The pathophysiological mechanisms of COVID-19 and host immunity, with emphasis on the dysbiosis of the lung and gut microbiomes and pregnancy

Asai, Nobuhiro; Kato, Hideo; Mikamo, Hiroshige

doi:10.1016/j.resinv.2022.03.002

Cited by 2 publications

(1 citation statement)

References 43 publications

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“…Lungs were previously thought to be sterile organs normally absent of microbiome (Bassis et al, 2015 ; Dickson et al, 2015 ). However, the lung microbiome has been clearly shown to exist, and it appears that the gut microbiome plays an important role to keep homeostasis with the lung microbiome known as the gut‐lung axis (Asai et al, 2022 ; Noverr et al, 2004 ; Yagi et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

A steroid‐resistant cockroach allergen model is associated with lung and cecal microbiome changes

Asai

Ethridge

Fonseca

et al. 2023

Physiological Reports

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The pathogenesis of asthma has been partially linked to lung and gut microbiome. We utilized a steroid‐resistant chronic model of cockroach antigen‐induced (CRA) asthma with corticosteroid (fluticasone) treatment to examine lung and gut microbiome during disease. The pathophysiology assessment demonstrated that mucus and airway hyperresponsiveness were increased in the chronic CRA with no alteration in the fluticasone (Flut)‐treated group, demonstrating steroid resistance. Analysis of mRNA from lungs showed no decrease of MUC5AC or Gob5 in the Flut‐treated group. Furthermore, flow‐cytometry in lung tissue showed eosinophils and neutrophils were not significantly reduced in the Flut‐treated group compared to the chronic CRA group. When the microbiome profiles were assessed, data showed that only the Flut‐treated animals were significantly different in the gut microbiome. Finally, a functional analysis of cecal microbiome metabolites using PiCRUSt showed several biosynthetic pathways were significantly enriched in the Flut‐treated group, with tryptophan pathway verified by ELISA with increased kynurenine in homogenized cecum samples. While the implications of these data are unclear, they may suggest a significant impact of steroid treatment on future disease pathogenesis through microbiome and associated metabolite pathway changes.

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Section: Introductionmentioning

confidence: 99%

A steroid‐resistant cockroach allergen model is associated with lung and cecal microbiome changes

Asai

Ethridge

Fonseca

et al. 2023

Physiological Reports

Self Cite

View full text Add to dashboard Cite

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COPD Pathogenesis and Alterations in the Oral, Lung, and Gut Microbiomes

Asai,

Ohkuni,

Kato

et al. 2024

Microbiology Research

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Chronic obstructive pulmonary disease (COPD) is a respiratory and systemic disease affecting more than 300 million people globally every year, and it also becomes a substantial economic burden. COPD is commonly comorbid with various underlying diseases such as cancer, cardiovascular diseases, cerebrovascular diseases, diabetes mellitus, osteoporosis, etc. It has been shown that statins can improve a significant decline in pulmonary function among COPD patients due to their pleiomorphic effect. Some systematic reviews also reported that statins reduced the risk of COPD-related events such as cancer and cardiovascular events, eventually resulting in more favorable outcomes than for non-statin user COPD patients. However, the physiological mechanism is still elucidated. Recently, it has been reported that statins influence the gut microbial composition with increased relative abundance of Akkermansia muciniphila and Faecalibacterium prausnitzii and act with pleiomorphic effects such as anti-inflammatory and anti-cancer effects through modulating gut dysbiosis. We described this review to focus on whether statins can be a useful preventive option for COPD.

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The pathophysiological mechanisms of COVID-19 and host immunity, with emphasis on the dysbiosis of the lung and gut microbiomes and pregnancy

Cited by 2 publications

References 43 publications

A steroid‐resistant cockroach allergen model is associated with lung and cecal microbiome changes

A steroid‐resistant cockroach allergen model is associated with lung and cecal microbiome changes

COPD Pathogenesis and Alterations in the Oral, Lung, and Gut Microbiomes

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