The pathology, pathobiology and pathogenesis of schistosomiasis

Warren, Kenneth S.

doi:10.1038/273609a0

Cited by 94 publications

(65 citation statements)

References 33 publications

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“…The prevalence of pathological changes is not always associated with egg output or laboratory tests; it is possible that disease is present, but that Schistosoma mansoni eggs are not being excreted and remain trapped in fibrous lesions 12 . Previous studies on experimental animals have estimated that 50% of the eggs are retained in tissues, especially in the liver 33 .…”

Section: Discussionmentioning

confidence: 99%

Clinical and ultrasound findings before and after praziquantel treatment among Venezuelan schistosomiasis patients

Ruiz-Guevara

Noya

Valero

et al. 2007

Rev. Soc. Bras. Med. Trop.

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Section: Discussionmentioning

confidence: 99%

Clinical and ultrasound findings before and after praziquantel treatment among Venezuelan schistosomiasis patients

Ruiz-Guevara

Noya

Valero

et al. 2007

Rev. Soc. Bras. Med. Trop.

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“…Over time, morbidity may progress from subtle manifestations such as anemia, to more severe, debilitating, and irreversible conditions such as growth stunting, impaired cognitive development, increased susceptibility to co-infection, decreased quality of life, exercise intolerance, infertility, portal hypertension, and liver failure. [9][10][11][12][13][14][15] The key determinants of morbidity progression are repeated infection, intensity of infection, and duration of infection. 16 Currently, the WHO strategy for schistosomiasis control relies on mass-drug administration (MDA) of praziquantel, 17 which is effective in reducing disease-associated morbidity.…”

Section: Introductionmentioning

confidence: 99%

Schistosoma mansoni Morbidity among School-Aged Children: A SCORE Project in Kenya

Samuels

Matey²,

Mwinzi³

et al. 2012

The American Society of Tropical Medicine and Hygiene

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Abstract. Schistosomiasis control programs aim to reduce morbidity but are evaluated by infection prevalence and intensity reduction. We present baseline cross-sectional data from a nested cohort study comparing indicators of morbidity for measuring program impact. Eight hundred twenty-two schoolchildren 7-8 years of age from Nyanza Province, Kenya, contributed stool for diagnosis of Schistosoma mansoni and soil-transmitted helminths (STH) and blood smears for malaria, and were evaluated for anemia, quality of life, exercise tolerance, anthropometry, and ultrasound abnormalities. Schistosoma mansoni, STH, and malaria infection prevalence were 69%, 25%, and 8%, respectively. Only anemia and S. mansoni infection (adjusted odds ratio [aOR] = 1.70; confidence interval [CI] = 1.03-2.80), and hepatomegaly and heavy S. mansoni infection (aOR = 2.21; CI = 1.19-4.11) were associated. Though anemia and hepatomegaly appeared most useful at baseline, additional morbidity indicators may be sensitive longitudinal measures to evaluate schistosomiasis program health impact.

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“…After that, they pair up and shed eggs, increasing the chance of invasion into the CNS. Warren et al [29] have studied the schistosomiasis epidemiology, pathology and autopsy. They report that there are connections between egg burden and the number of worms in the host.…”

Section: Spinal Cord Schistosomiasis and The Pathway Of Vertebral Batmentioning

confidence: 99%

Research development of the pathogenesis pathways for neuroschistosomiasis

Wang

Chen

et al. 2010

Neurosci. Bull.

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Abstract:The infection of the central nervous system (CNS) by schistosome may or may not have clinical manifestations.When symptomatic, neuroschistosomiasis (NS) is one of the most severe presentations of schistosome infection. Among the NS symptoms, cerebral invasion is mostly caused by Schistosoma japonicum (S. japonicum), and the spinal cord symptoms are mainly caused by S. mansoni or S. haematobium. There are 2 main pathways by which schistosomes cause NS: egg embolism and worm migration, via either artery or vein system, especially the valveless perivertebral Batson's plexus. The adult worm migrates anomalously through the above pathways to the CNS where they lay eggs. Due to the differences in species of schistosomes and stages of infection, mechanisms vary greatly. The portal hypertension with hepatosplenic schistosomiasis also plays an important role in the pathogenesis. Here the pathways through which NS occurs in the CNS were reviewed.

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The pathology, pathobiology and pathogenesis of schistosomiasis

Cited by 94 publications

References 33 publications

Clinical and ultrasound findings before and after praziquantel treatment among Venezuelan schistosomiasis patients

Clinical and ultrasound findings before and after praziquantel treatment among Venezuelan schistosomiasis patients

Schistosoma mansoni Morbidity among School-Aged Children: A SCORE Project in Kenya

Research development of the pathogenesis pathways for neuroschistosomiasis

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