forms constitutes the majority (approximately 60-70%) of total circulating catecholamines including DA, noradrenaline (NA) and adrenaline (Ad) (Fig. 1). The physiological and pathological roles of plasma free NA and Ad are well-known. Although large amounts of DA exist in the circulation, the pathophysiological roles of free and conjugated DA are not clear. Moreover, it has been reported that conjugated DA can be converted directly into free DA,. Therefore, it is important to measure the free and conjugated DA independently when evaluating the pathophysiological significance of DA in the plasma. Although...

show abstract

Section: Da and Essential Hypertensionmentioning

confidence: 99%

Section: Da and Essential Hypertensionmentioning

confidence: 99%

Diagnostic Significance of Dopamine Estimation Using Plasma and Urine in Patients with Adrenal and Renal Insufficiency, Renal Transplantation and Hypertension

Yoshimura¹,

Komori²,

Nishimura³

et al. 1995

Hypertens Res

View full text Add to dashboard Cite

show abstract

“…The renal kallikrein-kinin system is a renal depressor system, as are the renal dopamine system and prostaglandin system (13,14). The renal kallikrein-kinin system is believed to play an important role in renal sodium regulation, and suppression of this system has been reported in patients with essential hypertension (15,16) and in several animal models (17). On the other hand, renal dopamine has been shown to exert natriuretic and diuretic actions by inhibiting Na ,K -ATPase and Na /H exchanger in the renal proximal tubules (13).…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, renal dopamine has been shown to exert natriuretic and diuretic actions by inhibiting Na ,K -ATPase and Na /H exchanger in the renal proximal tubules (13). The renal dopamine system is also impaired in experimental hypertensive animals and essential hypertensives (16,18). Moreover, urinary dopamine (uDA) excretion levels and urinary tissue kallikrein activity are decreased in patients with essential hypertension, and the levels of both endogenous natriuretic substances are negatively correlated with blood pressure level (16).…”

Section: Introductionmentioning

confidence: 99%

The Role of Renal Natriuretic and Depressor Systems in Insulin-Resistant Hypertensive Rats

et al. 2004

View full text Add to dashboard Cite

Insulin resistance and impairment of the renal depressor system have been thought to be involved in the development of essential hypertension. However, the relationship between insulin resistance and this system is still unclear. To clarify this relationship, we investigated the role of the renal depressor system in a rat model of insulin-resistant hypertension. Sprague-Dawley rats were fed a standard diet (control) or a fruc- important factor in the etiology and pathophysiology of essential hypertension (4, 5) and that compensating hyperinsulinemia leads to high blood pressure by several factors, such as prompted sodium reabsorption (6), stimulation of the sympathetic nervous system or renin-angiotensin system (7,8), and proliferation of vascular smooth muscle cells (1). Insulin resistance has also been reported in several animal models of hypertension, including spontaneously hypertensive rats and fructose-fed rats (FFR) (9). FFR become insulin-resistant due to a change in muscle fiber composition (10), peripheral vasoconstriction (11), or an increase in tumor necrosis factor-α (TNF-α) in skeletal muscle (12), and

show abstract

“…Our previous study showed that the change in urinary kallikrein activity (U-Kal) in the exercise group was significantly greater than that of the non-exercise group at week 1 and week 2. 15 Iimura et al 16 found that urinary free DA output is especially low in low-renin essential hypertensives, and that this was due to reduced renal conversion of plasma DOPA (3,4-dihydroxyphenylalanine) to DA. [17][18][19] Since 70% of urinary DA exist as the inactivated conjugated form, 20 we investigated free DA excretion (U-f-DA) rather than U-t-DA and the mechanism of the increase of renal DA.…”

Section: Introductionmentioning

confidence: 99%

Mild exercise activates renal dopamine system in mild hypertensives

et al. 1998

View full text Add to dashboard Cite

Objective: The role of renal dopamine in the early depressor effect of exercise was evaluated in hypertensives. Methods: After a general clinical observation period of 4 weeks, 29 essential hypertensives were divided into two groups. The exercise group (n = 16) underwent blood lactate threshold exercise using a cycle ergometer for 60 min three times a week for 4 weeks. Results: In the non-exercise group (n = 13), blood pressure (BP) and humoral variables did not change significantly (from 150 ± 3/93 ± 2 to 145 ± 2/94 ± 1 mm Hg). In the exercise group (n = 16), resting BP was significantly reduced from 158 ± 2/92 ± 2 at week 0 to 145 ± 3/85 ± 3 mm Hg at week 4. The increase in urinary free dopamine excretion (from 248 ± 14 to 276 ± 24 ng/mg Cr) at week 4 was significantly higher than that in the non-exercise group (from 220 ± 31 to 196 ± 27 ng/mg Cr). In the exercise group, urinary kallikrein activity also increased sig-

show abstract

The Pathophysiological Role of Renal Dopamine, Kallikrein Kinin and Prostaglandin Systems in Essential Hypertension

Cited by 10 publications

References 7 publications

Diagnostic Significance of Dopamine Estimation Using Plasma and Urine in Patients with Adrenal and Renal Insufficiency, Renal Transplantation and Hypertension

Diagnostic Significance of Dopamine Estimation Using Plasma and Urine in Patients with Adrenal and Renal Insufficiency, Renal Transplantation and Hypertension

The Role of Renal Natriuretic and Depressor Systems in Insulin-Resistant Hypertensive Rats

Mild exercise activates renal dopamine system in mild hypertensives

Contact Info

Product

Resources

About